Osteopontin and symmetric dimethylarginine plasma levels in solitary functioning kidney in children

Abstract

Aim: The present study aimed to examine whether plasma osteopontin (pOPN) and symmetric dimethylarginine (pSDMA) are useful biomarkers of renal dysfunction in children with solitary functioning kidney (SFK). Methods: We measured circulating pOPN and pSDMA in 51 patients with SFK and no other urinary defects. Patients were subdivided into two groups: primary SFK (pSFK) – unilateral renal agenesis (URA), and secondary SFK (sSFK) – unilateral nephrectomy. The control group (C) contained 21 healthy children, with mean age 9.92 ± 4.85 years. Immunoenzymatic ELISA commercial kits were used to measure pOPN and pSDMA concentrations. Results: Plasma osteopontin and pSDMA levels in children with SFK were higher than those in healthy participants (p < 0.05). There was no difference in pOPN and pSDMA concentrations between patients with pSFK and those with sSFK (p > 0.05). Receiver operator characteristic analyses performed to define the diagnostic efficiency of serum creatinine, pOPN and pSDMA in identifying children with Ccr < 90 mL/min/1.73 m2 among all examined children revealed no differences between all three AUCs (p > 0.05). Conclusion: Increased pOPN and pSDMA levels were observed in children with SFK. Both pOPN and pSDMA correlated with eGFR; however, the sensitivity and specificity of those markers were not better than those of creatinine.

Arginine dimethylation products in pediatric patients with chronic kidney disease

“…Similarly, Taranta-Janusz and colleagues [45] , reported increased plasma osteopontin and SDMA levels in children with solitary functioning kidney and both plasma osteopontin and SDMA levels were correlated with eGFR. Recently, Protas et al.…”

Precision of Estimating Equations for GFR in Children with a Solitary Functioning Kidney

“…After an initiative by the International Federation of Clinical Chemistry, a uniform calibrator for cystatin C has been developed, which will probably improve the implementation of cystatin C as a marker for pediatric CKD (38). In this light, it would also be interesting to compare cystatin C with novel markers for CKD in patients with an SFK, such as fibroblast growth factor 23, osteopontin, and symmetric dimethylarginine (39,40).…”

Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney

“… Brooks et al (2008) observed reduced plasma arginine and elevated ADMA and SDMA in pediatric/adolescent CKD (stage 2–3) patients, with SDMA demonstrated to be a strong indicator of reduced GFR. Importantly, in a small cohort of 51 children with a SFK at a mean age of ∼10 years, plasma SDMA was significantly elevated and negatively correlated with GFR, suggesting that plasma SDMA may serve as a marker of endothelial dysfunction in children with a SFK ( Taranta-Janusz et al, 2012 ).…”