Osteomyelitis

Goodrich, Laurie R.

doi:10.1002/9781119108757.ch48

Cited by 3 publications

(11 citation statements)

References 86 publications

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“…The use of implant material in a heavily contaminated environment frequently results in infection and loss of stability of the implants (Goodrich, 2020). Therefore, it was opted in this case to use a two‐stage approach, where the purpose of the first stage was to eliminate infection and provide the opportunity to obtain some joint stabilisation by the formation of scar tissue.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of a severely contaminated open metatarsophalangeal joint luxation by arthrodesis

Haspeslagh

Schauvliege

Martens

2021

Equine Veterinary Education

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Summary A horse with an open medial luxation of the left metatarsophalangeal joint with extensive cartilage and soft tissue damage and severe contamination of the wound was treated with a two‐stage approach. In the first stage, the lesion was cleaned, the luxation was reduced, the wound was sutured and the limb was kept in a cast for a total time of 56 days. In the second stage, an arthrodesis of the affected joint was carried out, using a 13‐hole broad 4.5 LCP plate. The limb was then kept in a cast for an additional total time of 56 days. At 70 days after the arthrodesis, the horse was brought in for a final check‐up, and only a mechanical lameness remained at that time. No significant complications occurred. Previous case reports on the treatment of metatarso‐/metacarpophalangeal luxations include neither cases as severe as the one presented here nor treatment by fetlock arthrodesis. This case illustrates that horses with a complicated, open luxation of the fetlock can be salvaged for breeding purposes.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of a severely contaminated open metatarsophalangeal joint luxation by arthrodesis

Haspeslagh

Schauvliege

Martens

2021

Equine Veterinary Education

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“…Instability associated with implant infection has historically been associated with a guarded prognosis for fracture healing and complete recovery (Goodrich, 2020;Richardson, 2020). contributed to data collection.…”

Section: Con Clus I On S and Outlookmentioning

confidence: 99%

“…implant infection, bacteria produce a biofilm that is very difficult to penetrate for the immune system or antimicrobial agents (Borriello et al, 2004;Stoodley et al, 2005). Recent reports showed that despite local and systemic antimicrobial therapy, wound debridement and removal of infected implants are essential for the elimination of the infection and prevention of further damage to the surrounding tissues (Donati et al, 2021;Goodrich, 2020;Nunamaker, 2020).…”

mentioning

confidence: 99%

“…However, if the fracture has not healed sufficiently at the time of infection, removal of the implants can result in a high risk of instability, refracture and delayed-or non-union (Goodrich, 2020;Ruggles, 2020). In these cases, alternative methods for stabilisation, such as a transfixation pin casting or implant replacement may be required (Ortved & Richardson, 2021).…”

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confidence: 99%

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Alternative approach for fracture fixation following implant infection in a Salter‐Harris type‐II fracture of the proximal phalanx in a Warmblood foal

Kalinovskiy

Ehrle

Müller

et al. 2023

Equine Veterinary Education

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SummaryA 2‐day‐old female Warmblood foal (70 kg) presented with a closed, displaced Salter‐Harris type‐II fracture of the proximal physis of the left hind first phalanx. The fracture was repaired with four 4.5 mm cortical screws and a wire in a figure‐of‐8 pattern applied on the lateral and medial aspect of the phalanx, respectively. A 4.5 mm cortical screw was additionally inserted in lag‐fashion to engage the lateral metaphyseal spike. Three days postoperatively, medial and proximal displacement of the distal fracture fragment and implant infection were apparent and revision surgery was performed. Previous implants were removed and two 4.5 mm transphyseal cortical lag‐screws were placed in proximolateral–distomedial and dorsoproximal–plantarodistal direction across the physis and the fracture line. Postoperatively, the fracture healed rapidly and the implants were removed 6 weeks later. Nineteen months after implant removal, the horse did not show any sign of lameness, despite a shortening of the proximal phalanx compared to the contralateral limb. In cases of postoperative implant instability and infection, implant removal often becomes necessary. However, new implants cannot be placed safely in the previous location. To avoid this problem, this report describes an alternative approach for screw positioning in case of previous implant infection in a Salter‐Harris type‐II fracture of the proximal physis of the first phalanx.

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“…This leads to infiltration of WBCs at the site of infection which attacks the invading bacteria via phagocytosis or secretion of lytic enzymes thereby resulting in the formation of pus and further spread through bone blood vessels. This leads to blockage of proper blood flow and thereby tissue damage in the infected site of the bone (Goodrich, 2019). Cystic fibrosis is one of the most studied biofilm-associated infections which primarily affects the respiratory and the digestive system and is characterized by the generation of viscous mucus and chronic infections (Ciofu et al, 2015).…”

Section: Non-device Associated Infectionsmentioning

confidence: 99%

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

Das

Ghosh

Nayak

2021

Front. Nanotechnol.

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Biofilm is the self-synthesized, mucus-like extracellular polymeric matrix that acts as a key virulence factor in various pathogenic microorganisms, thereby posing a serious threat to human health. It has been estimated that around 80% of hospital-acquired infections are associated with biofilms which are found to be present on both biotic and abiotic surfaces. Antibiotics, the current mainstream treatment strategy for biofilms are often found to be futile in the eradication of these complex structures, and to date, there is no effective therapeutic strategy established against biofilm infections. In this regard, nanotechnology can provide a potential platform for the alleviation of this problem owing to its unique size-dependent properties. Accordingly, various novel strategies are being developed for the synthesis of different types of nanoparticles. Bio-nanotechnology is a division of nanotechnology which is gaining significant attention due to its ability to synthesize nanoparticles of various compositions and sizes using biotic sources. It utilizes the rich biodiversity of various biological components which are biocompatible for the synthesis of nanoparticles. Additionally, the biogenic nanoparticles are eco-friendly, cost-effective, and relatively less toxic when compared to chemically or physically synthesized alternatives. Biogenic synthesis of nanoparticles is a bottom-top methodology in which the nanoparticles are formed due to the presence of biological components (plant extract and microbial enzymes) which act as stabilizing and reducing agents. These biosynthesized nanoparticles exhibit anti-biofilm activity via various mechanisms such as ROS production, inhibiting quorum sensing, inhibiting EPS production, etc. This review will provide an insight into the application of various biogenic sources for nanoparticle synthesis. Furthermore, we have highlighted the potential of phytosynthesized nanoparticles as a promising antibiofilm agent as well as elucidated their antibacterial and antibiofilm mechanism.

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Osteomyelitis

Cited by 3 publications

References 86 publications

Successful treatment of a severely contaminated open metatarsophalangeal joint luxation by arthrodesis

Successful treatment of a severely contaminated open metatarsophalangeal joint luxation by arthrodesis

Alternative approach for fracture fixation following implant infection in a Salter‐Harris type‐II fracture of the proximal phalanx in a Warmblood foal

Phyto-fabricated Nanoparticles and Their Anti-biofilm Activity: Progress and Current Status

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