Osteomyelitis and Osteonecrosis of the Jaws

Goupil, Michael T.; Banki, Mohammad; Ferneini, Elie M.

doi:10.1016/b978-0-323-28945-0.00013-2

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…However, unlike PD in humans, MPPD commonly progresses to necrotising osteomyelitis of the mandible or maxilla, with the formation of sequestra and proliferation of subperiosteal bone subsequently leading to bone deformity in the jaw (the characteristic ‘lumpy jaw’). The progression to osteomyelitis, suppurative inflammation and necrosis of adjacent soft tissues observed in macropods is rare in humans 3 , 28 . In humans, early colonisers, such as Streptococcus spp.…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas spp., Fusobacterium spp., and Bacteroides spp. dominate microbiota in the course of macropod progressive periodontal disease

Yip

Mohammadi‐Dehcheshmeh

McLelland

et al. 2021

Sci Rep

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Macropod progressive periodontal disease (MPPD) is a necrotizing, polymicrobial, inflammatory disease commonly diagnosed in captive macropods. MPPD is characterized by gingivitis associated with dental plaque formation, which progresses to periodontitis and then to osteomyelitis of the mandible or maxilla. However, the underlying microbial causes of this disease remain poorly understood. In this study, we collected 27 oral plaque samples and associated clinical records from 22 captive Macropodidae and Potoroidae individuals that were undergoing clinical examination at Adelaide and Monarto Zoos in South Australia (15 healthy, 7 gingivitis and 5 periodontitis-osteomyelitis samples). The V3-V4 region of the 16S ribosomal RNA gene was sequenced using an Illumina Miseq to explore links between MPPD and oral bacteria in these animals. Compositional differences were detected between the microbiota of periodontitis-osteomyelitis cases compared to healthy samples (p-value with Bonferroni correction < 0.01), as well as gingivitis cases compared to healthy samples (p-value with Bonferroni correction < 0.05) using Permutational Multivariate Analysis of Variance (PERMANOVA). An overabundance of Porphyromonas, Fusobacterium, and Bacteroides taxa was also identified in animals with MPPD compared to healthy individuals using linear discriminant analysis effect size (LEfSe; p = < 0.05). An increased abundance of Desulfomicrobium also was detected in MPPD samples (LEfSe; p < 0.05), which could potentially reflect differences in disease progression. This is the first microbiota analysis of MPPD in captive macropods, and these results support a polymicrobial pathogenesis of MPPD, suggesting that the microbial interactions underpinning MPPD may be more complex than previously documented.

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Section: Discussionmentioning

confidence: 99%

Porphyromonas spp., Fusobacterium spp., and Bacteroides spp. dominate microbiota in the course of macropod progressive periodontal disease

Yip

Mohammadi‐Dehcheshmeh

McLelland

et al. 2021

Sci Rep

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“…Thus, sequestrectomy reduces the bioburden, prevents further spread and the establishes a good blood supply to the remaining bone enabling host defense mechanisms and the antibiotics administered to reach the site. 16 It is therefore imperative to maintain good blood supply to the remaining bone. Extraoral approaches by resection of mandible leads to extensive periosteal and muscular stripping compromising the centripetal blood supply in an already compromised centrifugal blood supply from the Inferior alveolar artery due to resection.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to a further compromise in the blood supply that makes it impossible for the host defense mechanisms to reach the site leading to the progressive nature of the disease. Thus, sequestrectomy reduces the bioburden, prevents further spread and the establishes a good blood supply to the remaining bone enabling host defense mechanisms and the antibiotics administered to reach the site 16 . It is therefore imperative to maintain good blood supply to the remaining bone.…”

Section: Discussionmentioning

confidence: 99%

Degloving Approach for the Management of Extensive Mandibular Osteomyelitis

Sharma

Grewal³

2020

Journal of Craniofacial Surgery

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Extensive osteomyelitis of the mandible is usually managed using elaborate procedures including resection and reconstruction of the affected part of the mandible. This brief clinical report, the authors present a case of 75-year old male with extensive osteomyelitis of the mandible, incidentally diagnosed with anemia of chronic disease and Type I diabetes mellitus and managed using an intraoral degloving approach exclusively. This has proved to be a procedure ensuring better blood supply, decreased morbidity, precluding an elaborate reconstruction procedure and an overall reduction in cost. The advantages, scientific basis, rationale and pitfalls have been discussed briefly.

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Imaging of dental infections

Patel

Haymes

et al. 2021

Emerg Radiol

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Osteomyelitis and Osteonecrosis of the Jaws

Cited by 3 publications

References 17 publications

Porphyromonas spp., Fusobacterium spp., and Bacteroides spp. dominate microbiota in the course of macropod progressive periodontal disease

Porphyromonas spp., Fusobacterium spp., and Bacteroides spp. dominate microbiota in the course of macropod progressive periodontal disease

Degloving Approach for the Management of Extensive Mandibular Osteomyelitis

Imaging of dental infections

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