Osteogenic silver oxide doped mesoporous bioactive glass for controlled release of doxorubicin against bone cancer cell line (MG-63): In vitro and in vivo cytotoxicity evaluation

Rahman, Muhammad Saif Ur; Tahir, Muhammad; Noreen, Saima; Yasir, Muhammad; Khan, Muhammad Bilal; Mahmood, Tahir; Bahadur, Ali; Shoaib, Muhammad

doi:10.1016/j.ceramint.2020.01.086

Cited by 42 publications

(23 citation statements)

References 35 publications

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“…75 The results demonstrated that these smart systems provided higher toxicity for cancer cells in vitro and showed a selective increase in tumor death in vivo. 15,[75][76][77][78][79][80][81][82][83][84][85][86] After entering the body, the drug goes through four stages, including absorption, release, F I G U R E 4 (A) Schematic of drug-loaded mesoporous bioactive glass (MBG) preparation. (B) The effect of MBGs on cancer cells and normal cells.…”

Section: Drug and Ion Deliverymentioning

confidence: 99%

“…Overall, 81% of IMT was released for 250 h at an acidic pH = 4.4, at 12.19 μg/ml of IMT-MBG, and significant inhibitory effects were observed on the viability of MG-63 osteosarcoma cancer cells. 74 It has been proven that hollow spheres of MBGs doped with different ions (Se, 77 Tb, 83 Ag, 84 Sm, 85 Ca 102,103 ) have a higher drug-loading capacity and more stable release than dopant-free BGs. Interaction between ions and drugs can synergistically enhance the anticancer effect and improve drug loading.…”

Section: Drug and Ion Deliverymentioning

confidence: 99%

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A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini

Chinijani

Khachatourian

et al. 2022

Int J of Appl Glass Sci

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There is an ongoing profound shift in using glass as a primarily passive material to one that instills active properties. We believe and demonstrate that bioactive glasses (BGs) and glass–ceramics (BGCs) as functional biomaterials for cancer therapy can transform the world of healthcare in the 21st century. Melt/gel‐derived BGs and BGCs can carry many exotic elements, including less common rare‐earth, and trigger highly efficient anticancer properties via the combination of radiotherapy, photothermal therapy, magnetic hyperthermia, along with drug or therapeutic ions delivery. The addition of these dopants modifies the bioactivity, imparts novel functionalities, and induces specific biological effects that are not achievable using other classes of biomaterials. In this paper, we have briefly reviewed and discussed the current knowledge on promising compositions, processing parameters, and applications of BGs and BGCs in treating cancer. We also envisage the need for further research on this particular, unique class of BGs and BGCs.

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Section: Drug and Ion Deliverymentioning

confidence: 99%

Section: Drug and Ion Deliverymentioning

confidence: 99%

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini

Chinijani

Khachatourian

et al. 2022

Int J of Appl Glass Sci

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“…[116] Moreover, drug loading concentrations affect the release profile of MBGs. [115,118] In addition to drug loading, ther-apeutic ions and trace elements also affect drug release profiles. Example (1); the addition of selenium (Se), europium (Eu), and terbium (Tb) to MBGs has been shown to decrease drug release kinetics.…”

Section: Chemotherapeutic Drug Deliverymentioning

confidence: 99%

“…A recent investigation developed silver oxide (Ag 2 O)-doped MBG nanoparticles for the controlled release of DOX and evaluated the anticancer activity in human bone tumor cells (MG-63). [118] It was proposed that Ag nanoparticles in combination with DOX could act as potential anticancer agents. Their cytotoxic mechanisms against tumor cells typically trigger oxidative stress, subsequent induction of mitochondrial damage, apoptosis, and DNA damage.…”

Section: Biomolecular Mechanisms Underlying Anticancer Effects Of Mbgsmentioning

confidence: 99%

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

et al. 2021

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Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy‐to‐functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli‐responsive nanoplatforms), and immunological profile of MBG‐based nanodevices in reference to the development of novel cancer therapeutics.

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“…These are usually synthesized by the evaporation-induced self-assembly (EISA) and sol-gel methods, which can obtain MBG with a uniform pore size and large surface area. In view of MBG's characterizations, it could be applied for the controlled releasing and stabilization of functional contents [15][16][17], as well as for enhancing bone formation by inducing hydroxyapatite (HA) crystallization on its surface [18][19][20]. In previous studies, silver-containing mesoporous bioactive glass (MBG-Ag) has been used as a biomaterial for combatting multidrug-resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial Effects of Matrix-Induced Silver Ions against Antibiotic-Resistant ESKAPE Pathogens

et al. 2021

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Recently, drug-resistant bacterial infections, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), have become a critical health issue worldwide, highlighting the emerging need for novel antibacterial agents. In this study, silver nanoparticles were extracted from silver-containing mesoporous bioactive glass (MBG-Ag) using four different matrixes, including water, phosphate buffer saline (PBS), tryptic soy broth (TSB), and taurine (Tau). The inductively coupled plasma-mass spectrometer (ICP-MS) results demonstrated that the silver concentration of Tau-Ag was the highest among the four matrixes. The Tau-Ag was also observed to have 87.35% silver ions in its X-ray photoelectron spectrometer (XPS) spectra. The micrograph of transmission electron microscope (TEM) displayed a uniform distribution of silver nanoparticles, which was confined in a smaller size compared to that in TSB-Ag. Moreover, the peak shifts observed in the Fourier-transform infrared spectrometer (FTIR) spectrum implied that the -SO32− and -NH groups in taurine may interact with silver. A low cytotoxicity was noted for Tau-Ag, with approximately 70% of cells surviving at 0.63 mg/mL. Compared to the other three matrix-induced silver agents, Tau-Ag represented a better antibacterial effect against methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) value of 0.63 mg/mL and a postponed growth of 0.31 mg/mL observed. Further antibacterial examinations illustrated the presence of remarkable antibacterial activities against vancomycin-resistant Enterococcus feacium, carbapenem-resistant Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii, and carbapenem-resistant Pseudomonas aeruginosa. Given our observations and multiple bioactive functions of taurine (prevent patients from inflammation and oxidative-stress injuries), we anticipate that taurine matrix-induced silver ions would be a biomedical material with a high potential for combatting drug-resistant ESKAPE pathogens.

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Osteogenic silver oxide doped mesoporous bioactive glass for controlled release of doxorubicin against bone cancer cell line (MG-63): In vitro and in vivo cytotoxicity evaluation

Cited by 42 publications

References 35 publications

A critical review of bioactive glasses and glass–ceramics in cancer therapy

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Evaluation of Antibacterial Effects of Matrix-Induced Silver Ions against Antibiotic-Resistant ESKAPE Pathogens

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