Osteomyelofibrosis/-sclerosis: A histological and cytogenetic study on core biopsies of the bone marrow

Georgii, A.; Thiele, Jürgen; Vykoupil, K. F.

doi:10.1007/bf00430655

Cited by 19 publications

(12 citation statements)

References 39 publications

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“…"6 Chronic myeloid leukaemia usually causes some degree of osteopenia. Osteolytic lesions, some associated with imminent blastic transformation have also been described.74 [117][118][119][120] In our own studies lytic osseous lesions were observed in association with focal accumulations of megakaryoblasts and megakaryocytes. 74 When the bone marrow histology shows a predominance of granulocyte precursors, there is a greater likelihood of transformation to a blast crisis.…”

Section: Chronic Myeloid Leukaemiamentioning

confidence: 82%

Bone biopsy in haematological disorders.

Burkhardt¹,

Frisch²,

Bartl³

1982

J Clin Pathol

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SUMMARY Bone marrow biopsies are now widely used in the investigation and follow-up of many diseases. Semi-thin sections of 8216 undecalcified biopsies of patients with haematological disorders were studied. Observations were made on the cytopenias and the myelodysplastic syndromes, the acute leukaemias and the myeloproliferative disorders, Hodgkin's disease and the malignant lymphomas including multiple myeloma, hairy cell leukaemia and angioimmunoblastic lymphadenopathy. Bone marrow biopsies are essential for the differential diagnosis of most cytopenias and for the early recognition of fibrosis which most frequently occurred as a consequence of megakaryocytic proliferation in the myeloproliferative disorders. Different patterns of bone marrow involvement were found in the lymphoproliferative disorders and both their type and extent constituted factors of prognostic significance. A survey of the literature is given and the conclusion is drawn that bone marrow biopsies provide indispensible information for the diagnostic evaluation and the follow-up of patients with haematological disorders.

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Section: Chronic Myeloid Leukaemiamentioning

confidence: 82%

Bone biopsy in haematological disorders.

Burkhardt¹,

Frisch²,

Bartl³

1982

J Clin Pathol

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“…Intravascular hematopoiesis conspicuously present in distended sinusoids of the bone marrow in AMM has been formerly described by several authors (Buyssens and Bourgeois, 1977;Georgii et al, 1980;Burkhardt et al, 1984;Wolf and Neiman, 1985). This feature was frequently encountered in overt stages of AMM (corresponding with our group I1 patients) and is thought to provide hematopoietic cells access to the circulation and thus results in a leukoerythroblastic reaction.…”

Section: Histological Studiesmentioning

confidence: 90%

Agnogenic myeloid metaplasia (AMM)—correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients

Thiele¹,

Zankovich²,

Steinberg³

et al. 1989

Hematological Oncology

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A clinicopathological study was performed on 114 patients (46 male/68 female, median age 67 years) with the diagnosis of agnogenic myeloid metaplasia (AMM) respectively primary osteo-myelofibrosis which was not preceded by any other or allied subtype of chronic myeloproliferative disorders. On admission patients revealed a striking variability of laboratory data as well as different histopathological features of initial bone marrow biopsies. For this reason discrimination was done into two groups based on bone marrow findings: group I patients (n = 46, 19 male/27 female) showed a hypercellular marrow without or only borderline (n = 24) to slight (n = 22) reticulin fibrosis and group II cases (n = 68, 27 male/41 female) displayed coarse bundles of collagen fibres (n = 18) frequently accompanied by osteosclerosis (n = 50). Statistical analysis of the corresponding initial hematological findings resulted in significant differences. These differences concerned also the complications occurring during the lengthy course of disease, which included a higher incidence of pancytopenia and severe marrow failure with hemorrhage and blast crisis in group II patients. However, overall survival time was not different in both groups. This may be related to the similarity of age distribution (64 resp. 65 years) and its significant association with arteriosclerotic vascular lesions. Consequently acute myocardial infarction and congestive heart failure were frequent causes of death in addition to infections due to marrow failure and blast crisis. Repeated bone marrow biopsies in 24 patients revealed an insidious transition from hypercellular lesions (group I) into advanced fibro-osteosclerotic changes (group II) concurring with laboratory data. Therefore our discrimination into two groups of patients represents variable stages or static histological and corresponding hematologic features in the evolution of a dynamic disease process in AMM.

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“…The pres ence or absence of Ph1 in MF/OMS is still a subject of discussion. Whereas Georgiiet al [10] observed Ph1 in 67% (22 of 33) of bone marrow biopsies from patients with MF/OMS in other investigations it was not observed in peripheral blood or bone marrow cells [6,18,27].…”

Section: Discussionmentioning

confidence: 92%

Trisomy lq and Loss of Y Chromosome in a Male with Osteomyelosclerosis

Bauchinger¹

1984

Acta Haematol

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The results of a cytogenetic analysis of peripheral blood cells in a 61-year-old male with histopathologically documented osteomyelosclerosis, hepatosplenomegaly, ascites and anemia are described. The karyotype 46, X,-Y+ 1p22→qter, without Ph¹-chromosome, was observed in all unstimulated and in most PHA-stimulated cells. The patient had not received cytostatic or radiation therapy, thus the marker lq+ could not have resulted from such clastogenic treatments.

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Osteomyelofibrosis/-sclerosis: A histological and cytogenetic study on core biopsies of the bone marrow

Cited by 19 publications

References 39 publications

Bone biopsy in haematological disorders.

Bone biopsy in haematological disorders.

Agnogenic myeloid metaplasia (AMM)—correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients

Trisomy lq and Loss of Y Chromosome in a Male with Osteomyelosclerosis

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