Osteolytic bone lesions – A rare presentation of AML M6.

Abstract

Acute myeloid leukemia (AML) M6 is a rare form of AML accounting for < 5 % of all AML. Extramedullary involvement is very rarely seen in this entity. Skeletal lesion has not been described in AML M6 before. We discuss the case of a 17 year old boy with AML M6, who presented with osteolytic lesion of right humerus. He was treated with induction and consolidation chemotherapy. The present case is the first report in literature of AML M6 presenting with skeletal lesions.

Diffuse Loss of Vertebral Body Height and Marrow Changes in a 4-Year-Old with Acute Lymphoblastic Leukemia

“…6 These radiographic findings in patients with acute leukemia include osteopenia, radiolucent metaphyseal bands, periosteal reaction, osteolysis, osteosclerosis, mixed lesions (lytic and sclerotic), permeating pattern, pathological fractures, and avascular osteonecrosis. [5][6][7] Differential diagnosis of these findings includes many chronic and systemic disorders, such as rheumatoid arthritis, rheumatic fever, septic arthritis, osteomyelitis, transient synovitis, sickle cell anemia, scurvy, and dermatomyositis. 7 The correlation of osseous radiologic findings, nonosseous radiologic findings, and laboratory results is necessary to make the proper diagnosis of acute leukemia.…”

“…[5][6][7] Differential diagnosis of these findings includes many chronic and systemic disorders, such as rheumatoid arthritis, rheumatic fever, septic arthritis, osteomyelitis, transient synovitis, sickle cell anemia, scurvy, and dermatomyositis. 7 The correlation of osseous radiologic findings, nonosseous radiologic findings, and laboratory results is necessary to make the proper diagnosis of acute leukemia. 6 Imaging may precede the medical workup; however, laboratory values such as blood counts, metabolic profile, vitamin levels, electrolyte levels, hormone levels, autoimmune markers, and inflammatory markers may aid in putting imaging findings into proper clinical context.…”

In VivoMurine Model of Leukemia Cell-Induced Spinal Bone Destruction

“…Osteoarticular changes may occur in up to 23% of cases of acute lymphoblastic leukemia (ALL) and even more frequently in AML [9]. Previously reported clinical cases of destructive osteolytic bone lesions were shown to occur in the setting of extramedullary blast crisis of CML [10], granulocytic leukemia [11], or AML [12]. Bone destruction was attributed to the invasion of leukemic myeloblasts.…”