Osteomyelitis of the sustentaculum tali in horses: 10 cases (1992–1998)

Dr, Hand; Jp, Watkins; Cm, Honnas; D, Kemper

doi:10.2460/javma.2001.219.341

Cited by 24 publications

(22 citation statements)

References 7 publications

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“…It has been seen that pathological changes occur in experimentally-induced arthritis, such as the development of multiple epitheloid cell granulomas or granulomatous lesions containing fibrin deposits, new bone synthesis, and the destruction of the trabeculum [34,35]. The increased ampicillin levels due to the effect of NSAID administration may be due to damage to the bone matrix caused by the inflammatory process and facilitated ampicillin influx [36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Adjuvant arthritis-induced changes on ampicillin binding in serum and tissues under the influence of non-steroidal anti-inflammatory drugs in rats

Tigka

Daskala

Rallis

et al. 2005

European Journal of Drug Metabolism and Pharmacokinetics

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Adjuvant arthritis, as a model for investigating rheumatoid arthritis (RA), is characterized by reduced plasma albumin levels and interferes with drug binding in the plasma and tissues (liver and bone). Ampicillin interacts with non-steroidal anti-inflammatory drugs (NSAIDs) due to the acidic pk(a). The aim of this study was to investigate in vitro the concentrations of ampicillin in the serum, femur, mandible and liver proteins following the co-administration of ketoprofen, flurbiprofen, ibuprofen, oxyphenbutazone and ASA in adjuvant arthritis versus healthy control rats. Ampicillin binding was found to be reduced in the serum of arthritic rats, and ampicillin binding to serum proteins was also reduced under the influence of NSAIDs in the control animals. Differences in ampicillin binding were observed in the various tissues due to the effect of adjuvant arthritis as well as that due to the co-administration of NSAIDs. In conclusion, this in vitro study may provide a plausible explanation for the ampicillin-NSAIDs interaction and such a finding may be of therapeutic significance in the treatment of painful arthritic disease such as RA.

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Section: Discussionmentioning

confidence: 99%

Adjuvant arthritis-induced changes on ampicillin binding in serum and tissues under the influence of non-steroidal anti-inflammatory drugs in rats

Tigka

Daskala

Rallis

et al. 2005

European Journal of Drug Metabolism and Pharmacokinetics

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“…Eine chirurgische Entfernung der Knochenzubildung nach vollständiger Eröff-nung der TBSS (Welch et al 1990) oder über einen minimal invasiven Zugang (Cauvin et al 1999) (Whitton und Kannegieter 1995, Dik und Leitch 1995, Torre und Bekker 1996, Minshall und Wright 2012. Sie werden im Englischen manchmal als "false thouroughpin" bezeichnet, jedoch ist diese Bezeichnung uneinheitlich definiert (Dik und Keg 1990, Blumeshine und Dyson 1997, Cauvin 2010 (Santschi et al 1997, Cauvin et al 1999, Hand et al 2001. Eine assoziierte Osteomyelitis des Sustentaculum tali erfordert zusätzlich ein Débridement des Knochens.…”

Section: Diskussionunclassified

“…Eine assoziierte Osteomyelitis des Sustentaculum tali erfordert zusätzlich ein Débridement des Knochens. Die Prognose dafür reicht von schlecht (MacDonald et al 1989) bis gut, teils sogar bis exzellent (Santschi et al 1997, Hand et al 2001. Die Durchtrennung des sechs bis acht cm langen Retinaculum flexorum für einen besseren Zugang zur TBSS ist ohne klinische Konsequenz (Santschi et al 1997).…”

Section: Diskussionunclassified

“…Septische (Dik und Merkens 1987, Torre und Becker 1996, Hand et al 2001) und aseptische (van Pelt 1969, Edwards 1978, Welch et al 1990, Santschi et al 1997, Archer et al 2004, Minshall und Wright 2012 Erkrankungen der TBSS sind in der Literatur beschrieben. Die septische Tenosynovitis hat, wie alle Infektionen synovialer Strukturen, eine große klinische und prognostische Bedeutung und muss rechtzeitig diagnostiziert und behandelt werden.…”

Section: Introductionunclassified

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Disease of the tarsal sheath in 13 horses

Delling¹,

Huth²,

Stiller³

et al. 2013

PHK

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Disease of the tarsal sheath in 13 horsesThe tarsal sheath is a relatively large structure and has an exposed position on the medial aspect of the hock in horses. Because of that, it may be affected by various diseases. The precise knowledge of anatomical location, extend and relationship to surrounding structures and diagnostic modalities is an important prerequisite to diagnose those conditions. The goal of the present study was to illustrate and document the anatomical details in cadaver limbs. Furthermore, a retrospective analysis of all cases with tarsal sheath involvement presented to the Large Animal Clinic for Surgery, Faculty of Veterinary Medicine, University of Leipzig in a seven year period (2005-2011) was performed. A detailed anatomical description of the tarsal sheath based on our own evaluation as well as literature findings is presented. It was noted that the description of the anatomical situation in the present literature is neither consistent, nor precise and partly outdated. Among patients presented to our hospital, diseases of the tarsal sheath have a low incidence (0.3 %). Based on the clinical findings, most cases could be allocated to one of four groups: 1) acute to chronic, subclinical aseptic tenosynovitis, 2) chronic, clinical apparent, aseptic tenosynovitis, 3) acute, septic tenosynovitis due to laceration, and 4) acute tenosynovitis secondary due to cellulitis. Some conditions warrant immediate and comprehensive treatment whereas other conditions have a low clinical relevance and may heal on their own. Prognoses for life, for full athletic function as well as cosmetic appearance of the hock vary considerably among the diseases affecting the tarsal sheath.Keywords: tarsal sheath / tenosynovitis / hock / thoroughpin / lateral digital flexor tendon / orthopedics U. Delling et al. Einleitung

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“…However, osteomyelitis in the hock region of the mature horse has been more commonly reported in association with sustentacular pathology (Dik and Merken ; Hand et al . ), the tuber calcanei (MacDonald et al . ; Hand et al .…”

Section: Introductionmentioning

confidence: 99%