Osteogenic Potential of Porous Titanium. An Experimental Study in Sheep

Sirak, Sergey; Giesenhagen, Bernd; Kozhel, Ivan Vladimirovich; Schau, Ingmar; Shchetinin, Evgeny; Sletov, A.A.; Vukovic, Marco Alexander; Grimm, Wolf-Dieter

doi:10.1016/j.jnma.2018.11.003

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…Sheep are docile, easy to handle, and large enough for serial sampling and have hormone profiles, mineral metabolism, and bone structures similar to humans. [94,95] However, the higher cost is an obstacle for the application of sheep in researches. The in vivo tests of Sr-SLA in rabbits not only demonstrate mRNA expression upregulation of osteoblast genes and downregulation of osteoclast phenotype gene TRAP in the peri-implant bone, [96] but also higher removal torque value, which indicates the interfacial shear strength between the implant and bone tissue.…”

Section: Human Osteoblastsmentioning

confidence: 99%

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO 2 coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

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Section: Human Osteoblastsmentioning

confidence: 99%

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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“…ere is increasing demand for alloplastic graft materials in Implant Dentistry. Porous titanium granules (PTGs) are a biocompatible, nonresorbable alloplastic graft material with osteoconductive properties [2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Porous titanium granules have been studied in postextraction sockets [7,[15][16][17], maxillary sinus augmentation [4,6,[18][19][20][21], peri-implant defects [9,10,[22][23][24][25][26], supracrestal vertical bone augmentation [27], and periodontal defects [23,28]. ey have been studied in various animal models, such as rabbits [5,6,8,27], dogs [3,7,9,15,16], sheep [11], and mini-pigs [10,17,28], and humans as well [4, 13, 14, 18, 19, 21-26, 29, 30]. Among all animal models for medical and dental research, rabbits are widely used [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Porous Titanium Granules in comparison with Autogenous Bone Graft in Femoral Osseous Defects: A Histomorphometric Study of Bone Regeneration and Osseointegration in Rabbits

Pepelassi

Perrea

Dontas

et al. 2019

BioMed Research International

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Background. The high resorption rate of autogenous bone is a well-documented phenomenon that can lead to insufficient bone quality and quantity in an augmented area. Nonresorbable bone substitutes might perform better than autogenous bone in certain applications if they are able to provide adequate bone formation and graft osseointegration. Purpose. The aim of this study was to compare the osseous regeneration and graft integration in standardized defects in the rabbit femur treated either with porous titanium granules or autogenous osseous graft. Materials and Methods. Standardized femoral osseous defects were surgically induced in 45 New Zealand rabbits. Fifteen were treated with porous titanium granules (TIGRAN™-PTG) and membrane (PTGM), 15 with autogenous graft and membrane (AGM), and 15 with membrane alone (CM, control). At six weeks, the defects were assessed histologically and histomorphometrically. Results. PTGM as compared to AGM presented similar percentages of newly formed bone tissue, but a significantly higher fraction of the region of interest was filled with the bone substitute material. Accordingly, the composite of new bone plus bone substitute material showed significantly higher volumes for PTGM. Yet, the smaller amount of remaining autogenous bone was far better osseointegrated than the titanium granules, which in large regions showed no connection to newly formed bone. Both PTGM and AGM as compared to CM presented higher values of newly formed bone. Conclusions. This study demonstrated that PTG was similarly effective as autogenous osseous graft in achieving osseous regeneration while PTG performed markedly better in graft volume stability. The resulting higher total percentage of new bone combined with the bone substitute material in PTG could provide a superior foundation for implant placement.

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“…In addition to aesthetic and functional rehabilitation, the main function of implant dentistry is the prevention of peri-implant bone resorption as the main cause of peri-implant inflammation. The aim of this sheep study was to investigate the bony healing of zirconium dioxide implants with a special microrough surface using our currently developed lower jaw sheep model, see reviews [1,2]. As comparative samples were used titanium implants with acid-etched surfaces (OsteoActive ® ), which currently represent the "gold standard" in dental implantology.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of Zirconium Dioxide Implants With Microrough Surface Topography Compared to Titanium Implants - A Histological Study on Sheep

Grimm

2019

BJSTR

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Introduction: Dental implantology has established as an important treatment method in dental, oral and maxillofacial medicine. In addition to aesthetic and functional rehabilitation, the main function of implant dentistry is the prevention of peri-implant bone resorption as the main cause of peri-implant inflammation. The aim of this sheep study was to investigate the bony healing of zirconium dioxide implants with a special microrough surface using our currently developed lower jaw sheep model. Material and Methods:As comparative samples were used titanium implants with acid-etched surfaces (OsteoActive ® ), which currently represent the "gold standard" in dental implantology used are showing in Figure 1. The qualitative surface examinations of the investigated ceramic implants (Carident AG™, Switzerland) were performed with scanning electron microscope in high vacuum combined with an EDX detector for elemental analysis of the sample surface. For the animal experiment 6 clinically healthy sheep (Stavropol Sheep) were used. The bone-to-implant interface was investigated by qualitative histological analyses using REM analysis and the Technovit 9100 New (PMMA) embedding method. In addition, a TRAP analysis was performed to evaluate the cellular peri-implant bone regeneration process. Results:The histological evaluation of peri-implant bone formation was based on PMMA sections stained with toluidine Blu and polarization-optical images. Using TRAP staining we evaluate the quality of cellular bone formation. Direct bone attachment to the implant surfaces was observed both in areas with trabecular bone components and along zones consisting mainly of bone marrow. Physiological bone remodeling around the inserted implants was observed in both trial groups in cortical areas without differences. This is also confirmed by the REM examinations performed in parallel. Conclusion:These results support the conclusion that zirconium di-oxide implants have a comparable Osseo integrative capacity as titanium implants with acid-etched surfaces.

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Osteogenic Potential of Porous Titanium. An Experimental Study in Sheep

Cited by 8 publications

References 28 publications

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Porous Titanium Granules in comparison with Autogenous Bone Graft in Femoral Osseous Defects: A Histomorphometric Study of Bone Regeneration and Osseointegration in Rabbits

Osseointegration of Zirconium Dioxide Implants With Microrough Surface Topography Compared to Titanium Implants - A Histological Study on Sheep

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