Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice

Qin, Lei; Chen, Zecai; Yang, Dazhi; He, Tailin; Xu, Zhen; Zhang, Peijun; Chen, Di; Yi, Weihong; Xiao, Guozhi

doi:10.1016/j.jot.2023.05.001

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…For adipogenic differentiation, a commercial kit (MUXMX-90031, Cyagen) was purchased and differentiation assay was performed according to manufacturer's instructions. Oil Red O staining was performed to detect lipid accumulation of differentiated BMSCs as previously described [ 27 ]. And semi-quantification of adipocyte counts per area was performed through ImageJ Pro Plus 6.0.…”

Section: Materials and Methods ( See Table 1 )mentioning

confidence: 99%

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Li,

Zeng,

Shi

et al. 2024

Journal of Orthopaedic Translation

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Section: Materials and Methods ( See Table 1 )mentioning

confidence: 99%

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Li,

Zeng,

Shi

et al. 2024

Journal of Orthopaedic Translation

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“…93 Animal experiments showed that knocking down integrin β3 under mechanical stimulation could affect the FA signalling pathway in bone cells; as a result, the expression levels of phosphorylated focal adhesion kinase (p-FAK) and phosphorylated Talin 1 (p-Talin) proteins related to this pathway were reduced, reducing long bone formation. 94 Previous studies have suggested that oestrogen acts as a regulator to maintain bone metabolic balance, 95 and enhance the response of bone cells to mechanical stress. 96 suggest that osteoclastopenia caused by mechanical stimulation can also affect osteoclastogenesis through paracrine signals.…”

Section: Osteocytesmentioning

confidence: 99%

Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism

Yang,

Chen,

Yang

et al. 2024

J Cellular Molecular Medi

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Mechanical stress is an internal force between various parts of an object that resists external factors and effects that cause an object to deform, and mechanical stress is essential for various tissues that are constantly subjected to mechanical loads to function normally. Integrins are a class of transmembrane heterodimeric glycoprotein receptors that are important target proteins for the action of mechanical stress stimuli on cells and can convert extracellular physical and mechanical signals into intracellular bioelectrical signals, thereby regulating osteogenesis and osteolysis. Integrins play a bidirectional regulatory role in bone metabolism. In this paper, relevant literature published in recent years is reviewed and summarized. The characteristics of integrins and mechanical stress are introduced, as well as the mechanisms underlying responses of integrin to mechanical stress stimulation. The paper focuses on integrin‐mediated mechanical stress in different cells involved in bone metabolism and its associated signalling mechanisms. The purpose of this review is to provide a theoretical basis for the application of integrin‐mediated mechanical stress to the field of bone tissue repair and regeneration.

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“…Osteocytes, like osteoblasts and osteoclasts, contain both Beta1 and Beta3 integrins [142][143][144][145][146]. Beta1 integrins are paired with alpha2, alpha3, alpha4, and alpha5, while beta3 integrin is mostly paired with alphaV.…”

Section: Osteocytesmentioning

confidence: 99%

“…Beta1 integrins are paired with alpha2, alpha3, alpha4, and alpha5, while beta3 integrin is mostly paired with alphaV. Recent results have shown that the knockout of integrin beta3 in osteocytes resulted in reduced bone formation [143]. Knockout of beta 1 integrin in osteocytes also reduced bone formation and impaired mechanotransduction [145].…”

Section: Osteocytesmentioning

confidence: 99%

Receptors Implicated in Microgravity-Induced Bone Loss

Martinez,

Pelegrine,

Holliday

2024

Receptors

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For humans to explore and colonize the universe, both engineering and physiological obstacles must be successfully addressed. A major physiological problem is that humans lose bone rapidly in microgravity. Understanding the underlying mechanisms for this bone loss is crucial for designing strategies to ameliorate these effects. Because bone physiology is entangled with other organ systems, and bone loss is a component of human adaptation to microgravity, strategies to reduce bone loss must also account for potential effects on other systems. Here, we consider the receptors involved in normal bone remodeling and how this regulation is altered in low-gravity environments. We examine how single cells, tissues and organs, and humans as a whole are affected by low gravity, and the role of receptors that have been implicated in responses leading to bone loss. These include receptors linking cells to the extracellular matrix and to each other, alterations in the extracellular matrix associated with changes in gravity, and changes in fluid distribution and fluid behavior due to lack of gravity that may have effects on receptor-based signaling shared by bone and other regulatory systems. Inflammatory responses associated with the environment in space, which include microgravity and radiation, can also potentially trigger bone loss.

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Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice

Cited by 6 publications

References 36 publications

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism

Receptors Implicated in Microgravity-Induced Bone Loss

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