Osteomyelitis: Diagnosis with^99mTc-labeled Antigranulocyte Antibodies Compared with Diagnosis with¹¹¹In-labeled Leukocytes—Initial Experience

Abstract

Use of the monoclonal antigranulocyte antibody was comparable to the use of (111)In-labeled leukocytes in the diagnosis of appendicular skeletal osteomyelitis. The combined results of the monoclonal antibody study and bone scanning were more accurate (0.91) for diagnosing this entity than were the results of any of the other studies.

White blood cell scintigraphy for differentiation of infection and aseptic loosening: A retrospective study of 76 painful hip prostheses

“…In histopathological analysis, the inflammatory reaction accompanying the infected prosthesis is identical to that present in aseptic loosening, with one important difference: neutrophils, usually absent in aseptic loosening, are often present in large numbers during infection (Tsukayama et al 1996, Lonner et al 1996. At least in theory, labeled white blood cell imaging is particularly well suited to distinguish between the inflamed aseptically loosened prosthesis (in which neutrophils are generally absent) and the infected prosthesis (in which neutrophils are present) (Palestro et al 2002).…”

SPECT/CT-Infektdiagnostik am Skelett

“…In solchen Fällen erlaubt die IS, die Ansammlungen markierter Leukozyten im Infekt nachweist, eine spezifischere Beurteilung. Kommerziell erhältliche Kitpräparationen für die In-vivo-Markierung von Granulozyten bieten eine ähnliche diagnostische Genauigkeit wie die aufwendigere In-vitro-Markierung autologer Leukozyten [2,3,15] und ermöglichen Infektszintigraphien auch in Instituten ohne entsprechende Laborausstattung. Die Aufnahmezeitpunkte bei der im deutschsprachigen Raum hauptsächlich verwendeten IS mit Antigranulozytenantikörpern sind bei 4-6 und 24 h p.i.…”

Nuclear Medicine Procedures in the Diagnosis of Orthopedic Infections

“…At least one of these, an antibody produced in mice tagged with 99m Tc that binds to human polymorphonuclear leukocyte CD15 antigen, has been used successfully to detect osteomyelitis with high sensitivity and specificity. 21 Disadvantages of these monoclonal antibody agents are slow clearance from the blood requiring delayed imaging, and the possible development of human anti-mouse antibodies which may alter the biodistribution in the same patient of future imaging agents using anti-mouse antibody agents, and human anti-mouse antibodies can also interfere with immunoassay measurements used to measure hormones and other substances in blood. 22,23 Currently, these agents are not commonly used clinically.…”