Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

Plantz, Mark A.; Minardi, Silvia; Lyons, Joseph G.; Greene, Allison C.; Ellenbogen, David J.; Hallman, Mitchell; Yamaguchi, Jonathan T.; Jeong, Soyeon; Yun, Chawon; Jakus, Adam E.; Blank, Kenneth R.; Havey, Robert M.; Muriuki, Muturi; Patwardhan, Avinash G.; Shah, Ramille N.; Hsu, Wellington K.; Stock, Stuart R.; Hsu, Erin L.

doi:10.1016/j.actbio.2021.03.060

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…In addition to the use of 3D printed anatomical models for preoperative planning and personalized guiding templates to improve the safety and success rate of pedicle screw placement, 3D printed customized implants and 3D bio-printing have also emerged [ 8 ]. Some researchers have found that titanium-alloy was designed with unique architectures based on 3D printing such as a highly interconnected and specific porous structure that mimics the architecture of trabecular bone, which can achieve better results of bone fusion [ 9 , 10 ]. In addition, the combination of 3D printing with other technologies, such as finite element method, has also emerged to help surgeons better choose alternatives when a common screw-setting solution was difficult to achieve [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Application of Image-Fusion 3D Printing Model in Total En Bloc Spondylectomy for Spinal Malignant Tumors

Wang

Xiang

Tian

et al. 2022

Journal of Healthcare Engineering

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Purpose. To examine the effects of 3D printing model in total en bloc spondylectomy (TES). Methods. We performed a retrospective chart review of 41 cases of spinal tumors at our institution between 2017 and 2020, in which TES was applied. There were 19 cases with 3D printing model and 22 cases without 3D printing model. Operation time, intraoperative blood loss, excision range, complications, VAS, and ASIA grades were recorded. Statistical methods were used to analyze the data. KaplanMeier survival curve was made to evaluate the survival. Result. There were significant differences in intraoperative blood loss between the two groups. The rate of R0 resection and tumor envelope preservation were higher in 3D group than that in non-3D group. In 3D group, the complications included surgical site infection (5.2%) and cerebrospinal fluid leak (15.7%). In non-3D group, the complications included cerebrospinal fluid leak (27.3%) and nerve root injury (13.6%). The pain and neurological dysfunction were significantly relieved before and after surgery in 3D group. However, the neurological relief in non-3D group patients was not complete. The VAS scores of non-3D group at 6 months after surgery were much higher than that of 3D group. Conclusion. The application of 3D printing model not only helps surgeons observe the morphology, invasion range, and anatomic relationship of the tumor preoperatively, but also assists surgeons to judge, locate, and separate the tumor intraoperatively. For spinal malignancies, the 3D printing model is worth promoting.

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Section: Discussionmentioning

confidence: 99%

Application of Image-Fusion 3D Printing Model in Total En Bloc Spondylectomy for Spinal Malignant Tumors

Wang

Xiang

Tian

et al. 2022

Journal of Healthcare Engineering

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“…There are several studies following the rationale of having synthetic polymeric support for depositing the natural inks in-between the synthetic filaments (figure 5(a)), providing mechanical support while the matrices undergo reticulation [118,119,242,243]. Other authors mixed PLGA with tissue-specific ECM and HA to act as an ink binder for extrusion printing (figure 5(b)), which demonstrated being a valuable scaffold for spine fusion [239][240][241]. 3D printed PCL was also used to provide different mechanical proprieties to multilayer constructs with human-derived keratin intercalating the PCL layers (figure 5(c)), which demonstrated high dermal regenerative capacity compared with bare PCL controls [147].…”

Section: State-of-the-artmentioning

confidence: 99%

Biomaterials of human source for 3D printing strategies

et al. 2023

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Three-dimensional printing has risen in recent years as a promising approach that fast-tracked the biofabrication of tissue engineering constructs that most resemble utopian tissue/organ replacements for precision medicine. Additionally, by using human-sourced biomaterials engineered towards optimal rheological proprieties of extrudable inks, the best possible scaffolds can be created. These can encompass native structure and function with a low risk of rejection, enhancing overall clinical outcomes; and even be further optimized by engaging in information- and computer-driven design workflows. This paper provides an overview of the current efforts in achieving ink’s necessary rheological and print performance proprieties towards biofabrication from human-derived biomaterials. The most notable step for arranging such characteristics to make biomaterials inks are the employed crosslinking strategies, for which examples are discussed. Lastly, this paper illuminates the state-of-the-art of the most recent literature on already used human-sourced inks; with a final emphasis on future perspectives on the field.

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“…After five test cycles, rhBMP-2-based scaffold recorded a mean stiffness of 2.32 × 10 –2 ± 1.87 × 10 –2 N m/deg compared to the Hap-DBM scaffold which recorded a mean stiffness of 3 × 10 –4 ± 9 × 10 –5 N m/deg. The rhBMP-2 treatment resulted in much greater stabilization relative to treatment with the Hap-DBM scaffolds …”

Section: Flexion Torsion and Tension In Bioscaffoldsmentioning

confidence: 99%

Section: Flexion Torsion and Tension In Bioscaffoldsmentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

Cited by 21 publications

References 39 publications

Application of Image-Fusion 3D Printing Model in Total En Bloc Spondylectomy for Spinal Malignant Tumors

Application of Image-Fusion 3D Printing Model in Total En Bloc Spondylectomy for Spinal Malignant Tumors

Biomaterials of human source for 3D printing strategies

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

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