Osteofibrous dysplasia (ossifying fibroma of long bones) a study of 12 cases

Abstract

A Study of 12 Cases YASUAKI NAKASHIMA. MD,' TAKA0 YAMAMURO, MD,t YUZO FUJIWARA, MD,* YOSHlHlKO KOTOURA, MD,t EIGO MORI, M D ,~ AND YOSHIHIRO HAMASHIMA, M D I I Osteofibrous dysplasia (ossifying fibroma of long bones) is one of the fibro-osseous lesions that affects the tibia and fibula in the first decade of life. A study of 12 patients with this lesion showed the high rate of recurrence after surgical intervention. Most commonly, the lesions are eccentrically located in the diaphysis of the tibia. Pseudarthrosis may develop in cases where the lesion is situated in the distal portion. Roentgenologic and histopathologic features are basically similar to those of monostotic fibrous d ysplasia of long bones. However, bony or osteoid trabeculae covered by osteoblasts enable distinction between osteofibrous dysplasia and monostotic fibrous dysplasia, as determined histologically. The current evidence indicates that surgery should not be attempted in patients under 10 years of age.

A clinicopathological and immunohistochemical study of osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma of long bones

“…Osteofibrous dysplasia or ossifying fibroma of the tibia and fibula is a distinct clinicopathological entity which is clearly separated from fibrous dysplasia of bones [2,3,11,18,21]. This lesion is unique in respect to its specific localization involving the cortex of the tibia and fibula.…”

“…OFD is a discrete clinicopathological entity characterized by a predilection for the tibia in children and an intracortical location with a histological appearance showing fibrous tissue, woven bone trabeculae with osteoblasts, and zonal architecture [2,3,18].…”

Atypical ossifying fibroma of forearm bones

“…[6][7][8] Involvement of other long bones is rare. [9][10][11] Ulna and radius involvement is reported in isolation. 5,12 Its aggressive behavior and recurrence have been noted in many studies.…”

Osteofibrous dysplasia of the tibia in a young adult treated by Sofield osteotomy

“…Osteofibrous dysplasia usually is confined to the cortex and is yellow to white in color, with a gritty, fibrous consistency. 8 Occasionally, hemorrhagic zones, cyst, focal of cartilaginous differentiation and multinucleated giant cells can be seen. 8,14 Osteofibrous dysplasia is characterized by two histological features:…”