Osteogenesis Promotion of Selenium-Doped Hydroxyapatite for Application as Bone Scaffold

Zakhireh, Solmaz; Adibkia, Khosro; Beygi‐Khosrowshahi, Younes; Barzegar-Jalali, Mohammad

doi:10.1007/s12011-020-02309-2

Cited by 19 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enhanced bone formation in vivo is also supported by the in vitro results that suggested higher osteogenesis of MSCs when grown on the Se-CaP coating. The osteogenic properties of Se have been reported by other groups, − which showed the increased expression of osteogenesis genes (e.g., alkaline phosphatase, osteocalcin, and collagen-I) and osteogenesis activity with Se treatment.…”

Section: Discussionsupporting

confidence: 65%

Layered Antimicrobial Selenium Nanoparticle–Calcium Phosphate Coating on 3D Printed Scaffolds Enhanced Bone Formation in Critical Size Defects

Vaquette

Bock

Tran

2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Preventing bacterial colonization on scaffolds while supporting tissue formation is highly desirable in tissue engineering as bacterial infection remains a clinically significant risk to any implanted biomaterials. Elemental selenium (Se0) nanoparticles have emerged as a promising antimicrobial biomaterial without tissue cell toxicity, yet it remains unknown if their biological properties are from soluble Se ions or from direct cell–nanoparticle interactions. To answer this question, in this study, we developed a layered coating consisting of a Se nanoparticle layer underneath a micrometer-thick, biomimetic calcium phosphate (CaP) layer. We showed, for the first time, that the release of soluble HSe– ions from the Se nanoparticles strongly inhibited planktonic growth and biofilm formation of key bacteria, Staphylococcus aureus. The Se-CaP coating was found to support higher bone formation than the CaP-only coating in critical-size calvarial defects in rats; this finding could be directly attributed to the released soluble Se ions as the CaP layers in both groups had no detectable differences in the porous morphology, chemistry, and release of Ca or P. The Se-CaP coating was highly versatile and applicable to various surface chemistries as it formed through simple precipitation from aqueous solutions at room temperature and therefore could be promising in bone regeneration scaffolds or orthopedic implant applications.

show abstract

Section: Discussionsupporting

confidence: 65%

Layered Antimicrobial Selenium Nanoparticle–Calcium Phosphate Coating on 3D Printed Scaffolds Enhanced Bone Formation in Critical Size Defects

Vaquette

Bock

Tran

2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…The effectiveness of BMP in bone repair has been demonstrated in clinical trials [ 107 , 108 ]. Lastly, there are also other supplements that may enhance the osteogeneic potential of ADSCs, and they include, but are not limited to, vitamin D3 [ 109 ], selenium [ 110 ], and alendronate [ 111 ].…”

Section: Type Of Msds Targetedmentioning

confidence: 99%

ADSC-Based Cell Therapies for Musculoskeletal Disorders: A Review of Recent Clinical Trials

Lee

Chae

Song

et al. 2021

IJMS

View full text Add to dashboard Cite

Recently published clinical trials involving the use of adipose-derived stem cells (ADSCs) indicated that approximately one-third of the studies were conducted on musculoskeletal disorders (MSD). MSD refers to a wide range of degenerative conditions of joints, bones, and muscles, and these conditions are the most common causes of chronic disability worldwide, being a major burden to the society. Conventional treatment modalities for MSD are not sufficient to correct the underlying structural abnormalities. Hence, ADSC-based cell therapies are being tested as a form of alternative, yet more effective, therapies in the management of MSDs. Therefore, in this review, MSDs subjected to the ADSC-based therapy were further categorized as arthritis, craniomaxillofacial defects, tendon/ligament related disorders, and spine disorders, and their brief characterization as well as the corresponding conventional therapeutic approaches with possible mechanisms with which ADSCs produce regenerative effects in disease-specific microenvironments were discussed to provide an overview of under which circumstances and on what bases the ADSC-based cell therapy was implemented. Providing an overview of the current status of ADSC-based cell therapy on MSDs can help to develop better and optimized strategies of ADSC-based therapeutics for MSDs as well as help to find novel clinical applications of ADSCs in the near future.

show abstract

“…Considering that the pH was maintained over 10 throughout the precipitation process of salt route, a possible explanation was that Cl ¹ substitution occurred at the position of OH ¹ . In addition, CO 3 2¹ contributed to the peaks around 1430 and 883 cm ¹1 , 26) indicating that a little amount of CO 2 from environment was absorbed, which is quite common in chemical co-precipitation method.…”

Section: Resultsmentioning

confidence: 99%

Modification of hydroxyapatite by doping lithium through acid-base reaction

Meng

Yokoi

Kang

et al. 2022

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

Lithium (Li) doping is increasingly regarded as an effective modification for hydroxyapatite (HA) due to its excellent performances in osteogenesis. However, traditional method involving calcium, lithium and phosphorus salt (salt route) usually brought some unexpected ions, which could influence the properties of the obtained materials largely. In the present study, acid-base reaction (acid-base route) was applied in a chemical coprecipitation method to achieve Li-doped HA in nano size (nLiHA) at various calcium to lithium ratios. Comparisons on structure and chemical composition between the nLiHA materials made from both routes (acidbase route and salt route) were subsequently conducted. As a result, synthesizing nLiHA through acid-base reaction was proved to be a feasible improvement on product purity and crystallinity.

show abstract

Osteogenesis Promotion of Selenium-Doped Hydroxyapatite for Application as Bone Scaffold

Cited by 19 publications

References 27 publications

Layered Antimicrobial Selenium Nanoparticle–Calcium Phosphate Coating on 3D Printed Scaffolds Enhanced Bone Formation in Critical Size Defects

Layered Antimicrobial Selenium Nanoparticle–Calcium Phosphate Coating on 3D Printed Scaffolds Enhanced Bone Formation in Critical Size Defects

ADSC-Based Cell Therapies for Musculoskeletal Disorders: A Review of Recent Clinical Trials

Modification of hydroxyapatite by doping lithium through acid-base reaction

Contact Info

Product

Resources

About