Osteomyelitis: A manifestation of sickle cell anemia

AlDallal, Salma M

doi:10.15761/cmi.1000132

Cited by 8 publications

(10 citation statements)

References 25 publications

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“…Untreated, chronic osteomyelitis can lead to severe bone damage, life-threatening infections and a decreased quality of life. 20 Due to the extensive mandibular involvement, surgical excision was not an ideal management option in both our cases requiring the need to consider alternatives.…”

Section: Discussionmentioning

confidence: 91%

Sickle cell osteomyelitis: A novel approach and review of the literature

2020

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Aim: Sickle cell disease is a well-recognized risk factor for the development of osteomyelitis. Its occurrence in the mandible is both complex and challenging. Antibiotics and surgery remain the main treatment modalities, but both have varying success in refractory osteomyelitis. With increasing individual clinical cases highlighting the successful management of both primary and secondary chronic osteomyelitis with bisphosphonate therapy, it was considered a viable last line trial medication prior to aggressive surgery in refractory sickle cell osteomyelitis.Materials and methods: Two cases are retrospectively reported for the use of oral bisphosphonates.Results: Both cases showed positive outcomes both clinically and radiographically in response to oral bisphosphonates with no recurrence of acute episodes even on the background of recurring sickle crises. Conclusion:The current cases are the first in the literature to report successful management of sickle cell osteomyelitis with oral bisphosphonates and explores the literature on previous reports of the condition.

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Section: Discussionmentioning

confidence: 91%

Sickle cell osteomyelitis: A novel approach and review of the literature

2020

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“…Due to this sickle shaped RBC they can manifest with multisystem complication like splenic sequestration, sickle cell pain (Dactylytis), osteomyelitis, avascular necrosis, priapism, stroke and acute chest syndrome. 5 Hepatobiliary complications of SCD are not well established in pediatric age group. Allali et al in their cohort retrospective study on 616 SCD pediatric patients reported 37% of the children developed one hepatobiliary complication.…”

Section: Discussionmentioning

confidence: 99%

Hepatopathy in sickle cell disease with osteomyelitis: a challenging diagnosis: case report

Sushmitha

Nazir

Sreekantham

et al. 2023

Int J Contemp Pediatr

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‘Sickle hepatopathy’ is a condition which is seen in only 10% cases of sickle cell disease (SCD). Sickle hepatopathy could be due to acute sickle crisis, sequestration, cholangiopathy, severe intrahepatic cholestasis or as a result of chronic blood transfusion related infection and hemosiderosis. Differentiating the cause for hepatopathy in SCD is challenging. Hepatopathy manifestation can range from mild liver function test abnormality to life threatening fulminant hepatic failure. Hence, demanding prompt recognition and management. Here we reported a one such case of 13 year old male with progressing jaundice and bony pain with swelling of lower limbs was diagnosed as SCD with right proximal tibia sickle osteomyelitis and left knee septic arthritis with hepatopathy who was managed with supportive care and surgical intervention.

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“…Radiographic findings of osteopenia, sclerosis, and periosteal inflammation are seen in both stages of infection and infarction. Therefore, the radiographic features are nonspecific and primarily normal [4] [5]. We report the case of a three-year-old female sickle cell patient with chronic bone pain, which was later diagnosed as chronic osteomyelitis and cared for.…”

Section: Introductionmentioning

confidence: 97%

“…The infection is haematogenous in nature due to its delayed onset. Immunodeficiency caused by splenic dysfunction, tissue infarction, and excess iron content leads to an increased risk of osteomyelitis [4]. In SCA, osteomyelitis diagnosis can be a major problem for healthcare providers, where unsuccessful identification of the disease may end up with severe bone damage and progression of infection to life-threatening status.…”

Section: Introductionmentioning

confidence: 99%

Osteomyelitis in Children with Sickle Cell Disease: A Challenging Diagnosis: Case Report from Cameroon

Yolande¹,

Tufong²,

Jules³

et al. 2021

OJPed

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Introduction: Sickle Cell Disease (SCD) is the most prevalent genetic disease in the world predominantly in the African population with Sickle Cell Anaemia (SCA) being its dominant form. One of the most frequent complications of SCD is osteomyelitis. SCA is due to a point mutation in the beta globin chain of haemoglobin. This is responsible for the sickled shape of RBCs under low oxygen tension conditions leading to obstruction in the microcirculation. This leads to vaso-occlusive crises (VOC) which has a similar clinical presentation to that of osteomyelitis, another complication of SCD. Case Presentation: We present the case of a three-year-old girl with SCA who presented with an inability to bear weight in a febrile context. A diagnosis of VOC was initially made, which was later on changed to both a left chronic tibial and right distal femoral osteomyelitis following a series of biological, and imaging investigations. Surgical debridement and drainage were performed, resulting 9 weeks later in the involution of fever and leg pain. Conclusion: Osteomyelitis when associated with SCD is a dreadful and deathly disease in low income countries as it also presents like VOC therefore higher suspicion index is recommended. It is therefore important to take this into consideration at an early stage in patients with homozygous sickle cell disease so as to rapidly

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Osteomyelitis: A manifestation of sickle cell anemia

Cited by 8 publications

References 25 publications

Sickle cell osteomyelitis: A novel approach and review of the literature

Sickle cell osteomyelitis: A novel approach and review of the literature

Hepatopathy in sickle cell disease with osteomyelitis: a challenging diagnosis: case report

Osteomyelitis in Children with Sickle Cell Disease: A Challenging Diagnosis: Case Report from Cameroon

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