Osteopontin and Ki-67 expression in World Health Organization graded canine meningioma

Janssen, Janina; Oevermann, Anna; Walter, Ingrid; Tichy, Alexander; Kummer, Stefan; Gradner, Gabriele

doi:10.1016/j.jcpa.2022.12.011

Cited by 2 publications

(4 citation statements)

References 49 publications

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“…25 OPN immunolabeling was also correlated negatively with tumor infiltration, suggesting that it could be used as a predictor of tumor recurrence. 25 However, these findings need to be validated and no clear associations between canine and feline meningioma type or grade and different IHC profiles have been found to date. 1 Additional immunohistochemical studies of canine meningioma have assessed the immunolabeling profile of cyclooxygenase-2 (COX-2).…”

Section: Meningiomamentioning

confidence: 96%

“…24 Similarly, cytoplasmic osteopontin (OPN) immunolabeling has been reported in canine meningioma independent of type and grade. 25 OPN immunolabeling was also correlated negatively with tumor infiltration, suggesting that it could be used as a predictor of tumor recurrence. 25 However, these findings need to be validated and no clear associations between canine and feline meningioma type or grade and different IHC profiles have been found to date.…”

Section: Primary Cns Neoplasmsmentioning

confidence: 96%

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Diagnostic immunohistochemistry of primary and secondary central nervous system neoplasms of dogs and cats

Rissi,

Miller,

Demeter

et al. 2024

J VET Diagn Invest

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The diagnosis of primary and secondary CNS neoplasms of dogs and cats relies on histologic examination of autopsy or biopsy samples. In addition, many neoplasms must be further characterized by immunohistochemistry (IHC) for a more refined diagnosis in specific cases. Given the many investigations assessing the diagnostic and prognostic IHC profile of CNS neoplasms in the veterinary literature, it may be difficult for the diagnostic pathologist or pathology trainee to narrow the list of reliable diagnostic IHCs when facing a challenging case. Here we compile a comprehensive list of the most diagnostically relevant immunomarkers that should be utilized for the diagnostic support or confirmation of the most common primary and secondary CNS neoplasms of dogs and cats.

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Section: Meningiomamentioning

confidence: 96%

Section: Primary Cns Neoplasmsmentioning

confidence: 96%

Diagnostic immunohistochemistry of primary and secondary central nervous system neoplasms of dogs and cats

Rissi,

Miller,

Demeter

et al. 2024

J VET Diagn Invest

View full text Add to dashboard Cite

show abstract

“…Matiasek et al (2009) did not find the same prediction; however, this was a retrospective study performed with a small sample size [143]. Janssen et al (2023) studied the expression of KI-67 in 68 canine meningiomas to correlate KI-67 expression with the WHO grading of meningioma [148]. Many samples positive for KI-67 were classified as WHO grade I and the authors hypothesized a possible role of KI-67 in meningioma development, in particular during the early stage of these tumors [148].…”

Section: Diagnosismentioning

confidence: 97%

“…Janssen et al (2023) studied the expression of KI-67 in 68 canine meningiomas to correlate KI-67 expression with the WHO grading of meningioma [148]. Many samples positive for KI-67 were classified as WHO grade I and the authors hypothesized a possible role of KI-67 in meningioma development, in particular during the early stage of these tumors [148]. Saito et al ( 2021) did not correlate Ki-67 with specific subtypes of feline meningiomas [134].…”

Section: Diagnosismentioning

confidence: 99%

Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas

Tomanelli,

Florio,

Vargas

et al. 2023

Life

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Intracranial primary tumors (IPTs) are aggressive forms of malignancies that cause high mortality in both humans and domestic animals. Meningiomas are frequent adult IPTs in humans, dogs, and cats, and both benign and malignant forms cause a decrease in life quality and survival. Surgery is the primary therapeutic approach to treat meningiomas, but, in many cases, it is not resolutive. The chemotherapy and targeted therapy used to treat meningiomas also display low efficacy and many side effects. Therefore, it is essential to find novel pharmacological approaches to increase the spectrum of therapeutic options for meningiomas. This review analyzes the similarities between human and domestic animal (dogs and cats) meningiomas by evaluating the molecular and histological characteristics, diagnosis criteria, and treatment options and highlighting possible research areas to identify novel targets and pharmacological approaches, which are useful for the diagnosis and therapy of this neoplasia to be used in human and veterinary medicine.

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Osteopontin and Ki-67 expression in World Health Organization graded canine meningioma

Cited by 2 publications

References 49 publications

Diagnostic immunohistochemistry of primary and secondary central nervous system neoplasms of dogs and cats

Diagnostic immunohistochemistry of primary and secondary central nervous system neoplasms of dogs and cats

Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas

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