Osteomalacia Following Gastric Surgery

Im, Baird; Oleesky, S.

doi:10.1016/s0016-5085(19)35769-5

Cited by 55 publications

(13 citation statements)

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“…The deficiency of vitamin D in steatorrhea can be explained by the impaired inteytinal absorption (29), but inadequate dietary intake of vitamin D is also a weighty reason for postgastrectomy osteomalacia (13). Bone disease manifests itself more than 5 years after the gastric resection (12), but it has been suggested that there is no correlation between the time interval and the severity of mineral disturbances (4,7,25,26,(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

“…In a study of Polya-operated duodenal ulcer patients a significant decrease in bone mineral content was shown (38). The Polya-type operation disturbs the digestive process more severely than the Billroth-I-type operation, and bone complications are probably also commoner and severer after Polya gastrectomy (4,7,8,13,(28)(29)(30)39).…”

Section: Discussionmentioning

confidence: 99%

“…A deficiency of vitamin D has b e e n proved t o be t h e main factor in t h e pathogenesis of postgastrect o m y osteomalacia (10, 13), a n d vitamin D ther-apy h a s b e e n s h o w n to i m p r o v e osteomalacic changes (7,10,12,(14)(15)(16). Fractures d u e t o b o n e fragility are more frequent in postgastrectomy patients t h a n in age-matched controls (8,17).…”

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confidence: 99%

“…Hoikku er (11 resection according to Billroth I with (34 patients) or without (8 patients) selective gastric vagotomy were included in the study. The median time from the operation was 6 years (range, [5][6][7]. The criterion for the selection of the patients was that they had not had, before or after the operation, any disease of medication except their ulcer disease or a postgastrectomy status that might disturb bone mineral metabolism (18).…”

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confidence: 99%

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The Effect of Partial Gastrectomy on Bone Mineral Metabolism

Hoikka

Alhava

Savolainen

et al. 1982

Scandinavian Journal of Gastroenterology

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The occurrence of postgastrectomy bone disease was studied in 42 patients who had been subjected to gastric surgery for duodenal or gastric ulceration 5-7 years earlier. Hypocalcemia, hypophosphatemia, and an increase in serum alkaline phosphatase were infrequent. No difference was observed in S-25OHD between the patients and controls, but S-24,25(OH)2D was higher in the patients. The bone mineral density (BMD) values showed no statistically significant difference between the patients and controls before or after the operation. There was a slight fall in BMD values during the follow-up period, but the decrease was similar in the patients and controls and was not statistically significant. The histomorphometric analysis revealed a greater amount of trabecular bone and osteoid in the patients. The means of the osteoid variables were well within normal limits, but a very slight increase in osteoid volume was observed in 4 of the 35 patients. It is concluded that a partial gastrectomy and vagotomy had not caused significant disturbances in bone mineral metabolism. The vitamin D status of the patients was good owing to the adequate dietary regimens that had been given to the patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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The Effect of Partial Gastrectomy on Bone Mineral Metabolism

Hoikka

Alhava

Savolainen

et al. 1982

Scandinavian Journal of Gastroenterology

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“…Knochenverä nderungen nach Gastrektomie sind seit langem bekannt [4,22,54]. Bereits in den 60 er Jahren wurde die Magenresektion als Risikofaktor fü r eine Fraktur identifiziert [2].…”

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Calcium- und Knochenstoffwechsel nach Gastrektomie

Zittel

Maier

Starlinger

et al. 1997

Chirurg

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Disturbances in calcium and bone metabolism after gastrectomy have long been recognized. It has been suggested that due to impaired calcium absorption after gastrectomy, serum calcium is decreased, being counter-regulated by parathyroid hormone release and 1,25-(OH)2-vitamin D formation. Both parathyroid hormone and 1,25-(OH)2-vitamin D are known to release calcium from bone, resulting in bone mass loss and increased fracture risk in some of the gastrectomized patients. No therapy is currently generally agreed on, although supplementation of vitamin D and calcium has been suggested repeatedly. A review on the current understanding of calcium and bone metabolism after gastrectomy is given.

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Effects of upper gastro-intestinal surgery on blood formation and bone metabolism

Williams¹

1964

British Journal of Surgery

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Osteomalacia Following Gastric Surgery

Cited by 55 publications

References 2 publications

The Effect of Partial Gastrectomy on Bone Mineral Metabolism

The Effect of Partial Gastrectomy on Bone Mineral Metabolism

Calcium- und Knochenstoffwechsel nach Gastrektomie

Effects of upper gastro-intestinal surgery on blood formation and bone metabolism

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