Osteoid osteoma: An evaluation of diagnostic modalities

Omojola, Matthew F.; Cockshott, W. Peter; Beatty, Erica

doi:10.1016/s0009-9260(81)80161-4

Cited by 26 publications

(1 citation statement)

References 12 publications

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“…SPECT skeletal scintigraphy clearly and conclusively localizes the nidus as a focal avid uptake in the middle of the lesion, with a decremental uptake toward the periphery. [67] Knowledge of the precise localization of the nidus guides the surgeon to decide on the best surgical approach with minimal intervention and at the same time achieve complete excision of the tumor. Case No.…”

Section: Discussionmentioning

confidence: 99%

Nidus localization in osteod osteoma by SPECT skeletal scintigraphy: Aid to diagnosis and surgical approach

et al. 2010

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Osteod osteoma, although not a common clinical occurrence, does pose problems both in diagnosis and surgical management. Initial plain radiographic diagnosis is sometimes fraught with the limitation of not being able to differentiate from chronic osteomyelitis and stress fracture. CT-aided localization of the nidus is also often inconclusive. Radionuclide single photon emission computed tomography (SPECT) scintigraphy is highly sensitive in localizing the active nidus and also orients the lesion in a three-dimensional plane well, for effective surgical removal

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Section: Discussionmentioning

confidence: 99%

Nidus localization in osteod osteoma by SPECT skeletal scintigraphy: Aid to diagnosis and surgical approach

et al. 2010

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APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

Miclea

Karperien

Langers

et al. 2010

Journal of Bone and Mineral Research

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The canonical Wnt pathway plays a key regulatory role in osteoblastogenesis and bone mass acquisition through its main effector, bcatenin. Adenomatous polyposis coli (APC) represents the key intracellular gatekeeper of b-catenin turnover, and heterozygous germline mutations in the APC gene cause familial adenomatous polyposis (FAP). Whether APC mutations affect bone mass has not been previously investigated. We conducted a cross-sectional study evaluating skeletal status in FAP patients with a documented APC mutation. Twenty-two FAP patients with a mean age of 42 years (54.5% women) were included in this study. Mean bone mineral density (BMD) Z-scores were significantly increased above normal at all measured sites: lumbar spine (p < .01), total hip (p < .01), femoral neck (p < .05), and trochanter (p < .01). Z-scores were þ1 or greater in 14 patients (63.6%) and þ2 or greater in 5 (22.7%). Mean values of bone turnover markers were within normal ranges. There was a significant positive correlation between procollagen type I N-terminal propeptide (P1NP) and b-crosslaps (b-CTX) (r ¼ 0.70, p < .001) and between these markers and sclerostin and BMD measurements. We demonstrate that FAP patients display a significantly higher than normal mean BMD compared with age-and sex-matched healthy controls in the presence of a balanced bone turnover. Our data suggest a state of ''controlled'' activation of the Wnt signaling pathway in heterozygous carriers of APC mutations, most likely owing to upregulation of cytoplasmic b-catenin levels. ß

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The Bone Scan in Paediatrics

Gordon¹,

Peters²

1987

Bone Scanning in Clinical Practice

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Osteoid osteoma: An evaluation of diagnostic modalities

Cited by 26 publications

References 12 publications

Nidus localization in osteod osteoma by SPECT skeletal scintigraphy: Aid to diagnosis and surgical approach

Nidus localization in osteod osteoma by SPECT skeletal scintigraphy: Aid to diagnosis and surgical approach

APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

The Bone Scan in Paediatrics

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