Osteolipoma: a rare tumor in the oral cavity

Abstract

Osteolipoma is a rarely reported histologic variant of lipoma that exhibits bone formation. To the best of our knowledge, only 13 well-documented case reports of osteolipoma in the oral cavity have been published in the English literature. This study presents the clinical, radiographic, and histologic features of an osteolipoma in the oral cavity and reviews the pertinent literature. The patient was a 29-year-old female, who presented with an 8-month history of a painless, progressively enlarging, well-defined, movable submucosal mass in the left posterior buccal mucosa. The lesion had a hard consistency. Imaging findings revealed a spherical radiopacity with an irregular trabecular pattern. The lesion was excised and the diagnosis of osteolipoma was established. No recurrence was observed after a 5-year follow-up.

Stem Cells Derived from Lipoma and Adipose Tissue—Similar Mesenchymal Phenotype but Different Differentiation Capacity Governed by Distinct Molecular Signature

“…No other markers or details on osteogenic differentiation of these cells were reported. However, there are numerous reports on lipoma tissue ossification observed in different parts of the body [8,16,18,19,60,61,62,63] and this phenomenon could be explained by the existence of stem cells in lipoma tissue that may differentiate into osteoblasts and chondrocytes.…”

“…Lipomas are benign tumors of adipose tissue and represent one of the most common soft tissue neoplasms of mesenchymal origin [8,9]. Lipomas can be solitary, multiple generalized lipomatosis and multiple symmetric, usually slowly growing, diffused or encapsulated, can vary in size and shape and show great heterogeneity in cell populations presented within the tissue [10,11].…”

"Osteolipoma of buccal mucosa: Case report and literature review"

“…Only one case reported by Amaral MB et al ( 6 ) had radiographic findings similar to our case i.e., multiple dense homogenous radio-opaque structures. Other cases had radiographic presentation of a mass with area of calcification ( 7 ), patchy areas of radio-opacity ( 8 ); irregular area of radio-opacity, mixed hypodense and hyperdense areas on CT; round area of radio-opacity with irregular pattern of trabeculae ( 9 ). Multiple calcifications of oral soft tissues is commonly seen in vascular lesions (phleboliths) and oral cysticercosis.…”

Investigation of stemness and multipotency of equine adipose-derived mesenchymal stem cells (ASCs) from different fat sources in comparison with lipoma

“…Lipomas (LPs) have been reported as an alternative to SC fat for ASC isolation [20]. Lipomas are benign tumors of adipose tissue and represent one of the most common soft tissue neoplasms of mesenchymal origin in humans [21, 22]. In man, lipomas can occur either as localized nodules or in the form of generalized lipomatosis.…”