Osteoplasty Using Calcium Hydroxylapatite Filler

Vagefi, M. Reza; McMullan, Tristan F. W.; McCann, John D.; Anderson, Richard L.

doi:10.1097/iop.0b013e3181719f8f

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…In 2007, Stupak et al described HA injection for the treatment of postrhinoplasty contour deficiences . In 2008, after intially experimenting with Radiesse for postenucleation orbital augmentation, Vagefi et al introduced the concept of injectable osteoplasty for small frontal bone defects . In their novel description, three patients were injected with Radiesse in conjunction with other eyelid procedures.…”

Section: Discussionmentioning

confidence: 99%

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A preliminary report of percutaneous craniofacial osteoplasty in a rat calvarium

et al. 2013

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Objectives/Hypothesis To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatability and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model. Study Design Randomized controlled animal model. Methods Fourteen adult Sprague Dawley rats were injected in the parietal skull with 0.2 ml of hydroxylapatite (10 animals) or 0.2 ml of a carrier gel control (4 animals), using a subperiosteal injection technique on the right and a subcutaneous injection technique on the left. At 1, 3, and 6 months, three rats (1 negative control, 2 variables) were sacrificed and the calvaria were harvested. At 12 months, the remaining five rats were sacrificed. After each harvest, the specimens were processed and then examined under both light and polarized microscopy for new bone growth at the injection sites. Results The inflammatory response was limited with both hydroxylapatite and carrier injections. Injectables were still present 12 months after the injection. New bone formation was only observed when the injection was located deep to a disrupted periosteum The odds of new bone formation was 48.949 times higher (95% confidence intervals CI [2.637, 3759.961]; P = 0.002) with subperiosteal hydroxylapatite injections compared to all other combinations of injection plane and injectable. Conclusions This preliminary report of subperiosteal hydroxylapatite (Radiesse) injection in a rat model has verified the biocompatibility of injectable hydroxylapatite at the bony interface and suggests the potential for new bone formation. Level of Evidence N/A. Laryngoscope, 124:1550–1553, 2014

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Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Not surprisingly, off label uses of Radiesse have arisen as well. [8][9][10] To our knowledge, no one to date has examined the histologic effects of Radiesse injection at the bony interface. We have now shown that Radiesse is biocompatible and long-lasting subperiosteally.…”

Section: Methods: Fourteen Adult Spraguementioning

confidence: 99%

A preliminary report of percutaneous craniofacial osteoplasty in a rat calvarium

et al. 2013

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“…The blood clot wraps nHA inside, which may speed up the extraction socket repair [8]. Holzapfel [9] and Vagefi [10] have confirmed that filling nHA in extraction sockets can effectively prevent the absorption of the alveolar ridge. Histochemical results showed obvious new bone formation and nHA helps occupy the space for the new bone.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Application between Different Proportional nHA / PLA in Alveolar Bone Preservation

Bai

Liu

Chen

et al. 2014

KEM

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Objective: To compare the effectiveness of different proportional nHA / PLA application in alveolar bone preservation. Methods: After extraction, apply extraction socket filling based on the alveolar bone defect model due to absorption in Beagle dog. Implant materials are divided into 3 different groups: nHA / PLAI, nHA / PLAII and the control group. Samples of the alveolar bone were collected at Week 4 and 8, respectively for the bone resorption assessment, bone density measurement, and histological examination. Results: After nHA / PLA implantation, the alveolar bone preservation was significantly improved. There was no difference in the alveolar bone preservation between the nHA / PLAI and nHA / PLAII groups. However, the sample which are 8w from group I, have higher bone density and have complete absorption in their dental material nest .Therefore group I is better than group II. Conclusions: The results can provide a reliable basis for the application of alveolar bone preservation in basic research and selection of clinical materials.

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