Osteopontin: another piece in the systemic lupus erythematosus immunopathology puzzle

Martín-Márquez, Beatriz-Teresita; Sandoval-García, Flavio; Corona-Meraz, Fernanda-Isadora; Petri, Marcelo-Heron; Gutiérrez-Mercado, Yanet-Karina; Mercado, Mónica Vázquez-Del

doi:10.55563/clinexprheumatol/x2g7rp

Cited by 7 publications

(7 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the prediction of clinical outcomes in other conditions, OPN has previously been evaluated in SLE [ 9 ]. Rullo et al reported that increased circulating OPN levels preceded increased cumulative disease activity and global organ damage in patients with SLE, especially in pediatric SLE [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is involved in both cell–cell and cell–matrix interactions crucial in the inflammatory response and can act as a soluble cytokine in inflamed tissues and circulation [ 8 ]. OPN is widely distributed in normal adult human tissues, being abundantly expressed by osteoclasts and osteoblasts in bone matrix and present in kidneys, epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lungs, breast, salivary glands, sweat glands, inner ear, brain, decidua, placenta, arteries, human blood, and body fluids such as urine and milk [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

et al. 2023

View full text Add to dashboard Cite

Several scoring systems for clinical prediction of the severity of acute pancreatitis (AP) have been proposed. Yet, there is still a need for an easy-to-measure biomarker. Osteopontin (OPN) may be released to the circulation early during tissue injury, but the significance of OPN in AP has not yet been established. We aimed to evaluate plasma levels of OPN in relation to the severity of AP. In 39 individuals with confirmed AP, plasma was collected on the day of admission and consecutively for three days thereafter. Sex- and age-matched healthy blood donors (n = 39) served as controls. Plasma OPN was measured by a commercial enzyme-linked immunosorbent assay. At admission, patients with AP displayed higher OPN, 156.4 ng/mL (IQR 111.8–196.2) compared to controls, 37.4 ng/mL (IQR 11.7–65.7) (p < 0.0001). However, OPN levels on admission could not discriminate between mild and moderate-to-severe disease (132.6 ng/mL vs. 163.4 ng/mL). Nevertheless, the changes in OPN within 24 h of admission and Day 2/3 were higher among patients with moderate/severe AP (33.7%) compared to mild AP (−8.1%) (p = 0.01). This indicates that OPN is a relevant biomarker reflecting tissue injury in AP. The increase in OPN over time suggests that serial OPN measurements could contribute to the early detection of at-risk patients. Prospective studies assessing OPN in relation to outcome in AP are warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…OPN is a biomarker and indicates bad prognosis of SLE. Circulating OPN levels are related to anti-dsDNA autoantibodies, subclinical atherosclerosis associated with SLE, and lupus nephritis [ 103 , 104 , 105 ].…”

Section: Immunoregulatory Roles Of Opn In Diseasesmentioning

confidence: 99%

Immunoregulatory Roles of Osteopontin in Diseases

Wang,

Niu

2024

Nutrients

View full text Add to dashboard Cite

Osteopontin (OPN) is a multifunctional protein that plays a pivotal role in the immune system. It is involved in various biological processes, including cell adhesion, migration and survival. The study of the immunomodulatory effects of OPN is of paramount importance due to its potential therapeutic applications. A comprehensive understanding of how OPN regulates the immune response could pave the way for the development of novel treatments for a multitude of diseases, including autoimmune disorders, infectious diseases and cancer. Therefore, in the following paper, we provide a systematic overview of OPN and its immunoregulatory roles in various diseases, laying the foundation for the development of OPN-based therapies in the future.

show abstract

“…OPN is expressed in high concentrations in inflammatory and autoimmune diseases such as Crohn’s disease, cirrhosis, obesity, atherosclerosis, cancer, systemic lupus erythematosus (SLE), multiple sclerosis (MS), atherosclerosis, RA, and OA, among others [ 37 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

“…In autoimmune diseases, OPN exerts its harmful activity by promoting the secretion of IFN-γ and interleukin 17 (IL-17) in T cells and IL-6 in monocytes and supporting T follicular helper (TF H ) differentiation [ 64 ]. In SLE, OPN enhances the inflammatory process-activating T cells, NK, and macrophages driving T H 1 cell differentiation, and it could be involved in the propagation and differentiation of B cells and autoantibodies production [ 53 ]. Regarding MS, OPN promotes the activation and survival of autoreactive T cells and is associated with relapses [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology

et al. 2023

Self Cite

View full text Add to dashboard Cite

Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and pathological mechanisms that nowadays has gained relevance due to its role in the immune system response to chronic degenerative diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). OPN is an extracellular matrix (ECM) glycoprotein that plays a critical role in bone remodeling. Therefore, it is an effector molecule that promotes joint and cartilage destruction observed in clinical studies, in vitro assays, and animal models of RA and OA. Since OPN undergoes multiple modifications, including posttranslational changes, proteolytic cleavage, and binding to a wide range of receptors, the mechanisms by which it produces its effects, in some cases, remain unclear. Although there is strong evidence that OPN contributes significantly to the immunopathology of RA and OA when considering it as a common denominator molecule, some experimental trial results argue for its protective role in rheumatic diseases. Elucidating in detail OPN involvement in bone and cartilage degeneration is of interest to the field of rheumatology. This review aims to provide evidence of the OPN’s multifaceted role in promoting joint and cartilage destruction and propose it as a common denominator of AR and OA immunopathology.

show abstract

Osteopontin: another piece in the systemic lupus erythematosus immunopathology puzzle

Cited by 7 publications

References 59 publications

Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

Plasma Osteopontin Reflects Tissue Damage in Acute Pancreatitis

Immunoregulatory Roles of Osteopontin in Diseases

Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology

Contact Info

Product

Resources

About