Osteogenic Sarcoma of the Prostate

Meeter, Urquhart L.; Richards, John N.

doi:10.1016/s0022-5347(17)65615-5

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…However, there is no increased risk of other malignancies after the therapy. The possibility of an osteogenic sarcoma induced by radiation therapy of the prostate is much less than that reported for other sites 2–4 . Previously, osteogenic sarcomas associated with estrogen stimulation have been reported 3,8 .…”

Section: Discussionmentioning

confidence: 90%

“…Neoplasms with sarcomatous differentiation occurring at irradiated sites are well known but have rarely been documented after the treatment of the prostate cancer 2 . Few reports of osteogenic sarcoma in such circumstances have been reported previously 2–4 . We report a case of osteogenic sarcoma occurring in the prostate after therapy for adenocarcinoma.…”

Section: Introductionmentioning

confidence: 82%

“…2 Few reports of osteogenic sarcoma in such circumstances have been reported previously. [2][3][4] We report a case of osteogenic sarcoma occurring in the prostate after therapy for adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic sarcoma of the prostate

Nishiyama¹,

Ikarashi²,

Terunuma³

et al. 2001

Int J of Urology

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A 76-year-old man was treated with bilateral orchiectomy, estramustine phosphate and pelvic irradiation for prostate cancer. Osteogenic sarcoma of the prostate developed 18 months after the treatment. Postmortem examination revealed that the tumor was 8 cm in diameter and had infiltrated into the bladder and rectal walls and had resulted in peritoneal dissemination. There was no distant metastasis. Macroscopically, the tumor was ashen, firm and relatively homogenous and diffusely spread. Histologically, it was composed of spindle and pleomorphic cells, which were making osteoid with calcification. There was no ordinary tubular formation as shown in adenocarcinoma of the prostate. No positive immunostaining for prostate-specific antigen, epithelial membrane antigen and cytokeratin (AE-1, AE-3) were confirmed. Positive immunostaining for nonepithelial marker vimentin was confirmed. The ultimate diagnosis was osteogenic sarcoma of the prostate.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 82%

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Osteogenic sarcoma of the prostate

Nishiyama¹,

Ikarashi²,

Terunuma³

et al. 2001

Int J of Urology

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“…In approximately 30% of cases, heterologous elements of osteosarcoma, chondrosarcoma, or rhabdomyosarcoma are also present, which may aid in the diagnosis. [4] Also, even in cases with heterologous elements, the spindle cell component often expresses keratin suggesting a common origin rather than a collision tumor composed of sarcoma and carcinoma. The utility of ancillary studies, including immunohistochemistry, is often limited and the main criteria for diagnosis are the morphological findings by routine H and E stain.…”

Section: Discussionmentioning

confidence: 99%

A rare case of prostatic malignancy

et al. 2012

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A 70-year-old male presented with refractory urinary retention 3 years back. He had undergone a prior trans urethral resection of prostate (TURP) 5 months back elsewhere. A revision TURP was done and the histopathology showed differentiated adenocarcinoma with cartilaginous and osseous metaplasia. Bone scan showed no evidence of metastasis. He underwent bilateral orchidectomy soon after. He presented with urinary retention 14 months later and underwent TURP. Hard prostatic tissue was resected and histopathology reports were same as previous report. Bone scan showed evidence of solitary metastasis in the second rib. MRI and CT scan showed re-growth. He had persisting lower urinary tract symptoms with hematuria. A palliative radiation was given which alleviated the urinary symptoms; patient refused radical cystoprostatectomy and currently is on conservative management.

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“…Primary prostatic osteosarcomas have been reported in the context of mixed histological subtypes, most often incorporating sarcomatous and adenomatous elements [1,2] , and almost uniformly occurring following pelvic or prostatic radiation or androgen deprivation therapy [3,4] . To our knowledge, this is the first reported case of a pure primary osteogenic sarcoma arising de novo in a non-irradiated prostate.…”

Section: Introductionmentioning

confidence: 99%

Pure Primary Prostatic Osteosarcoma Arising in a Non-Irradiated Prostate

Rabbani

Fine²,

D’Adamo³

et al. 2009

Urol Int

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A 68-year-old man who initially presented with hematuria was found on prostate biopsy to have sarcoma of the prostate with osteogenic features. Radiological examination revealed a locally advanced pelvic mass involving the prostate, seminal vesicles, and rectal wall without metastatic disease. The patient underwent total pelvic exenteration with intraoperative radiotherapy. The tumor was composed of two nodules measuring 7.5 and 4.5 cm involving the prostate, both seminal vesicles, the bladder, rectum, and perirectal fibroadipose tissue. The final diagnosis was osteogenic sarcoma of the prostate.

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Osteogenic Sarcoma of the Prostate

Cited by 11 publications

References 7 publications

Osteogenic sarcoma of the prostate

Osteogenic sarcoma of the prostate

A rare case of prostatic malignancy

Pure Primary Prostatic Osteosarcoma Arising in a Non-Irradiated Prostate

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