“…The typical clinical picture of the disease is pain that worsens at night, which may be alleviated by Non-Steroidal Anti Inflammatory Drugs (NSAIDs) [5] , [6] . OO is highly vascularized and innervated [7] , and the underlying cause of pain seems to be related to high prostaglandin levels (100–1000 × higher than normal), with prostaglandin E2 being the main subtype. In addition, these prostaglandins are responsible for vasodilatation and edema formation in the surrounding bone marrow and soft tissues [5] , [6] .…”