Osteokines and Bone Markers at Rest and following Plyometric Exercise in Pre- and Postmenopausal Women

Nelson, Katlynne; Kouvelioti, Rozalia; Theocharidis, Alexandros; Falk, Bareket; Tiidus, Peter M.; Klentrou, Panagiota

doi:10.1155/2020/7917309

Cited by 12 publications

(14 citation statements)

References 39 publications

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“…Preferably, both sexes should have been evaluated also in the elderly group, but we chose to prioritize men in an attempt to undermine the estrogen component related to aging. In the context of skeletal health, it could be argued that elderly women would be more relevant, although previous studies suggest that comparable results as in the present study can be expected ( 33 , 65 ).…”

Section: Study Strengths and Limitationssupporting

confidence: 66%

“…In continuation of this, a more recent study reported beneficial effects of plyometric exercise on the P1NP/CTX-1 ratio in premenopausal women, an effect that was blunted in postmenopausal women ( 33 ). The latter study reported the effect of BTMs as a formation/resorption ratio, using P1NP and CTX-1 ( 33 ). In the current study, we present P1NP/CTX-1 ratio, as part of a strategy to overcome the existing discrepancy between studies, as also suggested and used in several other reports ( 46 – 48 ).…”

Section: Discussionmentioning

confidence: 73%

“…These results are partly in line with a study by Maïmoun et al, who found no significant change in CTX-1 in elderly participants after a maximal incremental exercise test (45); however, both elderly men and women were included, and P1NP was not measured in this study. In continuation of this, a more recent study reported beneficial effects of plyometric exercise on the P1NP/CTX-1 ratio in premenopausal women, an effect that was blunted in postmenopausal women (33). The latter study reported the effect of BTMs as a formation/ resorption ratio, using P1NP and CTX-1 (33).…”

Section: Age and Sex Differences In Training-induced Changes In Serum...mentioning

confidence: 77%

“…A systematic review of BTMs in subjects with osteoporosis revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers (32). Whereas some studies have reported beneficial acute effects of exercise on BTMs (17,22,33), a direct comparison of heavy resistance training and aerobic running exercise has not yet been performed under strictly controlled conditions. Hack squat ST and treadmill HIIT are two well-studied training interventions that are highly relevant in the context of musculoskeletal and cardiometabolic health (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

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ContextExercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain.ObjectiveTo assess the acute effects of two different exercise modes on BTMs and related markers in young adults of both sexes and elderly men.Design, Setting, ParticipantsThis was a three-group crossover within-subjects design study with a total of 53 participants—19 young women (aged 22–30), 20 young men (aged 21–30 years), and 14 elderly men (aged 63–74 years)—performing two different exercise sessions [strength training (ST) and high-intensity interval training (HIIT)] separated by 2 weeks, in a supervised laboratory setting.Main Outcome MeasuresPlasma volume-corrected serum measurements of the BTMs C-terminal telopeptide of type 1 collagen (CTX-I) and procollagen of type 1 N-terminal propeptide (P1NP), total osteocalcin (OC), sclerostin, and lipocalin-2 (LCN2) at baseline, immediately after, and 3 and 24 h after each of the two exercise modes were performed.Results and ConclusionAnalyses revealed sex- and age-dependent differences in BTMs and related bone markers at baseline and time-, sex-, and age-dependent differences in response to exercise. No differences between exercise modes were observed for BTM response except for sclerostin in young men and LCN2 in elderly men. An acute, transient, and uniform increase in P1NP/CTX-1 ratio was found in young participants, demonstrating that beneficial skeletal effects on bone metabolism can be attained through both aerobic endurance and resistance exercise, although this effect seems to be attenuated with age. The acute effects of exercise on bone-related biomarkers were generally blunted after 24 h, suggesting that persistent alterations following prolonged exercise interventions should be assessed at later time points.

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Section: Study Strengths and Limitationssupporting

confidence: 66%

Section: Discussionmentioning

confidence: 73%

Section: Age and Sex Differences In Training-induced Changes In Serum...mentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

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“…Sensitivity of the method for individual measurements was 6.225 ng/ml for PICP, with a coefficient of variation of 0–12%, for ICTP 6.5–7.2%. The results were interpreted by adopting the reference values of 30–300 ng/ml for PICP and 2.1–5.6 ug/l for ICTP [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

The effect of the menstrual cycle on collagen metabolism, growth hormones and strength in young physically active women

Iwańska¹,

Kęska²,

Dadura³

et al. 2021

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This study aimed to investigate the effect of the menstrual cycle on strength, functioning of the GH/IGF-1 axis and collagen metabolism in physically active women. Twenty-four physically active and eumenorrheic women volunteered to participate in the study (body mass 60.3 ± 9.18 kg, age 21.8 ± 0.92 years). Blood samples were obtained between the 5th and 8th days (the follicular phase) and between the 19th and 22th days (the luteal phase) of the menstrual cycle to determine sex steroid concentrations (follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), oestradiol (E2) and progesterone (P)). Also insulin-like growth factor 1 (IGF-1) and collagen metabolism markers (synthesis (PICP) and breakdown (ICTP)) and maximum voluntary contraction (MVC) were measured. MVC was higher in the luteal phase 164.1 ± 34.77 [N m] (F(1.23) = 4.59; p = 0.043). The recorded collagen synthesis marker (PICP = 296.4 ± 35.61 [ng/ml]) was at the upper level of the reference range (30–300), with an insignificant decrease in the luteal phase (Z = 1.612; p = 0.107) and a significant increase in oestradiol concentration (Z = 4.286; p = 0.0001). The marker of collagen breakdown (ICTP = 4.16 ± 0.68 [μg/l]) was reduced by 6.8% in the same phase (Z = 1.764; p = 0.137). The variability of physical abilities (MVC) during the menstrual cycle showed that menstrual status should be taken into account in determination of the training loads. Increasing the load in the luteal phase seems to be favoured by a beneficial change in collagen metabolism (lower synthesis decrease, lower breakdown increase) observed in physically active women.

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Knochengewebe

Laube

2023

Bewegungsmangel

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Osteokines and Bone Markers at Rest and following Plyometric Exercise in Pre- and Postmenopausal Women

Cited by 12 publications

References 39 publications

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

The effect of the menstrual cycle on collagen metabolism, growth hormones and strength in young physically active women

Knochengewebe

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