Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma

Abstract

The aim of this study is to explore the expression of osteopontin (OPN) and its relationship with prognostic factors and survival in diffuse large B cell lymphoma (DLBCL). A tissue microarray was performed for immunohistochemical evaluation. Contingency tables were analyzed for trends; chi-square test was used to determine differences between groups. Univariate and multivariate Cox proportional hazards-regression analyses were performed to evaluate the impact of prognostic factors on survival. Expression of OPN was observed in 28%. It was different in non-germinal center DLBCL (P=0.04). The mean overall survival (OS) was lower in patients with positive OPN expression (19.762; CI 95% 14.269-25.255) it was not significant (P=0.123). It is not possible to establish a clear relationship between the expression by immunohistochemistry of osteopontin and a poor prognosis but it would be important to complement the analysis with other techniques as PCR or NGS that allow us to assess the influence of the isoforms and post-translational modifications of OPN on the biological behavior of DLBCL. Our findings indicate that OPN expression could be associated with a more aggressive variant of lymphoma: non-germinal center DLBCL.

Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers?

“…Our study demonstrates, for the first time, that abnormally high levels of SPP1 are present in S-EVs circulating in the blood of pediatric ALCL patients, with higher levels in two patients that subsequently relapsed ( Figure S3g ). In a recent study, increased SPP1 expression was detected in diffuse large B-cell lymphoma by tissue microarray analysis, particularly in patients with reduced overall survival [ 37 ]. Similar to our findings in pediatric ALCL patients, circulating SPP1 was observed to be significantly higher in adult non-Hodgkin lymphoma patients compared to HDs [ 38 ].…”

Salivary Osteopontin as a Potential Biomarker for Oral Mucositis

“…Overexpression of OPN during aberrant hemopoiesis is one of the most common features of several hematologic malignancies, presumably as a consequence of the suppression of normal residual HSC proliferation [ 13 , 31 , 32 , 33 ]. Recent studies have described that serum OPN levels were increased in patients with MM and this correlated with disease progression and bone destruction [ 34 , 35 ]. Flamant et al observed that OPN expression had increased rapidly during progression of chronic myeloid leukaemia (CML), while remarkably declined in remission [ 36 ].…”

Immunoregulatory Roles of Osteopontin in Diseases

“…It is a prognostic marker in AML, as high OPN mRNA expression levels suggest reduced event-free survival and overall survival [ 68 ]. The prognosis of diffuse large B cell lymphoma (DLBCL), a type of non-Hodgkin lymphoma, is related to OPN expression which is found to be associated with non-germinal center DLBCL, a more aggressive type of lymphoma [ 69 ].…”