Osteoclasts and tumor cells dual targeting nanoparticle to treat bone metastases of lung cancer

Bai, Shao-bo; Liu, Daozhou; Cheng, Ying; Han, Chunchun; Liu, Miao; Cui, Minxuan; Zhang, Bang-Le; Mei, Qibing; Zhou, Siyuan

doi:10.1016/j.nano.2019.102054

Cited by 22 publications

(14 citation statements)

References 60 publications

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“…To neutralize the positive charge, we dissolved PAMAM in DMSO and added succinic anhydride (dihydro-2,5-diketotetrahydrofuran) to neutralize the PAMAM amino group. The amino group in PAMAM reacts with succinic anhydride to form amide bonds [6][7][8][9][10]. After the reaction, the product was dialyzed, lyophilized, weighed, and redissolved, the production is nearly neutral and we named the product "N-PAMAM," which is able to conjugate with goat anti-rabbit IgG.…”

Section: Resultsmentioning

confidence: 99%

A Group of Complexes Based on PAMAM and Quantum Dots Used in Clinical Immunoassays

et al. 2020

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We report a group of complexes used in clinical immunoassays. The complexes include a PAMAM-conjugated goat anti-rabbit IgG and a QDs-conjugated goat anti-mouse IgG. When rabbit anti-antigen and mouse anti-antigen are added, the corresponding antigen will be detected. The experiment, using the complexes, is simple, convenient, short in time, and short in steps. It is also applicable to different experiment methods, like to be used with FCM (flow cytometry), ICC (immunocytochemistry), and IHC (immunohistochemistry) to detect many kinds of antigens.

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Section: Resultsmentioning

confidence: 99%

A Group of Complexes Based on PAMAM and Quantum Dots Used in Clinical Immunoassays

et al. 2020

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“…Furthermore, the bone mineral density (BMD) is an important index for bone resorption. The BMD of the right hind limb of tumor-bearing nude mice was 2154 mg/cc, which is significantly higher than that of normal saline-treated, ALN-treated and DTX-treated tumor-bearing 8 nude mice [20]. This indicated that DTX@ALN-PAMAM could inhibit the bone resorption at bone metastases sites in tumor-bearing mice.…”

Section: In Vivo Anti-tumor Activity Of Dtx@aln-pamammentioning

confidence: 87%

Bone-targeted PAMAM micelle to treat bone metastases of lung cancer

Bai

Cheng

Liu

et al. 2019

Preprint

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Background: Bone is a frequent site of metastasis in lung cancer patients. So far, the treatment in bone metastasis of lung cancer still has not achieved any satisfactory effects in clinic. In this paper, alendronate (ALN) was selected to be connected with PAMAM via pH sensitive cis-aconitine anhydride (CA) to prepare bone-targeted micelle (DTX@ALN-PAMAM) to treat bone metastasis of lung cancer. Results: It was discovered that DTX@ALN-PAMAM released docetaxel (DTX) and ALN in pH-dependent manner. Besides, DTX@ALN-PAMAM showed high bind affinity with bone matrix, and quickly desorbed from bone matrix in weak acidic medium due to the rupture of cis-aconitamide bond between ALN and PAMAM. The in vitro results showed that DTX@ALN-PAMAM significantly enhanced the antitumor activity of DTX and decreased bone resorption through inhibiting the formation of osteoclasts in in-vitro 3D bone metastases model of lung cancer. In addition, DTX@ALN-PAMAM accumulated at bone metastases tissues for a relatively long time in tumor-bearing nude mice, which significantly reduced the bone resorption, relieved the pain response of tumor-bearing nude mice, and delayed the growth of bone metastases. Eventually, the therapeutic effect of DTX was improved on bone metastases of lung cancer. Conclusion: ALN modified PAMAM is a new and an effective platform for the treatment of bone metastasis of lung cancer.

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“…It is overexpressed in tumor cells and plays an important role in tumor metastasis and invasion. Hyaluronic acid, as a specific ligand for CD44 receptor, was used in many targeted delivery systems (Dosio et al, 2016;Bai et al, 2019). Kaili Wang et al fabricated CD44 and bone dual-targeted nano micelles via a series of esterification reactions, with oligosaccharides of hyaluronan targeting CD44 and ALN targeting bone.…”

Section: Dual Target Deliverymentioning

confidence: 99%

Section: Drug Distribution Optimizationmentioning

confidence: 99%

“…Stimulus-responsive drug delivery systems based on nanocarriers can be triggered by pH, enzymatic catalysis, magnetic, thermal, ultrasonic, electric, and irradiation stimuli (Liu, Yang, et al., 2016 ; Saravanakumar et al., 2017 ; Jain et al., 2018 ). Smart delivery systems for treating osteolysis can be activated by the osteolytic microenvironment such as low pH, high concentration of calcium, and active redox reaction to release drugs responsively (Karimi et al., 2016 ; Tan et al., 2016 ; Bai et al., 2019 ). Designed pH-sensitive delivery systems release drugs through protonation or deprotonation of groups (carboxylic acid group, amino group) or break of chemical bonds (hydrazone, acetal, cis-Aconityl, β-thiopropionate, etc.)…”

Section: Drug Release Optimizationmentioning

confidence: 99%

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The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials

Cheng

Wei

et al. 2020

Drug Delivery

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Osteoclasts and tumor cells dual targeting nanoparticle to treat bone metastases of lung cancer

Cited by 22 publications

References 60 publications

A Group of Complexes Based on PAMAM and Quantum Dots Used in Clinical Immunoassays

A Group of Complexes Based on PAMAM and Quantum Dots Used in Clinical Immunoassays

Bone-targeted PAMAM micelle to treat bone metastases of lung cancer

The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials

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