Osteomyelitis Variolosa: A Case Report

Douraiswami, Balaji

doi:10.1177/230949901101900128

Cited by 13 publications

(14 citation statements)

References 4 publications

(6 reference statements)

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“…A Arora, A Agarwal, S Kumar (2008) 3 2 Pathological fracture, Secondary arthritis Humerus, radius, ulna, ankle, feet Douraiswami Balaji (2011) 4 1 Secondary arthritis Distal femur, patella, humerus, metacarpals, ankle. Nema et al (2011) 5 1 Secondary arthritis Distal Humerus, Metacarpals, metatarsals, phalynx, calcaneum Andrews et al 2011 8 1 Asymptomatic Humerus, radius, Ulna, metacarpals Mugalur et al (2015) 6 1 Secondary arthritis Humerus, radius, Ulna, Metacarpals, ankle Singh PK 2012 9 1 Pathological fracture Humerus, radius, Ulna, Metacarpals Thomas J 2017 7 1 Secondary arthritis Humerus, radius, Ulna, Metacarpals, ankle Present study 1 Asymptomatic incidental finding Humerus, radius, Ulna, malformation of the bones (frequently with an intact joint space), flail joints and ultimately osteoarthritis.…”

Section: Studies and Number Of Cases Patients Presentation Bones Affementioning

confidence: 99%

“…5,6,8,9 There is deformity, instability and disorganization around the wrist and ankle joint caused by the disease process. 3,4,6,7 Ankle involvement is further complicated by collapse of the talus. 4 Arora et al 3 and Singh 9 reported a distal humerus fracture around the elbow affected with osteomyelitis variolosa, which was managed operatively.…”

Section: Studies and Number Of Cases Patients Presentation Bones Affementioning

confidence: 99%

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Osteomyelitis variolosa: Forgotten complication of an eradicated disease

Khurana

Vardhan

Negi

2019

Journal of Clinical Orthopaedics and Trauma

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Background: Orthopedic manifestations and sequelae of small pox disease are largely forgotten. Presening features in the modern era are not only the classical deformities but also includes precocious arthritis, pathological fractures and joint instability. Objectives: To conduct a thorough and systematic review of the literature for all articles reporting osteomyelitis variolosa and its sequelae post eradication and to present an additional case as an illustration. Study design: Systematic review and case report. Method: ology: PubMed, EMBASE and Google Scholar databases were searched for relevant articles using different combinations of the keywords till 20th June 2017. All articles reporting cases of osteomyelitis variolosa following small pox eradication were included. Pearling of the bibliographies of selected articles was conducted to locate articles missed by the primary database search. Data from these reports were collected on pre-defined forms and the results were analysed. Results: A total of 8 cases have been reported in the literature so far post-eradication of small pox and all cases are from India. These cases have predominant involvement of elbow followed by hands, feet and ankle. Characteristic clinical signs in the present era are secondary arthritis, pathological fractures, joint instability and some cases even have incidental presentation. The diagnosis is further confirmed by plain radiographs which show pathognomonic features of this condition. Rate of missed/misdiagnosis is very high due to rarity of this condition. All cases in the published literature were managed conservatively except those presenting with pathological fracture. Conclusions: The purpose of this study is to remind clinicians of an easily recognised sequelae of an eradicated disease and make them aware of its complications.

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Section: Studies and Number Of Cases Patients Presentation Bones Affementioning

confidence: 99%

Section: Studies and Number Of Cases Patients Presentation Bones Affementioning

confidence: 99%

Osteomyelitis variolosa: Forgotten complication of an eradicated disease

Khurana

Vardhan

Negi

2019

Journal of Clinical Orthopaedics and Trauma

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“…Balaji [ 7 ] reported one such case in a 70-years-old woman with hypoplastic lateral femoral condyle of the right knee, patella baja, ankylosed right elbow, dislocated left elbow with multidirectional instability, short third and fourth metacarpals of the left hand, bilateral valgus deformity of ankle with destruction of talus. Arora et al .…”

Section: Discussionmentioning

confidence: 99%

Excellent Functionality Despite Clinico-Radiological Deformity in Osteomyelitis Variolosa - A Case Report

Mugalur

Shahane

Samant

et al. 2015

TOORTHJ

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Despite the eradication of smallpox from the world in 1980 the osteo-articular sequelae of smallpox are still occasionally noticed in previously endemic areas. The sequelae of osteomyelitis variolosa may raise a diagnostic challenge to the untrained eyes of the surgeon. We present a case of “osteomyelitis variolosa” in a 70 years old patient. The patient had bilateral dislocation of the elbow joint with multidirectional instability. There was distortion of the articular surfaces and ankylosis of the bilateral proximal radio-ulnar joint. Hypoplasia of the right ulna with short fourth and fifth metacarpals of the left hand and hypoplasia of right fourth metacarpal with cortical thickening was noted radiologically. The patient had minimal disability of his elbows despite the striking radiological abnormality and was functionally independent.

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“…13–15 Bone infections caused by Brucella suis , 16 Haemophilus influenzae , 17 Mycobacterium tuberculosis , 18 Mycobacterium ulcerans , 19 and pox viruses, 20,21 as well as those whereby bone lesions are secondary to Bacille Calmette-Guérin 22 or smallpox 23 vaccination, also have been reported in the literature. Although many gram-negative and gram-positive bacteria were reported to have caused osteomyelitis; the great majority of bone infections, however, is staphylococcal in origin and mostly caused by a single bacterium: Staphylococcus aureus .…”

Section: Pathologies and The Downsides Of The Traditional Clinicamentioning

confidence: 96%

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

Uskoković

2015

Crit Rev Ther Drug Carrier Syst

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This article provides a critical view of the current state of the development of nanoparticulate and other solid-state carriers for the local delivery of antibiotics in the treatment of osteomyelitis. Mentioned are the downsides of traditional means for treating bone infection, which involve systemic administration of antibiotics and surgical debridement, along with the rather imperfect local delivery options currently available in the clinic. Envisaged are more sophisticated carriers for the local and sustained delivery of antimicrobials, including bioresorbable polymeric, collagenous, liquid crystalline, and bioglass- and nanotube-based carriers, as well as those composed of calcium phosphate, the mineral component of bone and teeth. A special emphasis is placed on composite multifunctional antibiotic carriers of a nanoparticulate nature and on their ability to induce osteogenesis of hard tissues demineralized due to disease. An ideal carrier of this type would prevent the long-term, repetitive, and systemic administration of antibiotics and either minimize or completely eliminate the need for surgical debridement of necrotic tissue. Potential problems faced by even hypothetically “perfect” antibiotic delivery vehicles are mentioned too, including (i) intracellular bacterial colonies involved in recurrent, chronic osteomyelitis; (ii) the need for mechanical and release properties to be adjusted to the area of surgical placement; (iii) different environments in which in vitro and in vivo testings are carried out; (iv) unpredictable synergies between drug delivery system components; and (v) experimental sensitivity issues entailing the increasing subtlety of the design of nanoplatforms for the controlled delivery of therapeutics.

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Osteomyelitis Variolosa: A Case Report

Cited by 13 publications

References 4 publications

Osteomyelitis variolosa: Forgotten complication of an eradicated disease

Osteomyelitis variolosa: Forgotten complication of an eradicated disease

Excellent Functionality Despite Clinico-Radiological Deformity in Osteomyelitis Variolosa - A Case Report

Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis

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