Osteonecrosis of the jaw in a patient under treatment of osteoporosis with oral bisphosphonate

Figueiredo, Marilia Andrade; Medeiros, Frederico Buhatem; Ortega, Karem L.

doi:10.4322/acr.2020.186

Cited by 4 publications

(11 citation statements)

References 23 publications

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“…Adenosine, 2'-deoxy-/ E2 ubiquitin ligase TRAF3IP2 showed good stability with a total binding free energy of −70.04 kcal mol−1, while 2-Amino-1-hydroxyoctadecan-3-one/ E2 ubiquitin ligase TRAF3IP2 demonstrated strong binding with a binding free energy of −57.76 kcal mol−1 as mentioned in Table 4. Although the same analysis for the compounds (3,5-Dihydroxyoxolan-2-yl)methyl dihydrogen phosphate and 2- (3,7,11,15,19,23,27,31-Octamethyldotriaconta-2,6,10,14,18,22,26,30octaenyl)naphthalene-1,4-dione in complex with the receptor protein E2 ubiquitin ligase TRAF3IP2 showed the total binding energies of −66.09 kcal mol− 1 and −88.71 kcal mol− 1 .…”

Section: Mmgbsa Energy Calculationsmentioning

confidence: 90%

“…Proteins of these genes were isolated and docked with the ready to dock library of compounds using MOE. The resulted compounds Adenosine, 2'-deoxy-, 2-Amino-1-hydroxyoctadecan-3-one, (3,5-Dihydroxyoxolan-2-yl)methyl dihydrogen phosphate and 2- (3,7,11,15,19,23,27,6,10,14,18,22,26,naphthalene-1,4-dione were analyzed using all the parameters like Lipinski rule of five, ADMET assay etc. ADMET analysis brings forth its absorption in the intestine, distribution, the tendency of a compound to pass through the blood-brain barrier, metabolism, and the toxicity and damage it can produce in the body.…”

Section: Discussionmentioning

confidence: 99%

“…A 20-ns molecular dynamic simulation was done to better understand the molecular mechanisms involved in the binding of Adenosine, 2'-deoxy, 2-Amino-1-hydroxyoctadecan-3-one, (3,5-Dihydroxyoxolan-2-yl)methyl dihydrogen phosphate and the ligand 2- (3,7,11,15,19,23,27,31-Octamethyldotriaconta-2,6,10,14,18,22,26,30octaenyl)naphthalene-1,4-dione in the active pocket of the 1YLA protein.…”

Section: Simulationmentioning

confidence: 99%

“…Then bone mass gradually starts to decline with the passage of age, and in women, this decline process is fast after menopause. Although bone mass is severely affected by the food qualities, diseases, and several adverse medications [7]. The human skeleton reinstates itself completely after every ten years.…”

Section: Introductionmentioning

confidence: 99%

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Screening of Phytochemicals against Osteoporosis: Molecular Docking and Simulation-Based Computational Approaches

Aloufi¹

2022

Int J Pharm Res Allied Sci

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Osteoporosis is a skeletal disorder characterized by low bone mineral density and microarchitecture deterioration, which may result in fragility and fracture risk. Osteoporosis mostly affects postmenopausal women but elderly men may also be affected. It is a silent disease and reveals at the time of fracture. It is the most prevalent bone disease in the world. Currently, there is no cure available for osteoporosis. Through a literature survey, an association is found between the overexpressed genes and osteoporosis. E2 ubiquitin ligase TRAF3IP2 is reported to be overexpressed in osteoporotic vertebral fractures. This study was designed to develop the drug targets against osteoporosis with more therapeutic efficacy and least side effects. Proteins of the overexpressed genes were searched from the PDB database. After inhibitory protein was searched from literature and used as reference protein. A library of 13000 phytochemicals was docked against novel drug targets through Molecular Operating Environment (MOE). Absorption, distribution, metabolism, excretion, and toxicological analysis were done through ADMETsar. After careful analysis top four compounds Adenosine, 2'-deoxy-, 2-Amino-1hydroxyoctadecan-3-one, (3,5-Dihydroxyoxolan-2-yl) methyl dihydrogen phosphate and 2-

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Section: Mmgbsa Energy Calculationsmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Simulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Screening of Phytochemicals against Osteoporosis: Molecular Docking and Simulation-Based Computational Approaches

Aloufi¹

2022

Int J Pharm Res Allied Sci

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“…Risedronate had the highest potency, followed by ibandronate and alendronate. Based on bone-binding affinity, alendronate has the strongest affinity, followed by ibandronate and risedronate 30 . Although the risk of MRONJ after three years of BP administration has been established 4 , 6 , MRONJ has occurred after two years of continuous ibandronate use 30 .…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of drug cessation on medication-related osteonecrosis of the jaw in patients with osteoporosis

Mustakim

Lee

et al. 2023

JKAOMS

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Objectives Suspending bisphosphonates (BPs) to reduce the risk and severity of medication-related osteonecrosis of the jaw (MRONJ) remains controversial. In this study, we quantitatively evaluated the clinical significance of BP suspension before surgery in osteoporosis patients with MRONJ. Materials and Methods We analyzed 24 osteoporosis patients with MRONJ who were treated from 2012 to 2020 at Seoul National University Dental Hospital and compared the treatment outcomes of those who suspended BPs with those who did not. The number of surgical interventions, follow-up panoramic radiographs for relative bone density measurement, and laboratory blood tests including white blood cells, erythrocyte sedimentation rate, absolute neutrophil count, hemoglobin, hematocrit, and alkaline phosphatase were analyzed. ANOVA, Student’s t -test, and Mann–Whitney U tests were used to compare results. Fisher’s exact test was used to discover the association between treatment outcome and BP suspension, and Pearson’s correlation test was used to measure the statistical relationship between the changes in serum inflammatory markers. Results The number of interventions was significantly higher in the non-drug suspension group due to recurrence ( P <0.05). The relative bone density in patients who suspended BPs was significantly different over time ( P <0.05), with the highest density at one-year follow-up. Fisher’s exact test shows an association between successful treatment outcomes and BP suspension. The alkaline phosphatase and erythrocyte sedimentation rate levels decreased significantly in the BP-suspended group, and a positive correlation was found between these elevated markers. Conclusion A significant increase in bone density throughout follow-up and a lower number of interventions were found in the BP suspension group compared to the non-drug suspension group. Also, BP suspension decreased inflammatory markers in the serum after surgery, resulting in good treatment outcomes. BP suspension is a prognostic factor for MRONJ and should be implemented before surgery.

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Influence of risedronate on orthodontic tooth movement in rodents: a systematic review and case report

MIRANDA,

FERNANDES,

SANTOS

et al. 2023

Dental Press J. Orthod.

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Introduction: Bisphosphonates have an inhibitory impact on osteoclastic activity, reducing bone resorption. However, the influence of risedronate on tooth movement is not well-defined. Objective: This systematic review assessed the effect of risedronate intake on orthodontic tooth movement. A case report was also provided. Methods: Two independent reviewers searched six databases (PubMed, Web of Science, Ovid, Lilacs, Scopus, and Open Grey). The searches were carried out in April/2020, and an update was set in place in June/2023. Therefore, the searches considered a timeline from the databases’ inception date until June/2023, with no publication date and/or language restrictions. The clinical question focused on evaluating the orthodontic tooth movement and relapse movement (Outcome) in animals (Population) exposed to risedronate (Exposure), compared to control groups (Comparison). The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were applied, and the protocol was registered in PROSPERO (CRD42020168581). The risk of bias was determined using the Systematic Review Centre for Laboratory Animal Experimentation protocol (SYRCLE). Results: Two studies in rats and one in guinea pigs were included in the systematic review. The studies reported a decrease in orthodontic tooth movement, a reduction in the relapse movement, and a reduced number of positive tartrate-resistant acid phosphatase (TRAP) cells, with a significantly reduced number of bone gaps after the administration of risedronate in rats. A case report illustrated the effects of risedronate administration in one patient. Conclusion: Based on the systematic review, risedronate seems to impair orthodontic tooth movement and relapse due to a decrease in bone resorption cells.

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Osteonecrosis of the jaw in a patient under treatment of osteoporosis with oral bisphosphonate

Cited by 4 publications

References 23 publications

Screening of Phytochemicals against Osteoporosis: Molecular Docking and Simulation-Based Computational Approaches

Screening of Phytochemicals against Osteoporosis: Molecular Docking and Simulation-Based Computational Approaches

Clinical significance of drug cessation on medication-related osteonecrosis of the jaw in patients with osteoporosis

Influence of risedronate on orthodontic tooth movement in rodents: a systematic review and case report

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