Osteopenia of prematurity: a national survey and review of practice

Harrison, Catherine M; Johnson, Katherine A.; McKechnie, E

doi:10.1111/j.1651-2227.2007.00721.x

Cited by 115 publications

(137 citation statements)

References 42 publications

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“…This is in contrast to other studies, in which it is considered as lower values around 500 IU/L 1,12,13,23 .…”

Section: Discussioncontrasting

confidence: 50%

“…The analytical figures from which there is osteopenia are not well defined at the moment in data already published, although the alkaline phosphatase is the most accepted biomarker for its diagnosis 1,13 . Along with this determination, we had not seen a relationship between the numbers of 25 (OH) vitamin D and PTH and the osteopenia development in our study, but we had seen it with those of alkaline phosphatase.…”

Section: Discussionmentioning

confidence: 99%

“…Any parameter can be considered isolated as MBD marker, although the most commonly used is the serum alkaline phosphatase. The figures that determine the diagnosis are not clearly defined in the literature, but in some series it is accepted that above 500 IU/L as a high sensitivity and specificity, and in others, above 700 IU/L 1,12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…This condition may be favored by several nutritional and biomechanical factors, such as prolonged nutrient deficiency, immobilization and parenteral nutrition, as well as the intake of antagonistic medications with bone metabolism [1][2][3] . Although in the past the incidence of this pathology was similar or even greater than the current one, the progressive reduction of mortality in the last years and the growing clinical experience, allowed for a systematic search of osteopenia and MBD (affecting the premature ones) as a usual clinical practice in centers with experience in neonatology.…”

Section: Introductionmentioning

confidence: 99%

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Factores de riesgo y marcadores bioquímicos de la enfermedad metabólica ósea del recién nacido prematuro

Ramón

Espuelas

Calmarza

et al. 2017

Rev. chil. pediatr.

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Background: Metabolic bone disease (MBD) of prematurity is a complication of multifactorial aetiology, which has been increasing, due to progressive decrease in mortality of preterm newborns. The aim of the study was to analyze risk factors of severe MBD and its analytical markers. Patients and Method: Retrospective study involving preterm infants less than 32 weeks gestational age and/or weight less tan 1,500 g born between january 2012 and december 2014. Comparison was made according to the presence of severe MBD. Results: 139 patients were recruited. Mean value of 25(OH)D3 was 70.68 ± 25.20 nmol/L, being higher in patients born in spring-summer than in autumn-winter (80.94 ± 25.33 vs 61.13 ± 21.07; p = 0.000). Levels of 25(OH)D3 were similar in patients with severe MBD compared with the rest of patients (65.61 ± 26.49 vs 72.07 ± 24.89, P = 0.283). Higher levels of alkaline phosphatase (AP, IU/L ) (1314.19 ± 506.67 vs 476.56 ± 188.85; p = 0.000) were found in these patients. Cutoff point of AP 796.5 IU/L (S 95.2%, specificity 92.4%) was calculated by ROC curve. The risk factors most associated to severe EMO were restricted fetal growth, birth weight, duration of ventilation therapy and parenteral nutrition. Conclusions: AP levels were the best marker of severe MBD development. EMO risk increases with the number of risk factors and lower levels of 25(OH) D3. Levels of 25(OH)D3 higher than 70nmol/L appear to protect from the development of severe MBD, even in patients with multiple risk factors.

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“…This is in contrast to other studies, in which it is considered as lower values around 500 IU/L 1,12,13,23 .…”

Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factores de riesgo y marcadores bioquímicos de la enfermedad metabólica ósea del recién nacido prematuro

Ramón

Espuelas

Calmarza

et al. 2017

Rev. chil. pediatr.

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show abstract

“…The most common risk factors are inadequate supply of calcium and phosphorus, immobility, parenteral nutrition, diuretic or steroid therapy. 4 Treatment is aimed at beginning enteral feedings as soon as possible to allow efficient absorption of phosphate, and adequate doses of Vitamin D. …”

Section: Denouement and Discussionmentioning

confidence: 99%