Osteointegration of implants in radiated bone with and without adjunctive hyperbaric oxygen

Larsen, Peter E.; Stronczek, Michael J.; Beck, F. Michael; Rohrer, Michael D.

doi:10.1016/s0278-2391(10)80176-4

Cited by 66 publications

(21 citation statements)

References 13 publications

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“…Moreover, HBO therapy increases the amount of force necessary to unscrew integrated titanium implants in irradiated bone, which suggests that promoted integration has occurred. Larsen et al showed a difference of 13.9% in mean percent of integration after 4 months in irradiated versus nonirradiated animals. This difference dropped to 6.38% when animals received HBO before and after implantation.…”

Section: Discussionmentioning

confidence: 97%

Dental implants in irradiated versus nonirradiated patients: A meta‐analysis

2015

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The purpose of the present meta-analysis was to test the null hypothesis of no difference in dental implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants and being previously irradiated in the head and neck region versus nonirradiated patients against the alternative hypothesis of a difference. The study suggests that irradiation negatively affects the survival of implants, as well as the difference in implant location (maxilla vs mandible), but there is no statistically significant difference in survival when implants are inserted before or after 12 months after radiotherapy. The study failed to support the effectiveness of hyperbaric oxygen therapy in irradiated patients. It was observed that there was a tendency of lower survival rates of implants inserted in the patients submitted to higher irradiation doses. The results should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies.

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Section: Discussionmentioning

confidence: 97%

Dental implants in irradiated versus nonirradiated patients: A meta‐analysis

2015

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“…Osteoradionecrosis was not observed in this study. The risk of osteoradionecrosis has been estimated at 4%, 10,15,18,19 with the mandible as the most susceptible location 10 . Because of the diffuse blood supply, the risk for necrosis in the maxilla is negligible in comparison 5 …”

Section: Discussionmentioning

confidence: 99%

Long‐Term Results of Endosteal Implants Following Radical Oral Cancer Surgery with and without Adjuvant Radiation Therapy

Linsen

Martini

Stark

2012

Clin Implant Dent Rel Res

101

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Implant survival is not significantly influenced by radiation therapy, grafts (bone and/or soft tissue), or location (maxilla or mandible). However, implants placed in irradiated bone exhibit a higher failure rate during the healing period than those placed in non-irradiated bone. No superstructure was particularly favorable. Osseointegrated implants can be used successfully in patients with prior history of ablative surgery with and without additional radiation therapy.

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“…Especially implants placed into an irradiated tissue bed bear the risk of consecutive higher failure rates [41][42][43][44] or even infected osteoradionecrosis of the jaw, resulting in critical or even dissuading views considering these implant indications [45,46] . On the other hand, many authors underline the benefit of dental implants placed into augmented and/or irradiated tissues but stress mandatory treatment principles [22,33,34,[47][48][49][50][51][52] . Up to now, reports of implants in tumor patients included all types of restoration.…”

Section: Discussionmentioning

confidence: 99%

Functional Rehabilitation of Mandibular Continuity Defects Using Autologous Bone and Dental Implants – Prognostic Value of Bone Origin, Radiation Therapy and Implant Dimensions

Klein

Grötz²,

Wegener³

et al. 2009

Eur Surg Res

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Aim: The aim of this retrospective study was to investigate prognostic parameters for the rehabilitation of mandibular continuity defects with free autologous bone and dental implants for patients after intraoral squamous cell carcinoma. Methods: Following potential prognostic factors for implant survival were analyzed: bony bed (local bone versus augmented iliac crest bone), radiation dose (no radiation, <50 Gy, ≥50 Gy) and implant dimensions. Kaplan-Meier survival estimates of the inserted implants were performed. Results: After 5 years, the cumulative survival rate of all investigated implants was 82.6%. Dental implantation into augmented bone resulted in a significantly lower survival rate (78.4%), compared to original local bone (92.8%). Modifications of implant dimensions as well as radiation therapy showed no significant impact on implant survival. Conclusion: For the investigated compromised collective, our results reveal a satisfactory long-term survival rate of dental implants even in augmented bone and underline the value of dental implantation for the functional rehabilitation of cancer patients.

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Osteointegration of implants in radiated bone with and without adjunctive hyperbaric oxygen

Cited by 66 publications

References 13 publications

Dental implants in irradiated versus nonirradiated patients: A meta‐analysis

Dental implants in irradiated versus nonirradiated patients: A meta‐analysis

Long‐Term Results of Endosteal Implants Following Radical Oral Cancer Surgery with and without Adjuvant Radiation Therapy

Functional Rehabilitation of Mandibular Continuity Defects Using Autologous Bone and Dental Implants – Prognostic Value of Bone Origin, Radiation Therapy and Implant Dimensions

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