Osteoglycin as a Potential Biomarker of Mild Kidney Function Impairment in Type 2 Diabetes Patients

Abstract

Osteoglycin (OGN) could be a biomarker of mild kidney function impairment in type 2 diabetes (T2D). Our study aimed to determine the association between serum OGN and impaired kidney function risk in T2D patients and to analyze its potential role as an estimator of kidney disturbances in this population. This cross-sectional study included 147 T2D patients (65 ± 8 years, 58.5% males), and 75 healthy controls (63 ± 10 years, 36% males). Circulating OGN levels were determined by ELISA. Linear regression modeling was performed to determine the variables influencing circulating OGN, and an ROC curve was plotted to assess the usefulness of OGN as an estimator of diabetic kidney disease risk. Circulating OGN was significantly increased in T2D patients compared to controls (18.41 (14.45–23.27) ng/mL vs. 8.74 (7.03–12.35) ng/mL; p < 0.001). We found a progressive increase in serum OGN according to the severity of kidney impairment in T2D patients (normal kidney function: 16.14 (12.13–20.48) ng/mL; mildly impaired kidney function: 19.15 (15.78–25.90) ng/mL; moderate impaired kidney function: 21.80 (15.06–29.22) ng/mL; p = 0.006). Circulating OGN was an independent estimator of mildly impaired kidney function risk in T2D patients. We suggest that serum OGN could act as an albuminuria-independent biomarker of incipient kidney dysfunction in T2D patients.

Exploring the role of osteoglycin in type 2 diabetes: implications for insulin resistance and vascular pathophysiology

“…Some studies have reported higher osteoglycin levels in serum in T2D patients with nephropathy ( 43 ). Consistently, our previous study reported increased serum osteoglycin levels associated with mild kidney function impairment in patients with T2D compared with healthy subjects proposing osteoglycin as an early biomarker of kidney impairment ( 44 ). In agreement, our results have shown a negative correlation between circulating osteoglycin levels and eGFR in patients with T2D.…”

Osteoinductive factor as a significant marker for the diagnosis of early diabetic nephropathy

“…glucose, serum creatinine, blood urea, urine albumin / creatinine ratio, total cholesterol, TG and LDL, while there was negative correlation between OIF and both of eGFR and HDL in T2DM patients (Normoal buminuric, microalbuminuric and macroalbuminuric groups). These outcomes support the findings of Wang., et al, [7] who said that, there was an important positive relation between OIF and the same parameters as well, Tamer A., et al, [8] , & González., et al, [10] , showed that, there was a positive correlation between OIF and urinary albumin creatinine ratio, while there was a negative correlation between OIF and eGFR in diabetic patients. Tamer A., et al, [8] , reported that OIF and creatinine exhibited a positive association whereas eGFR and OIF had a negative association.…”

“…OIF has important functions in both lipid and glucose metabolism and is integrated into the typical vascular matrix. OIF has therefore been recently hypothesised to play an essential part in the glomerular disease related to nephropathy caused by diabetes, and it has also been investigated as an indicator for earlier DN [5] . The work's aim was to clarify the significance of OIF as a sensitive indicator for the detection of early diabetic nephropathy.…”

In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI

“…Moreover, T2D will affect 693 million people in 2045 ( 2 ). Uncontrolled T2D can lead to severe chronic conditions, including micro and macrovascular diseases ( 3 , 4 ). Thus, causing enormous pressure on healthcare systems.…”