Osteomalacia and Rickets

Treager, Christopher; Isales, Carlos M.

doi:10.1007/978-3-319-52567-9_153

Cited by 1 publication

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References 17 publications

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“…An imbalance on the amounts and distribution of the bone matrix components (eg, HA crystals and collagen fibers) can lead to serious pathologic alterations on bone microarchitecture and composition, compromising its mechanical properties. These alterations are commonly associated with increased risk of fracture, as described in several bone pathologies related to impaired mineralization of the bone matrix, such in osteogenesis imperfecta, osteomalacia, and rickets . Moreover, denser bones do not necessarily translate into stronger bones and resistance to fracture .…”

Section: Introductionmentioning

confidence: 99%

The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix

et al. 2020

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Genetic and pharmacological functional studies have provided evidence that the lack of Neuropeptide Y‐Y1 receptor (Y1R) signaling pathway induces a high bone mass phenotype in mice. However, clinical observations have shown that drug or genetic mediated improvement of bone mass might be associated to alterations to bone extracellular matrix (ECM) properties, leading to bone fragility. Hence, in this study we propose to characterize the physical, chemical and biomechanical properties of mature bone ECM of germline NPY‐Y1R knockout (Y1R−/−) mice, and compare to their wild‐type (WT) littermates. Our results demonstrated that the high bone mass phenotype observed in Y1R−/− mice involves alterations in Y1R−/− bone ECM ultrastructure, as a result of accelerated deposition of organic and mineral fractions. In addition, Y1R−/− bone ECM displays enhanced matrix maturation characterized by greater number of mature/highly packed collagen fibers without pathological accumulation of immature/mature collagen crosslinks nor compromise of mineral crystallinity. These unique features of Y1R−/− bone ECM improved the biochemical properties of Y1R−/− bones, reflected by mechanically robust bones with diminished propensity to fracture, contributing to greater bone strength. These findings support the future usage of drugs targeting Y1R signaling as a promising therapeutic strategy to treat bone loss‐related pathologies.

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Section: Introductionmentioning

confidence: 99%

The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix

et al. 2020

View full text Add to dashboard Cite

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Osteomalacia and Rickets

Cited by 1 publication

References 17 publications

The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix

The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix

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Osteomalacia and Rickets

Cited by 1 publication

References 17 publications

The lack of neuropeptide Y‐Y 1 receptor signaling modulates the chemical and mechanical properties of bone matrix

The lack of neuropeptide Y‐Y 1 receptor signaling modulates the chemical and mechanical properties of bone matrix

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The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix

The lack of neuropeptide Y‐Y ₁ receptor signaling modulates the chemical and mechanical properties of bone matrix