Osteological, multi-isotope and proteomic analysis of poorly-preserved human remains from a Dutch East India Company burial ground in South Africa
Judyta Olszewski,
Rachael A. Hall,
Lisette M. Kootker
et al.
Abstract:Skeletal remains discovered in Simon’s Town, South Africa, were hypothesised as being associated with a former Dutch East India Company (VOC) hospital. We report a novel combined osteological and biochemical approach to these poorly-preserved remains. A combined strontium (87Sr/86Sr), oxygen (δ18OVPDB) and carbon (δ13CVPDB) isotope analysis informed possible childhood origins and diet, while sex-specific amelogenin enamel peptides revealed biological sex. Osteological analyses presented evidence of residual ri… Show more
“…Similarly, Mays et al [335] identified the sex of highly degraded skeletal remains dated 1 st century BCE overcoming the limitation posed by high-throughput DNA sequencing, that failed as no aDNA survived in such remains. Olszewski et al [336] recently conducted proteomic analyses on human remains from a Dutch East India Company burial ground in South Africa and managed confirm the biological sex of the remains from these poorly preserved samples.…”
Section: Proteomics For Personal Identificationmentioning
Recent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high‐throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biomedicine and cancer biology, its full potential in forensic sciences remains only partially explored. In this review, we have presented a comprehensive overview of state‐of‐the‐art analytical platforms employed in omics research, with specific emphasis on their application in the forensic field for the identification of the cadaver and the cause of death. Moreover, we have conducted a critical analysis of the computational integration of omics approaches, and highlighted the latest advancements in employing multi‐omics techniques for forensic investigations.
“…Similarly, Mays et al [335] identified the sex of highly degraded skeletal remains dated 1 st century BCE overcoming the limitation posed by high-throughput DNA sequencing, that failed as no aDNA survived in such remains. Olszewski et al [336] recently conducted proteomic analyses on human remains from a Dutch East India Company burial ground in South Africa and managed confirm the biological sex of the remains from these poorly preserved samples.…”
Section: Proteomics For Personal Identificationmentioning
Recent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high‐throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biomedicine and cancer biology, its full potential in forensic sciences remains only partially explored. In this review, we have presented a comprehensive overview of state‐of‐the‐art analytical platforms employed in omics research, with specific emphasis on their application in the forensic field for the identification of the cadaver and the cause of death. Moreover, we have conducted a critical analysis of the computational integration of omics approaches, and highlighted the latest advancements in employing multi‐omics techniques for forensic investigations.
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