Osteoinductive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia

Liu, Yuanda; Wang, Jing; Jiang, Ming; Li, Xueyan; Zhang, Qinghao; He, Hongyan

doi:10.1016/j.colsurfb.2022.112450

Cited by 15 publications

(9 citation statements)

References 42 publications

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“…This structure exhibits a network structure open to the surrounding body fluid [ 72 ]. (3) As calcium phosphate is the main inorganic component of human bones, the released ions from either the amorphous or crystalline coating increase the local inorganic ion concentration and consequently enhance new bone formation adjacent to the implant surface [ 73 , 74 , 75 , 76 , 77 , 78 ]. As the crystalline coating is much thicker than the amorphous coating, it is supposed to provide more calcium and phosphate to continuously sustain bone formation.…”

Section: Discussionmentioning

confidence: 99%

Crystalline Biomimetic Calcium Phosphate Coating on Mini-Pin Implants to Accelerate Osseointegration and Extend Drug Release Duration for an Orthodontic Application

Wang

et al. 2022

Nanomaterials

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Miniscrew implants (MSIs) have been widely used as temporary anchorage devices in orthodontic clinics. However, one of their major limitations is the relatively high failure rate. We hypothesize that a biomimetic calcium phosphate (BioCaP) coating layer on mini-pin implants might be able to accelerate the osseointegration, and can be a carrier for biological agents. A novel mini-pin implant to mimic the MSIs was used. BioCaP (amorphous or crystalline) coatings with or without the presence of bovine serum albumin (BSA) were applied on such implants and inserted in the metaphyseal tibia in rats. The percentage of bone to implant contact (BIC) in histomorphometric analysis was used to evaluate the osteoconductivity of such implants from six different groups (n=6 rats per group): (1) no coating no BSA group, (2) no coating BSA adsorption group, (3) amorphous BioCaP coating group, (4) amorphous BioCaP coating-incorporated BSA group, (5) crystalline BioCaP coating group, and (6) crystalline BioCaP coating-incorporated BSA group. Samples were retrieved 3 days, 1 week, 2 weeks, and 4 weeks post-surgery. The results showed that the crystalline BioCaP coating served as a drug carrier with a sustained release profile. Furthermore, the significant increase in BIC occurred at week 1 in the crystalline coating group, but at week 2 or week 4 in other groups. These findings indicate that the crystalline BioCaP coating can be a promising surface modification to facilitate early osseointegration and increase the success rate of miniscrew implants in orthodontic clinics.

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Section: Discussionmentioning

confidence: 99%

Crystalline Biomimetic Calcium Phosphate Coating on Mini-Pin Implants to Accelerate Osseointegration and Extend Drug Release Duration for an Orthodontic Application

Wang

et al. 2022

Nanomaterials

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“…Osteoblasts and osteoclasts have the potential to repair fracture trauma on their own. However, the repair of fractures can be prolonged in various underlying diseases, such as diabetes ( Chen et al, 2022b ), vascular diseases ( Liu et al, 2022 ), and autoimmune diseases ( Tian et al, 2022 ). These diseases often affect bone repair by altering blood vessel formation, including microvascular regeneration ( Zheng et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration

Yang

et al. 2022

PeerJ

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Objective Osteochondral decellularization can promote local vascular regeneration, but the exact mechanism is unknown. The aim of this study is to study osteogenic microvascular regeneration in single cells. Methods The scRNA-seq dataset of human periosteal-derived cells (hPDCs) were analyzed by pySCENIC. To examine the role of TBX3 in osteogenesis and vascularization, cell transfection, qRT-PCR, western blot, and CCK-8 cell proliferation assays were performed. Results TCF7L2, TBX3, FLI1, NFKB2, and EZH2 were found to be transcription factors (TFs) most closely associated with corresponding cells. The regulatory network of these TFs was then visualized. Our study knocked down the expression of TBX3 in human osteoblast cell lines. In the TBX3 knockdown group, we observed decreased expression of VEGFA, VEGFB, and VEGFC. Moreover, Western blot analysis showed that downregulating TBX3 resulted in a reduction of VEGFA expression. And TBX3 stimulated osteoblast proliferation in CCK-8 assays. Conclusion TBX3 regulates VEGFA expression and promotes osteoblast proliferation in skeletal microvasculature formation. The findings provide a theoretical basis for investigating the role of TBX3 in promoting local vascular regeneration.

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“…104 In terms of biological characteristics, Janus hydrogels can possess properties similar to that of biological tissues, offering improved biocompatibility and bioactivity. 105 For instance, researchers have manipulated the structure of Janus hydrogels to mimic the mechanical properties of different biological tissues or functionalize the surface of hydrogels to enhance their interaction with biomolecules. Prajatelistia et al devised a Janus-guided bone regeneration membrane comprising chitosan nanofibers and a poly(MPC-co-TSMA) (PMT) layer, which augmented the mechanical performance of newly formed bone on the defect side, suppressed the growth of fibroblast cells in soft tissue regions, and facilitated the development of the guided bone regeneration membrane (Fig.…”

Section: Janus Hydrogels Reinforcing Biomaterialsmentioning

confidence: 99%

Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies

Jiang,

Zhu,

et al. 2024

Biomater. Sci.

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Osteoinductive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia

Cited by 15 publications

References 42 publications

Crystalline Biomimetic Calcium Phosphate Coating on Mini-Pin Implants to Accelerate Osseointegration and Extend Drug Release Duration for an Orthodontic Application

Crystalline Biomimetic Calcium Phosphate Coating on Mini-Pin Implants to Accelerate Osseointegration and Extend Drug Release Duration for an Orthodontic Application

TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration

Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies

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