Osteon remodeling dynamics in the Cayo Santiago <i>Macaca mulatta</i>: The effect of matriline

Havill, Lorena M.

doi:10.1002/ajpa.10208

Cited by 11 publications

(8 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to habitual load-complexity and habitual strain-mode distributions, effects associated with aging, sex, and body weight (discussed below), and genetic variations and developmental constraints that could influence the emergence of specific histomorphological characteristics and/or their regional distribution might help to explain the frequent misclassifications among the nonhuman comparisons (Bromage and Boyde, 1998;de Margerie et al, 2002;Havill, 2003;Havill et al, 2013;Lee, 2004;Starck and Chinsamy, 2002;Warshaw, 2007). For example, a study of middleaged human female twins found between 55 and 62% of remodeling marker differences are attributable to genetic factors (Bjørnerem et al, 2015; remodeling markers included: serum osteocalcin, C-terminal cross-linking telopeptide of type I collagen, and procollagen type I Nterminal propeptide).…”

Section: Discussionmentioning

confidence: 99%

Utility of osteon circularity for determining species and interpreting load history in primates and nonprimates

Keenan¹,

Mears²,

Skedros

2017

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of osteon circularity for determining species and interpreting load history in primates and nonprimates

Keenan¹,

Mears²,

Skedros

2017

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…Advances in statistical genetics over the past decade have expanded the scope of anthropological inquiry to include the examination of the determinants of skeletal morphology, growth, and development. Recent study by anthro-pological geneticists has focused on craniofacial and dental traits (Hlusko et al, 2002;Hlusko and Mahaney, 2003;Roseman et al, 2010;Sherwood et al, 2011), and nonhuman primate bone phenotypes (Cheverud and Buikstra, 1981;Kohn et al, 2001;Havill, 2003;Havill et al, 2005Havill et al, , 2010. These works have contributed to our knowledge of the genetic underpinnings of skeletal growth and development, as well as the evolutionary implications of such foundations.…”

Section: The Genetic Landscapementioning

confidence: 99%

Skeletal growth and the changing genetic landscape during childhood and adulthood

Duren

Šešelj

Froehle

et al. 2012

American J Phys Anthropol

View full text Add to dashboard Cite

Growth, development, and decline of the human skeleton are of central importance to physical anthropology. All processes of skeletal growth (longitudinal growth as well as gains and losses of bone mass) are subject to environmental and genetic influences. These influences, and their relative contributions to the phenotype, can be asserted at any stage of life. We present here the gross phenotypic and genetic landscapes of four skeletal traits, and show how they vary across the life span. Phenotypic sex differences are found in bone diameter and cortical index (a ratio of cortical thickness over bone diameter) at a very early age and continue throughout most of life. Sexual dimorphism in summed cortical thickness and bone length, however, is not evident until shortly after the pubertal growth spurt. Genetic contributions (heritability) to these skeletal phenotypes are generally moderate to high. Bone length and bone diameter (which both scale with body size) tend to have the highest heritability, with heritability of bone length fairly stable across ages (with a notable dip in early childhood) and that of bone diameter peaking in early childhood. The bone traits summed cortical thickness and cortical index, that may better reflect bone mass, a more plastic phenomenon, have slightly lower genetic influences, on average. Results from our phenotypic and genetic landscapes serve three key purposes: demonstration of the integrated nature of the genetic and environmental underpinnings of skeletal form; identification of periods of bone’s relative sensitivity to genetic and environmental influences; and stimulation of hypotheses predicting the effects of exposure to environmental variables on the skeleton, given variation in the underlying genetic architecture.

show abstract

“…Blomquist, 2009; Havill, 2003; Cheverud et al, 1990]. Previous work on the heritability of female lifetime fitness ( n = 590) in the population produced some unexpected results suggesting weak maternal influences on early life mortality [cf.…”

Section: Introductionmentioning

confidence: 99%

Maternal Effects on Offspring Mortality in Rhesus Macaques (Macaca mulatta)

Blomquist

2013

American J Primatol

View full text Add to dashboard Cite

The genetics of primate life histories are poorly understood, but quantitative genetic patterns in other mammals suggest phenotypic differences among individuals early in life can be strongly affected by interactions with mothers or other caretakers. I used generalized linear mixed model extensions of complex pedigree quantitative genetic techniques to explore regression coefficients and variance components for infant and juvenile mortality rates across pre-reproductive age classes in the semi-free ranging Cayo Santiago rhesus macaques. Using a large set of records (max. n=977 mothers, 6240 offspring), strong maternal effects can be identified early in development but they rapidly “burn off” as offspring age and mothers become less consistent buffers from increasingly prominent environmental variation. The different ways behavioral ecologists and animal breeders have defined and studied maternal effects can be subsumed, and even blended, within the quantitative genetic framework. Regression coefficients identify loss of the mother, maternal age, and offspring age within their birth cohort as having significant maternal effects on offspring mortality, while variance components for maternal identity record significant maternal influence in the first month of life.

show abstract

Osteon remodeling dynamics in the Cayo Santiago Macaca mulatta: The effect of matriline

Cited by 11 publications

References 47 publications

Utility of osteon circularity for determining species and interpreting load history in primates and nonprimates

Utility of osteon circularity for determining species and interpreting load history in primates and nonprimates

Skeletal growth and the changing genetic landscape during childhood and adulthood

Maternal Effects on Offspring Mortality in Rhesus Macaques (Macaca mulatta)

Contact Info

Product

Resources

About