Osteopenia in HIV-infected Women Prior to Highly Active Antiretroviral Therapy

Teichmann, J.; Stéphan, E.; Lange, U.; Discher, Thomas; Friese, Georg; Lohmeyer, Jürgen; Stracke, H.; Bretzel, Reinhard G.

doi:10.1053/jinf.2002.1109

Cited by 116 publications

(97 citation statements)

References 24 publications

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“…Five 13 Below, the main individual characteristics of each article are presented. Mora et al 9 conducted a longitudinal study on 32 HIV-infected subjects exposed to HAART (highly-active antiretroviral agents), comparing them to 381 volunteers of the same age group.…”

Section: Resultsmentioning

confidence: 99%

“…BMD was significantly lower in HIV-infected subjects, but no difference was found between the therapy-naive group and the others. Teichmann et al 13 studied BMD and biochemical markers of bone metabolism in 50 HIV-infected subjects versus controls. No patient received reverse-transcriptase inhibitors or protease inhibitors, or vitamin D or calcium supplements.…”

Section: Resultsmentioning

confidence: 99%

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Reabsorção no metabolismo ósseo de pacientes HIV-positivos

2009

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INTRODUÇÃO: Pacientes infectados pelo HIV apresentam osteoporose ou osteopenia densitométrica numa taxa de 28 a 50%. O objetivo deste estudo é verificar alterações na taxa de reabsorção/formação destes pacientes. MATERIAL E MÉTODOS: Realizou-se revisão sistemática com metanálise de estudos controlados que avaliaram a associação entre osteopenia e/ou alterações no metabolismo ósseo com a infecção pelo HIV. Todos os estudos que incluíam osteocalcina ou NTX com marcadores respectivos de formação e reabsorção ósseos foram incuidos. Cinco estudos foram classificados como evidência classe III e envolveram 456 indivíduos HIV positivos e 590 controles. O NTX teve aumento significante (p < 0.00014) no grupo HIV-positivo, enquanto osteocalcina não se mostrou alterada. CONCLUSÃO: O presente estudo permite concluir que, durante a infecção pelo HIV, o marcador NTX está significantemente elevado, refletido alta atividade reabsortiva no tecido ósseo. Isto aponta um papel importante na atividade osteoclástica na perda óssea de pacientes HIV-positivos.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Reabsorção no metabolismo ósseo de pacientes HIV-positivos

2009

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“…Fewer studies have focused upon women. In studies of normal weight, ambulatory, HIV-infected women who were predominantly premenopausal, BMD was reduced in ART-naïve HIV-infected women [17] as well as in ART-experienced women [18], compared with age-matched HIV controls. However, the absolute difference in bone density was relatively modest, and prevalence of osteoporosis does not appear to be higher in ART-experienced premenopausal HIV+ women [18,19].…”

Section: Introductionmentioning

confidence: 96%

Bone mass and mineral metabolism in HIV+ postmenopausal women

et al. 2005

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The objective of this cross-sectional study was to estimate the prevalence of and risk factors for osteoporosis in HIV+ postmenopausal women. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) and biochemical indices of mineral metabolism were measured in 31 Hispanic and African American HIV+ postmenopausal women. BMD was compared with 186 historical controls, matched for age, ethnicity and postmenopausal status. Mean BMD was significantly lower at the lumbar spine and total hip in the HIV+ group, as compared with controls. Prevalence of osteoporosis was higher in the HIV+ group than controls at the lumbar spine (42% vs 23%, p=0.03) and total hip (10% vs 1%, p=0.003). Among HIV+ women, time since menopause and weight were significant predictors of BMD, while duration or class of

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“…[2][3][4][5][6][7][8][9][10][11][12][13] In a meta-analysis, the prevalence of osteoporosis, defined as a BMD T-score p À 2.5 at the spine and/or hip, was increased threefold and was higher in individuals treated with ART and those exposed to PIs when compared with their respective controls. 14 Most of these studies were conducted in North American, Australian and European populations, and few data are available for black African-infected individuals, who comprise the largest population of HIV-infected people worldwide.…”

Section: Bmd In Hiv-positive Individualsmentioning

confidence: 99%

HIV infection and osteoporosis

Compston

2015

BoneKEy Reports

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In the past two decades, the life expectancy of people living with HIV infection has increased significantly, and osteoporosis has emerged as a significant comorbidity. In addition to traditional risk factors for fracture, specific factors related to HIV infection are also likely to contribute, including antiretroviral therapy. The heterogeneity of the HIV-infected population in terms of age and ethnicity presents many challenges to the prevention and management of bone disease, and further studies are required to establish optimal approaches to risk assessment and treatment.

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Osteopenia in HIV-infected Women Prior to Highly Active Antiretroviral Therapy

Cited by 116 publications

References 24 publications

Reabsorção no metabolismo ósseo de pacientes HIV-positivos

Reabsorção no metabolismo ósseo de pacientes HIV-positivos

Bone mass and mineral metabolism in HIV+ postmenopausal women

HIV infection and osteoporosis

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