Ostéonécrose Cortico-induite Multifocale au Cours d’une Leucémie Aigue Lymphoblastique: A Propos d’un Cas

Abstract

Osteonecrosis is recognized as one of the most common therapyrelated side effect in patients with acute lymphoblastic leukemia. Long continuous use of corticosteroid during all therapy is the major contributor to the development of osteonecrosis. To reduce osteonecrosis which is associated with debilitating long-term effects, steroid prescription should be rational. Patients should be diagnosed in early asymptomatic stages of osteonecrosis by MRI to improve prediction, management, and to prevent functional impairment. This paper focuses on reporting a case of a young adult treated with a combination of high dose corticosteroids and multi-agent chemotherapy for acute lymphoblastic leukemia. It was complicated by development of a multifocal osteonecrosis. This rare but serious complication was also briefly discussed in light of the existing literature.