Osteogenic capacity of collagen in repair of established periodontal defects

Ellender, Graham; Hammond, Richard; Papli, Rain; Mitrangas, Kathy; Bateman, John F.; Glattauer, Veronica; Thyer, James M.; Werkmeister, Jerome A.; Ramshaw, John A. M.

doi:10.1016/0267-6605(92)90101-x

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…The inflammatory reaction was significantly increased in two groups (polycarbonate barrier1b-TCP, polycaprolactone barrier1b-TCP) compared with the other groups (ePTFE barrier1b-TCP, silicone barrier1 b-TCP or control), questioning the biocompatibility of polycarbonate and polycaprolactone materials. The b-TCP particles were partially resorbed and Reason for exclusion Artzi et al (2003a) No periodontal defects (bony defects) Artzi et al (2003b) No periodontal defects (bony defects) Kohles et al (2000) No periodontal defects (bony defects) Moon et al (1996) No outcome measurements (descriptive histology) Ellender et al (1992) No outcome measurements (descriptive histology) Table 3. Data extraction from the included studies (n 5…”

Section: Effect Of the Combined Use Of Gtr And Bone Grafts On Furcatimentioning

confidence: 99%

Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Sculean

Nikolidakis

Schwarz

2008

J Clinic Periodontology

364

285

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Within its limits the present analysis indicates that: (a) The combination of barrier membranes and grafting materials may result in histological evidence of periodontal regeneration, predominantly bone repair. (b) No additional benefits of combination treatments were detected in models of three wall intrabony, Class II furcation or fenestration defects. (c) In supra-alveolar and two wall intrabony (missing buccal wall) defect models of periodontal regeneration, the additional use of a grafting material gave superior histological results of bone repair to barrier membranes alone. (d) In one study using a supra-alveolar model, combined graft and barrier membrane gave a superior result to graft alone.

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Section: Effect Of the Combined Use Of Gtr And Bone Grafts On Furcatimentioning

confidence: 99%

Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Sculean

Nikolidakis

Schwarz

2008

J Clinic Periodontology

364

285

View full text Add to dashboard Cite

show abstract

“…The disease pocket that forms can be cleaned, but the epithelium of the gingiva can migrate rapidly and reform a pocket and preventing repair. Insertion of a membrane can stop this cell migration and allow bony tissue regeneration and new attachment to form (76). Initial products for this indication were non-resorbable synthetic polymer membranes that were limited in performance (77).…”

Section: Vol 13 No 1 February 2001mentioning

confidence: 99%

“…Initial products for this indication were non-resorbable synthetic polymer membranes that were limited in performance (77). A plain collagen membrane was shown, however, to perform well in a dog model, allowing good bone re-growth over a 9-week period (76). Collagen membranes have the potential for further improvement through incorporation of biologically active agents such as antibiotics and growth factors.…”

Section: Vol 13 No 1 February 2001mentioning

confidence: 99%

Applications of Collagen in Medical Devices

Ramshaw

Vaughan

Werkmeister

2001

Biomed. Eng. Appl. Basis Commun.

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Collagen is the most abundant natural protein found in living systems. While there is a whole family of different collagen types, each differing in sequence, the properties that make this protein so attractive as the building blocks for medical devices, are reflected largely by the unique fibrillar structure of the molecule, as well as defined functional regions that interact with the surrounding cells and other matrix components. As a commercial medical product, collagen can be part of the natural tissue used in the device, or it can be fabricated as a reconstituted product from animal or recombinant sources. Both types of uses have distinct properties that convey advantages and disadvantages to the end product. This review examines the chemistry and biology of collagen and describes some well-documented examples of collagen-based medical devices produced in one or other of these formats.

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In vivo evaluation of a collagenous membrane as an absorbable adhesion barrier

Edwards

Glattauer

Nash³

et al. 1997

J. Biomed. Mater. Res.

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An absorbable membrane made from purified, pepsin-soluble collagen was compared to Interceed, an absorbable cellulose-based product, and to a control group for effectiveness in inhibiting the formation of adhesions between peritoneal surface injuries in adult rats. An adhesion scoring system was used to evaluate and compare the performance of the test materials with the control group in regard to the extent, tenacity, and type of any adhesions evident at 28 days following surgery. The collagen group performed significantly better (p < 0.05) than either the Interceed or control groups, showing fewer, less extensive adhesions. The collagen membranes resulted in either no or weak adhesions between the body wall and caecum. Adhesions in the Interceed group were quite variable and characterized by a marked peritoneal reaction in the caecal and body walls adjacent to adhesions. Control samples were characterized by close, dense fibrotic adhesions between the caecum and body wall. Both of the test materials showed some deficiencies in respect to their physical and handling properties that could be further improved for this indication.

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Osteogenic capacity of collagen in repair of established periodontal defects

Cited by 10 publications

References 11 publications

Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Applications of Collagen in Medical Devices

In vivo evaluation of a collagenous membrane as an absorbable adhesion barrier

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