Osteogenic organoid for bone regeneration: Healing of bone defect in congenital pseudoarthrosis of the tibia
Jose E Cardier,
Dylana Diaz-Solano,
Olga Wittig
et al.
Abstract:Background: Congenital pseudoarthrosis of the tibia (CPT) is an uncommon disease associated with failure to achieve bone union and recurrent fractures. There is evidence showing that CPT is associated with decreased osteogenesis. Based on the capacity of mesenchymal stromal cells (MSCs) to induce osteogenesis, we develop an osteogenic organoid (OstO) constituted by these cells, and other components of the bone niche, for inducing bone formation in a child diagnosed with CPT. Aim: To evaluate the capacity of an… Show more
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