Osteopontin: a potentially important therapeutic target in cancer

Ahmed, Mansoor; Behera, Reeti; Chakraborty, Goutam; Jain, Shalini; Kumar, Vinit; Sharma, Priyanka; Bulbule, Anuradha; Kale, Smita; Kumar, Santosh; Mishra, Rajneesh Kumar; Raja, Remya; Saraswati, Supriya; Kaur, Rajinder; Soundararajan, Gowrishankar; Kumar, Dhiraj; Thorat, Dhanashri; Sanyal, Megha; Ramdasi, Anuja; Ghosh, Pompom; Kundu, Gopal C.

doi:10.1517/14728222.2011.594438

Cited by 65 publications

(56 citation statements)

References 90 publications

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“…Our data indicates that CD133 + subpopulation exhibits higher percentage of SP phenotypes which probably associated with chemoresistance against DTIC, Dox, Dabrafenib and Trametinib [7]. Osteopontin, a cytokine has multiple role in tumor progression and metastasis [10,11]. The study by Pietras et al have showed that osteopontin (OPN)-CD44 signaling axis in glioma niche enhances CSCs traits and promotes aggressive tumor growth [12].…”

Section: Commentarymentioning

confidence: 70%

Notch1-MAPK Signaling Axis is Essential in CD133+ Melanoma Initiating Cells

Kumar¹,

Pandey²,

Kundu³

2017

J Cell Signal

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Section: Commentarymentioning

confidence: 70%

Notch1-MAPK Signaling Axis is Essential in CD133+ Melanoma Initiating Cells

Kumar¹,

Pandey²,

Kundu³

2017

J Cell Signal

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“…According to previous studies, OPN is overexpressed in various cancers [20] such as colon [21], breast [22], gastrointestinal, and liver cancers [23]. In particular, OPN is also overexpressed in NSCLC [3].…”

Section: Discussionmentioning

confidence: 93%

Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA

Cho

Hong

Singh

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…OPN [9, 37] and CD44 [38, 39] are closely involved in metastasis process. Western blotting revealed that EEOS downregulated the expression of OPN and CD44 in NCI-H460 cells (Figure 4A) and also suppressed the expression of CD44 in OPN treated NCI-H460 cells (Figure 4B).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells

Kwak

Sohn

Kim

et al. 2014

BMC Complement Altern Med

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BackgroundOsteopontin (OPN) is one of important molecular targets in cancer progression, metastasis as a calcium-binding, extracellular-matrix-associated protein of the small integrin-binding ligand and, N-linked glycoprotein. In the present study, anti-metastatic mechanism of ethanol extracts of Ocimum sanctum (EEOS) was elucidated on OPN enhanced metastasis in NCI-H460 non- small cell lung cancer cells.MethodsCell viability was measured by MTT assay. Adhesion and invasion assays were carried out to see that EEOS inhibited cell adhesion and invasion in OPN treated and non-treated NCI-H 460 cells. RT-PCR was used to determine the mRNA levels of uPA, uPAR, and EGFR.ResultsEEOS significantly inhibited cell adhesion and invasion in OPN treated and non treated NCI-H460 cells, though EEOS did not show any toxicity up to 200 μg/ml. EEOS effectively attenuated the expression of OPN and CD44 and also OPN activated the expression of CD44 in NCI-H460 cells. In addition, EEOS effectively suppressed the expression of phosphatidylinositide 3-kinases (PI3K) and cyclooxygenase 2 (COX-2) and the phosphorylation of Akt at protein level in OPN treated NCI-H460 cells. Also, EEOS significantly attenuated the expression of urokinase plasminogen activator (uPA), its receptor (uPAR) and epidermal growth factor receptor (EGFR) at mRNA level and reduced vascular endothelial growth factor (VEGF) production and MMP-9 activity in OPN treated NCI-H460 cells. Furthermore, PI3K/Akt inhibitor LY294002 enhanced anti-metastatic potential of EEOS to attenuate the expression of uPA and MMP-9 in OPN treated NCI-H 460 cells.ConclusionOverall, our findings suggest that anti-metastatic mechanism of EEOS is mediated by inhibition of PI3K/Akt in OPN treated NCI-H460 non-small cell lung cancer cells.

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Osteopontin: a potentially important therapeutic target in cancer

Cited by 65 publications

References 90 publications

Notch1-MAPK Signaling Axis is Essential in CD133+ Melanoma Initiating Cells

Notch1-MAPK Signaling Axis is Essential in CD133+ Melanoma Initiating Cells

Suppression of tumor growth in lung cancer xenograft model mice by poly(sorbitol-co-PEI)-mediated delivery of osteopontin siRNA

Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells

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