Osteomielitis crónica multifocal recurrente

Martín, Segundo; Hofheinz, Sylvia Belda; Conejo, Pablo Rojo; Pinedo, B Losada; Amador, JT Ramos; Pollán, J Clemente; Ruiz–Contreras, Jesús

doi:10.1157/13075550

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Other options described are corticoids, interferon, calcitonin, azithromycin, sulfasalazine and bisphosphonates. In severe cases, tumor necrosis factor (TNF) blockers may be used 3,17 . The prognosis of the disease is relatively benign, although most cases may be resolved spontaneously, relapses may occur after months or even years, lasting for an average of 5 years, with asymptomatic intervals in between.…”

Section: Discussionmentioning

confidence: 99%

“…Higher rates of remission have been seen in patients who have received an aggressive treatment at an early stage, improving the natural history in those in which it may become recurrent. It has been recently proposed that this condition may persist into adulthood, with possible long-term effects, in addition to complications such as infections, early epiphyseal fusion leading to height compromise, bone deformities, backbone kyphosis and persistence of bone sclerosis that have been reported in a minority of patients 1,2,3,14 .…”

Section: Discussionmentioning

confidence: 99%

“…From a clinical point of view it mainly manifests with inflammatory symptoms such as bone pain, paresthesias, erythema, edema and local functional limitation, and usually targets the metaphysis of long bones, mainly the femur and the tibia, as well as other places such as the clavicle, mandible, sternum and vertebrae 3,4 . In some cases, fever may occur, usually followed by skin disorders 1,2 .…”

Section: Introductionmentioning

confidence: 99%

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Osteomielitis crónica multifocal recurrente en paciente pediátrico, reporte de caso

Muñoz

Correa

Samudio

et al. 2017

Rev. chil. pediatr.

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Introduction: Chronic recurrent multifocal osteomyelitis (CRMO) is a very rare disease, of unknown origin that affects primarily the metaphysis of long bones. It is characterized by an insidious onset of symptoms and multiple remissions. The chronicity of symptoms, the diagnostic imaging and the lack of response to first line antibiotic treatment, should be helpful for diagnostic. Objective: Present a clinical case, based on clinical, laboratory, radiologic imaging and histopathological results, that ultimately led to the diagnostic of CRMO. Case report: 9 year old, female patient, with one month of bilateral knee and left ankle arthralgia. Bone Gammagraphy and full body MRI, showed multifocal bone inflammation. These findings led to a biopsy, that turned negative for malignancy and infection. Given all the information available from the laboratory test results, radiologic imaging and histopathological findings, CRMO diagnosis was made. NSAID treatment was order, with good results. Conclusions: CRMO is a rare disease that even to date and with cutting edge technology, still represents a diagnostic challenge that primarily relies on a high level of suspicion, for a timely and correct treatment.

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Section: Discussionmentioning

confidence: 99%