Osteogenic Potential of Demineralized Dentin Matrix as Bone Graft Material

Hyo-Jung, Lee; Hong, Jisoo; Kim, Young-Kyun; Um, In-Woong; Lee, Jae‐Il

doi:10.2485/jhtb.26.223

Cited by 4 publications

(3 citation statements)

References 42 publications

(59 reference statements)

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“…Hyo et al evaluated the osteogenetic potential activity of a DDM (dentin demineralized matrix) in supporting the osteogenetic activity of MG-63 cells and compared it to a mixture of inorganic materials. Immunofluorescence assays showed that the fluorescence intensities of osteocalcin and osteonectin as biomarkers of cellular differentiation were higher on the DDM than a comparative specimen [18]. Non-significant differences in osteogenic activity between contaminated ADDM and the group after sterilization using EO gas were confirmed [19].…”

Section: Introductionmentioning

confidence: 82%

Stimulation of Osteogenic Activity of Autologous Teeth Hard Tissues as Bone Augmentation Material

Kučera,

Lofaj,

Nagyová-Krchova

et al. 2024

Biology

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The issue of bone volume loss is playing an increasing role in bone tissue engineering. Research has focused on studying the preparation and use of different types of human or xenogenic materials and their osteogenic properties. An alternative source for this purpose could be autologous extracted teeth. The simple preparation protocol, minimal immune response, and rapid organizing of the newly formed bone with optimal mechanical properties predispose autologous hard teeth tissues (HTTs) as a promising material suitable in the indication of augmentation of maxillary and mandible defects, comparable to other high-end augmentation materials. The aim of this study was to experimentally evaluate the osteogenic potential of ground native autologous HTTs prepared by different demineralization procedures, aimed at potentiating the osteoinductive and osteoconductive properties of their organic components. The results indicate that the most effective preparation process for HTT stimulation is the application of Cleanser for 10 min followed by exposure to 0.6 N HCl for 5 min with a wash in phosphate-buffered saline solution.

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Section: Introductionmentioning

confidence: 82%

Stimulation of Osteogenic Activity of Autologous Teeth Hard Tissues as Bone Augmentation Material

Kučera,

Lofaj,

Nagyová-Krchova

et al. 2024

Biology

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“…The surface analysis using SEM showed TDBS after the chemical treatment had less occlusion of the dentinal tubules leading to diffusion of more growth factors and exposure of collagen matrix 10,19,36) that might increase bone formation and resorption. This study also showed the resemblance of TDBS to Bio-Oss ® and OraGRAFT ® in terms of the density, roughness, and homogeneity.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical and osteogenic properties of chairside processed tooth derived bone substitute and bone graft materials

et al. 2021

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To analyze physicochemical such as surface structures, the crystallinity, chemical composition, calcium phosphate dissolution and osteogenic properties of tooth derived bone substitute (TDBS) processed chair-side and other grafting materials. The number of anaerobic and facultative anaerobic bacteria in the supernatant of processed TDBS was determined. Human osteoblasts were cocultured with TDBS or allograft in transwell system to examine cell migration. BMP2 released from TDBS was measured by ELISA. TDBS had high crystallinity similar to BoneCeramic while it had a broad pattern to ramus bone, OraGRAFT, and Bio-Oss. TDBS contained carbon, calcium, oxygen, phosphate, sodium and magnesium elements like others. Calcium/phosphorus dissolution of TDBS show closely related to those of mandibular ramus bone and OraGRAFT. In addition, microbial decontamination of TDBS by the chemical processing revealed a hundred percent efficacy. The osteoconductive and osteoinductive properties demonstrated in the TDBS processed chairside suggested the potential of an alternative for bone grafting material.

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“…We developed two types of DDM (AutoBT®): one is powder, the other is block. The clinical efficacy and safety of DDM powder and block have been approved as new health technology assessment (nHTA) in Korea 2015 based on the several experimental and clinical evidences [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Clinical Application of DDM/rhBMP-2 in Implant Dentistry

Um¹,

Kim²,

Yun³

et al. 2019

An Update of Dental Implantology and Biomaterial

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Recombinant human bone morphogenetic protein-2 (rhBMP-2) is well-known osteoinductive growth factors that can be used along with various carriers. Demineralized dentin matrix (DDM) that has osteoinductive and osteoconductive capacities was developed as potential candidate for rhBMP-2 carrier that has its endogenous growth factors and fulfils the requirements such as controlled release kinetics, biocompatibility, biodegradabilities and bone forming capacity. DDM loaded with rhBMP-2 (DDM/rhBMP-2) have been subjected to in vitro, in vivo studies for the purpose of proving the clinical safety and efficacy. Recently the clinical trials and outcomes of DDM/rhBMP-2 have also proved this composite to be safe and efficient in terms of enhanced bone formation, remodeling capacity and reduced concentration of rhBMP-2 in implant dentistry in Korea. This chapter will introduce the clinical application of DDM/rhBMP-2 in implant dentistry based on the related experimental and clinical researches.

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Osteogenic Potential of Demineralized Dentin Matrix as Bone Graft Material

Cited by 4 publications

References 42 publications

Stimulation of Osteogenic Activity of Autologous Teeth Hard Tissues as Bone Augmentation Material

Stimulation of Osteogenic Activity of Autologous Teeth Hard Tissues as Bone Augmentation Material

Physicochemical and osteogenic properties of chairside processed tooth derived bone substitute and bone graft materials

Clinical Application of DDM/rhBMP-2 in Implant Dentistry

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