Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: Effect of pore architecture

Barba, Albert; Maazouz, Yassine; Díez-Escudero, Anna; Rappe, Katrin; Español, Montserrat; Montúfar, Edgar B.; Öhman‐Mägi, Caroline; Persson, Cecilia; Fontecha, P.; Manzanares-Céspedes, María Cristina; Franch, Jordi; Ginebra, Maria‐Pau

doi:10.1016/j.actbio.2018.09.003

Cited by 109 publications

(90 citation statements)

References 51 publications

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“…104 Pore structure is another important aspect of bone scaffolds. 7 The advantages of pores have been described in the numerous studies; they allow for osteoblasts migration and proliferation, the transport of nutrients and waste, 7,107,108 and vascularization. 109 Hence, well-interconnected pore structures could facilitate cell infiltration and the transportion of nutrient and nutritions and waste.…”

Section: From the Microscale Perspectivementioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage. However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering (TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

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Section: From the Microscale Perspectivementioning

confidence: 99%

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

2020

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“…In addition to ionic dopants, other parameters related to HAp particles and their 3D-printed scaffolds could be effective in directing cell fate (Ribeiro et al, 2010;Costa-Rodrigues et al, 2012;Li Q. et al, 2019) including pore architecture and surface topography of the scaffolds (orientation and roughness) (Roh et al, 2016(Roh et al, , 2017Barba et al, 2018). For example, it has been reported that the use of nanosized HAp particles in 3D-printed bone composite scaffolds (PCL/nanosized HAp particle) results in an enhanced adhesion, viability, and osteogenic differentiation of hMSCs when compared with the counterparts containing microsized HAp particles (Domingos et al, 2017).…”

Section: Potential and Significance In Hard Tissue Regeneration And Dmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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“…Previous studies on CDHA and nano‐HA, the main components of the PCaP scaffolds tested in this study, have convincingly shown their osteoconductive capacity. [ 14 ] Also, our work shows an osteoconductive component of the regenerative process, as neo‐bone is progressing through the scaffold from the host tissue, and integrates tightly with the ceramic remnants, but our analysis at a single time point provides no clear evidence for intrinsic osteoinduction. In other studies, osteoinductive properties in the absence of exogenously added growth factors have already been demonstrated, first for nano‐HA, [ 27 ] but also for CDHA, depending on the nanostructure of the biomimetic apatite particles resulting from the hardening process of the cement.…”

Section: Discussionmentioning

confidence: 85%

Orthotopic Bone Regeneration within 3D Printed Bioceramic Scaffolds with Region‐Dependent Porosity Gradients in an Equine Model

Diloksumpan

Bolaños

Cokelaere

et al. 2020

Adv Healthcare Materials

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The clinical translation of three-dimensionally printed bioceramic scaffolds with tailored architectures holds great promise toward the regeneration of bone to heal critical-size defects. Herein, the long-term in vivo performance of printed hydrogel-ceramic composites made of methacrylatedoligocaprolactone-poloxamer and low-temperature self-setting calciumphosphates is assessed in a large animal model. Scaffolds printed with different internal architectures, displaying either a designed porosity gradient or a constant pore distribution, are implanted in equine tuber coxae critical size defects. Bone ingrowth is challenged and facilitated only from one direction via encasing the bioceramic in a polycaprolactone shell. After 7 months, total new bone volume and scaffold degradation are significantly greater in structures with constant porosity. Interestingly, gradient scaffolds show lower extent of remodeling and regeneration even in areas having the same porosity as the constant scaffolds. Low regeneration in distal regions from the interface with native bone impairs ossification in proximal regions of the construct, suggesting that anisotropic architectures modulate the cross-talk between distant cells within critical-size defects. The study provides key information on how engineered architectural patterns impact osteoregeneration in vivo, and also indicates the equine tuber coxae as promising orthotopic model for studying materials stimulating bone formation.

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Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: Effect of pore architecture

Cited by 109 publications

References 51 publications

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Orthotopic Bone Regeneration within 3D Printed Bioceramic Scaffolds with Region‐Dependent Porosity Gradients in an Equine Model

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