“…At present, many studies show that abnormal expression of OPN is closely related with the occurrence and development of tumor such as liver cancer, breast cancer, colon cancer and some gynecological malignant tumor, whose possible mechanism is that OPN promotes the formation of neovascularization, chemotactic transfer and adhesion of cytokines as well as extracellular matrix degradation, and inhibits the cell apoptosis in different degree, especially tumor cells (Matušan et al, 2011;Huan et al, 2012;Tsai et al, 2012). At the same time, the research (Qiu et al, 2012) has confirmed that OPN is the important factor to induce the smooth migration of vascular muscle cell induced by angiotensin Ⅱ.…”