Osteonecrosis of the jaw in patients with inflammatory bowel disease treated with tumour necrosis factor alpha inhibitors

Brijs, Katrien; Miclotte, Isabel; Vermeire, Séverine; Darche, Vincent; Politis, Constantinus

doi:10.1016/j.ijom.2019.08.007

Cited by 18 publications

(21 citation statements)

References 13 publications

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“…Fang's study has shown the effects of TNFα on proliferation, angiogenesis, and osteogenesis, and osteogenesis of rat bone mesenchymal stem cells (rMSCs) 38 . TNF-α plays as a mediator of bone destruction by stimulating osteoclastogenesis [39][40][41] .…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Cheng¹,

Nie²,

Peng³

2020

Preprint

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BACKGROUNDː Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive bone disorder and its characterized by femoral head collapse and hip joint dysfunction and the biomarkers of SONFH remain unclear. The purposes of this study are to identify the significant biological function and pathway involved in SONFH, and further to search the underlying mechanism of this pathway in SONFH. METHODSː The GSE123568 dataset obtained from the Gene Expression Omnibus (GEO) database and normalized using Robust Multiarray Averaging (RMA) methods. And the Gene set enrichment analysis (GSEA), Ingenuity pathway analysis (IPA), VarElect online tool, MalaCards database, miRWalk online tool, DIANA too, and Cytoscape were integrated for bioinformatics analyses.RESULTSː 6 biological processes and 4 KEGG pathways were enriched by GSEA, and 68 candidate genes were involved in these pathways. Besides, the canonical pathway and molecule function analysis by IPA, the results revealed that 10 canonical pathways and 12 candidate genes were identified, and 20 modules and 101 candidate genes were enriched by molecule function analysis. The above candidate genes were combined and filtered using the VarElect online tool. The filtered candidate genes were overlapped with another cluster of candidate genes from the MalaCards database to identify hub genes ACP5, TNF, MMP8. Based on the hub genes, the miRNAs were screened and overlapped to predict the lncRNAs. Total 7 miRNAs of ACP5, TNF, MMP8 were targeted 956 candidate lncRNAs.CONCLUSIONSː In summary, this study identified the hub candidate genes and pathways associated with SONFH progress, and constructed the ceRNA network based on the hub candidate genes. Our findings might provide the potential biomarkers of SONFH diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Cheng¹,

Nie²,

Peng³

2020

Preprint

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“…This resulted in three patients with a definite diagnosis of MRONJ, without concomitant treatment with bisphosphonates. This study identified and described anti-TNF-α-related MRONJ occurring in a large cohort of patients with inflammatory bowel disease [18]. In the current case, mandibular osteonecrosis developed after years of infliximab treatment, without bisphosphonate administration, but in co-therapy with corticosteroids.…”

Section: Case Reportmentioning

confidence: 72%

“…However, the role of this anti-TNF-α antibody therapy to the manifestation of osteonecrosis in this case was not clearly established due to the concomitant administration of bisphosphonates. Brijs et al (2019) investigated the occurrence of MRONJ in a population of patients with inflammatory bowel disease treated with TNF-a inhibitors at a tertiary care medical center over a 24-year period [18]. These patients were cross-matched with all patients diagnosed with MRONJ.…”

Section: Case Reportmentioning

confidence: 99%

“…In the international literature, two case reports and one cohort study have already described the clinical occurrence of MRON by patients treated with infliximab [15,17,18]. In our clinical case we depict a case of extensive osteonecrosis of the jaw in a patient affected by Crohn's disease who underwent oral surgery and who had been administered infliximab therapy for several years.…”

Section: Introductionmentioning

confidence: 96%

“…The role of antiresorptives such as denosumab, bevacizumab, rituximab, adalimumab and sunitinib in the pathomechanism of MRONJ has been already described in several publications [2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Since the receptor activator of nuclear factor kappa-B ligand (RANKL) and TNF-a share some biological features and RANKL inhibition by denosumab is associated with MRONJ, TNF-a inhibition may also be associated with MRONJ [2].…”

Section: Introductionmentioning

confidence: 99%

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Osteonecrosis of the Jaw in a Crohn's Disease Patient following Infliximab Therapy: A Case Report and Literature Review

Sakkas¹

2020

J. Adv. Plast. Surg. Res.

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Introduction: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication, occurring to patients undergoing treatment with antiresorptive medication, such as bisphosphonates, denosumab or bevacizumab, for different oncologic and non-oncologic diseases. The aim of this study is to report a case of MRONJ in a young patient treated with infliximab, a tumor necrosis factor-a inhibitor used in the treatment of immune-mediated inflammatory diseases such Crohn’s disease, ulcerative colitis, ankylosing spondylitis, rheumatoid and psoriatic arthritis. Case Report: A 27-year-old female patient diagnosed with Crohn’s disease, who had been undergoing intravenous infliximab therapy every seven weeks for 8 years, sought our oral and plastic maxillofacial department with a peri-mandibular abscess for further treatment. The patient underwent surgical treatment, including the extraoral sub-mandibular incision of the abscess and the extraction of the lower second premolar under the administration of intravenous antibiotics. We traced a wound dehiscence and delayed healing procedure of the extraction’s alveolar bone, and five weeks later, the patient returned with an abscess recurrence around the mandibular angle area. The patient underwent surgical treatment with wide bone resection and debridement of the necrotic tissues. After follow-up (4 months), the patient completely healed without signs of recurrence. Discussion: Osteomyelitis of the jaw by patients treated with infliximab has been sparsely described in publications. This case confirms the potential role of infliximab in the pathogenesis of MRONJ. Since the pathomechanism of MRONJ under infliximab therapy remains unclear, we recommend a regular oral check-up before starting therapy, as well as during the therapy with infliximab, in order to possibly prevent the MRONJ onset. Keywords: Medication-Related Osteonecrosis of the Jaw, Infliximab, TNF-a Inhibitors, Crohn’s Disease and Osteomyelitis.

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Adalimumab/infliximab

2020

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Osteonecrosis of the jaw in patients with inflammatory bowel disease treated with tumour necrosis factor alpha inhibitors

Cited by 18 publications

References 13 publications

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Osteonecrosis of the Jaw in a Crohn's Disease Patient following Infliximab Therapy: A Case Report and Literature Review

Adalimumab/infliximab

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