Osteopontin expression correlates with nuclear factor-κB activation and apoptosis downregulation in clear cell renal cell carcinoma

microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion

“…70% of renal tumors contain activated NFκB [97]. Furthermore, NFκB has been shown to correlate with renal tumor grade and metastasis [98].…”

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN

“…Previous study demonstrates that nuclear factor-kappaB (NF-kB) regulates OPN transcription in endotoxin-stimulated murine macrophages [10]. OPN expression correlates with NF-kB activation in clear cell renal cell carcinoma [11]. Therefore, we hypothesized that NF-kB-OPN pathway may be involved in mastitis.…”

Expression of Osteopontin in Non-small Cell Lung Cancer and Correlative Relation with Microvascular Density

“…At present, many studies show that abnormal expression of OPN is closely related with the occurrence and development of tumor such as liver cancer, breast cancer, colon cancer and some gynecological malignant tumor, whose possible mechanism is that OPN promotes the formation of neovascularization, chemotactic transfer and adhesion of cytokines as well as extracellular matrix degradation, and inhibits the cell apoptosis in different degree, especially tumor cells (Matušan et al, 2011;Huan et al, 2012;Tsai et al, 2012). At the same time, the research (Qiu et al, 2012) has confirmed that OPN is the important factor to induce the smooth migration of vascular muscle cell induced by angiotensin Ⅱ.…”