Osteogenic Sarcoma of the Head and Neck: The UCLA Experience

Mark, Rufus J.; Sercarz, Joel A.; Tran, Lisa; Dodd, Leslie G.; Selch, Michael T.; Calcaterra, Thomas C.

doi:10.1001/archotol.1991.01870190073015

Cited by 113 publications

(74 citation statements)

References 21 publications

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“…Patient age was not reported or analyzed with respect to survival differences. 35,38,45,53 Although the paucity of cases makes standardization of care difficult, it appears that when gross-total resection cannot be achieved, extensive resection coupled with adjuvant chemotherapy or radiation optimizes long-term survival. 15,63,64 Resection of involved dura is an important component of achieving maximal resection.…”

Section: Treatmentmentioning

confidence: 99%

“…Twenty-three cases were de novo cranial osteosarcomas: 14 calvarial tumors and 9 tumors of the skull base. 4,9,12,15,18,22,24,27,33,41,42,45,46,50,52,56,58,62,64,66 Nine cases of cranial osteosarcoma secondary to prior therapeutic radiation have been reported in children, 2 involving tumors of the skull base and 7 involving tumors of the calvaria. 8,15,16,33,39,54,55 Four cases of metastatic cranial osteosarcoma have been reported: 3 cases of metastatic cranial osteosarcoma from primary long bone tumors (2 involving the calvaria and 1 involving the cranial base) 40,42,44 and 1 case of metastatic osteosarcoma to the cranial base with a history of radiotherapy, in the context of multifocal disease.…”

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

“…4,12,15,41,45,46,50,62,64 Patients in some of the earlier cases were treated without resection or with resection with or without radiation. 9,24,42,56,66 When outcomes are reported, these patients had poor survival compared with more recent cases, suggesting that adjuvant chemotherapy and extensive resection improves outcome.…”

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

“…40,42 Nine cases of osteosarcoma of the skull base in pediatric patients have been reported. 12,18,22,45,46,50,52,64 Several papers describe unresectable tumors or subtotal resection of skull base osteosarcoma, due to the difficult anatomy. 12,38,45,46,64 Our third case is the first report describing an open transnasal approach to resection of osteosarcoma of the skull base in a pediatric patient.…”

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

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Osteosarcoma of the cranial vault and skull base in pediatric patients

Hadley

Gressot

Patel

et al. 2014

PED

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Cranial osteosarcoma is very rare in children, rendering the development of optimal treatment algorithms challenging. The authors present 3 cases of pediatric cranial osteosarcoma: a primary calvarial tumor, a cranial metastasis, and a primary osteosarcoma of the cranial base. A review of the literature demonstrates significant variation in the management of cranial osteosarcomas and the outcome for patients with these tumors. This series and literature review is presented to improve the understanding of pediatric cranial osteosarcoma and to reinforce the importance of maximal resection in optimizing outcome.

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Section: Treatmentmentioning

confidence: 99%

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

Section: Previously Reported Pediatric Cases Of Cranial Osteosarcomamentioning

confidence: 99%

See 2 more Smart Citations

Osteosarcoma of the cranial vault and skull base in pediatric patients

Hadley

Gressot

Patel

et al. 2014

PED

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“…2,3 In these sites, radiation therapy plays a m ore prom inent role as part of the de® nitive managem ent. 4 N eutron therapy, in particular, is asso ciated with an im proved chance for local control of unresectable tum ors com pared to sim ilar treatment using conventional photon radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Sarcoma of the Maxilla: Neutron Therapy for UnresectableDisease

Smoron

Lennox

McGee

1999

Sarcoma

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Pur pose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chem otherapy, which had reduced his pain, but had not measurably reduced the tumor. M ethods. The patient was treated with 66 M eV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days.Results. C T assessments indicate gradually increasing calci® cation and noticeable reduction of soft-tissue disease in the frontal sinus, orbit and maxillary antrum. There has been some recontouring of the facial structures. The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease. This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses.

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Resident's Page: Pathology

Askin¹,

Westra²

1994

Archives of Otolaryngology - Head and Neck Surgery

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Osteogenic Sarcoma of the Head and Neck: The UCLA Experience

Cited by 113 publications

References 21 publications

Osteosarcoma of the cranial vault and skull base in pediatric patients

Osteosarcoma of the cranial vault and skull base in pediatric patients

Osteogenic Sarcoma of the Maxilla: Neutron Therapy for UnresectableDisease

Resident's Page: Pathology

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