Osteomalacia due to a Bladder Reconstruction Performed 35 Years Previously

Hirukawa, Misa; Funakoshi, Hiraku; Tsukamoto, Tomoko; Ohira, Yoshiyuki; Ikusaka, Masatomi

doi:10.2169/internalmedicine.51.7980

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…The onset of symptoms after urinary diversion reportedly takes 2-11 years (9-12), our patient although had a long history of musculoskeletal pain, the diagnosis of metabolic bone disease was 31 years after the operation. Hirukawa et al has reported a patient with osteomalacia due to bladder reconstruction performed 35 years previously, the longest postoperative interval before the diagnosis and the highest chloride level in the literature (13). Our patient had moderately increased chloride level although there was a very long postoperative period at diagnosis.…”

Section: Discussionmentioning

confidence: 50%

Osteomalacia as a Result of Urinary Diversion

et al. 2017

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A 54 years old man, who had undergone a cystectomy and urinary diversion surgery 31 years previously, complained of progressive generalized bone pain, muscle weakness and walking abnormality for six months. Laboratory investigations revealed elevated alkaline phosphatase, high serum chloride level and metabolic acidosis. Osteomalacia was suspected due to clinical and laboratory findings. Osteomalacia due to hyperchloremic metabolic acidosis is a complication of urinary diversion. Regular monitoring of pH, chloride, bicarbonate, and calcium-phosphorus metabolism is therefore essential for early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 50%

Osteomalacia as a Result of Urinary Diversion

et al. 2017

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“…La osteomalacia puede aparecer entre 2 y 4 años después de la intervención, si bien hay casos descritos hasta 35 años después 20,23 . Los pacientes con osteomalacia tras derivación urinaria mediante ileon o colon suelen tener niveles séricos elevados de Cl − y déficit de HCO3 − .…”

Section: Osteomalacia Y Enfermedad óSea Asociadas a Los Trastornos Hiunclassified

Complicaciones metabólicas y óseas de las derivaciones urinarias

Megías

Delgado

2015

Endocrinología y Nutrición

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“…Hypophosphatemia—a condition in which osteomalacia is caused by impaired phosphorus absorption and reabsorption—is known to be caused by tumour-induced osteomalacia (TIO) and renal tubular acidosis 5 6. The FGF23 marker is useful for the diagnosis of TIO, as its levels are high in TIO patients and rapidly decrease after resection of the tumours responsible for the TIO 5.…”

Section: Differential Diagnosismentioning

confidence: 99%

Vitamin D-deficient osteomalacia due to excessive self-restrictions for atopic dermatitis

Shikino¹,

Ikusaka

Yamashita

2014

BMJ Case Reports

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SUMMARYA 34-year-old Japanese woman presented with a 2-year history of generalised bone pain, muscle weakness and gait disturbance. The patient had been following a restricted diet (without fish or dairy products) and avoiding ultraviolet exposure for 8 years to manage her worsening atopic dermatitis. Physical examination revealed generalised bone tenderness and bilateral symmetric proximal muscle weakness. Vitamin Ddeficient osteomalacia was diagnosed based on the laboratory examination findings, which indicated high serum alkaline phosphatase, high intact parathyroid hormone, and low 25-hydroxyvitamin D levels. Her symptoms improved after oral active vitamin D and calcium administration. To the best our knowledge, this case is the first report of vitamin D-deficient osteomalacia in an adult patient due to excessive dietary restriction for managing atopic dermatitis. We emphasise the importance of increasing awareness of vitamin D deficiency as a risk factor for the development of osteomalacia, and caution against excessive avoidance of sun exposure and dietary restriction. BACKGROUND

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Osteomalacia due to a Bladder Reconstruction Performed 35 Years Previously

Cited by 4 publications

References 4 publications

Osteomalacia as a Result of Urinary Diversion

Osteomalacia as a Result of Urinary Diversion

Complicaciones metabólicas y óseas de las derivaciones urinarias

Vitamin D-deficient osteomalacia due to excessive self-restrictions for atopic dermatitis

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