Osteopenia in patients infected by the human immunodeficiency virus. A case control study

Loiseau-Pérès, Sylvie; Delaunay, Caroline; Poupon, S.; Lespessailles, Éric; Ballouche, Nourdine; Arsac, P.; Benhamou, Claude-Laurent

doi:10.1016/s1297-319x(02)00433-5

Cited by 41 publications

(28 citation statements)

References 7 publications

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“…Hypogonadism has been documented in up to 60% of HIV-positive men and may also be prevalent in premenopausal, HIV-positive women [14,15]. Increased levels of proinflammatory cytokines associated with HIV infection, including IL-1, IL-6, and TNF, may also contribute directly to accelerated bone loss [16].…”

Section: (See the Editorial Commentary By Yin And Glesby On Pages 102mentioning

confidence: 99%

“…Several studies have reported an increased prevalence of reduced bone mineral density (BMD) among persons with HIV infection [16][17][18][19][20][21][22][23][24]. Although some early studies found an association between reduced BMD and protease inhibitor therapy [20,23,25,26], other studies have not confirmed this association [19,21,22,27,28] or have suggested that other antiretrovirals may be important etiologic agents [29].…”

Section: (See the Editorial Commentary By Yin And Glesby On Pages 102mentioning

confidence: 99%

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HIV Infection and Bone Mineral Density in Middle-Aged Women

Arnsten

Freeman

Howard

et al. 2006

Clinical Infectious Diseases

125

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Background. Osteopenia is prevalent in persons with human immunodeficiency virus (HIV) infection and is part of a normal sequence of aging in women. Most studies of bone mineral density (BMD) and HIV infection have focused on men or have lacked a comparison group of individuals without HIV infection with similar behavioral risk factors.Methods. We analyzed BMD in 495 middle-aged women (defined as women у40 years of age); 263 women had HIV infection, and 232 women were HIV-negative with behavioral risk factors similar to those of the HIVpositive group.Results. The median age of the women in the study was 44 years, 54% were black, and 92% had used illicit drugs. Femoral neck BMD and lumbar spine BMD were reduced in women with HIV infection, compared with women without HIV infection (femoral neck BMD, g/cm 2 vs. g/cm 2 ; ; lumbar 1.01 ‫ע‬ 0.13 1.05 ‫ע‬ 0.13 P p .001 spine BMD, g/cm 2 vs. g/cm

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Section: (See the Editorial Commentary By Yin And Glesby On Pages 102mentioning

confidence: 99%

Section: (See the Editorial Commentary By Yin And Glesby On Pages 102mentioning

confidence: 99%

HIV Infection and Bone Mineral Density in Middle-Aged Women

Arnsten

Freeman

Howard

et al. 2006

Clinical Infectious Diseases

125

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“…These include physical inactivity [3], decreased intake of calcium and vitamin D [4], cigarette smoking [5][6][7], alcohol use, depression [8][9][10], opiate use [11] and low testosterone levels [12,13]. Increased levels of pro-inflammatory cytokines associated with HIV infection, including interleukin-1, interleukin-6 and tumor necrosis factor, may also contribute directly to accelerated bone loss [14].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported an increased prevalence of reduced bone mineral density (BMD) among HIVinfected persons [14][15][16][17][18][19][20][21]. Although an association between reduced BMD and protease inhibitor therapy has been suggested [20], a number of studies have not confirmed this association [17,19,20,[22][23][24][25][26] or have suggested that other antiretrovirals such as tenofovir may be important etiologic agents [27].…”

Section: Introductionmentioning

confidence: 99%

Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection

Arnsten

Freeman

Howard³

et al. 2007

Aids

232

172

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“…Most studies in patients with human immunodeficiency virus (HIV) infection have reported a decreased BMD [1][2][3][4][5][6][7][8][9][10][11][12]. Only two studies did not report a decreased BMD [13,14].…”

Section: Drugs Against Hivmentioning

confidence: 99%

Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology

Vestergaard

2007

Clinic Rev Bone Miner Metab

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Drugs may affect bone turnover and density in many ways. However, the disease for which the drugs are administered may also contribute to bone loss. Infection with human immunodeficiency virus leads to a loss of bone mineral, while treatment with highly active antiretroviral therapy does not seem to contribute to further bone loss. Type 1 diabetes is associated with a decrease in bone mineral, while type 2 diabetes is associated with an increase. The new class of thiazolidinediones (glitazones) has been associated with an increased loss of bone mineral. In breast cancer treatment, tamoxifen is associated with an increased bone mineral, while the newer class of aromatase inhibitors through a decrease in serum oestradiol are associated with an increased loss of bone mineral. Strong analgesics (opioids) may decrease bone mineral density through inhibition of gonadotrophins while weak analgesics such as the non-steroidal anti-inflammatory drugs may increase bone mineral through an effect on the prostaglandin system. However, possibly through an increased risk of falls, the weak analgesics are associated with an increased risk of fractures. Proton pump inhibitors may lead to a decreased calcium absorption and thus a decreased bone mineral and an increased risk of fractures.

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Osteopenia in patients infected by the human immunodeficiency virus. A case control study

Cited by 41 publications

References 7 publications

HIV Infection and Bone Mineral Density in Middle-Aged Women

HIV Infection and Bone Mineral Density in Middle-Aged Women

Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection

Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology

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