Osteoclastoma-like giant cell tumor of the thyroid.Report of a case with prolonged survival following partial excision and radiotherapy

Silverberg, Steven G.; Degiorgi, Lucio S.

doi:10.1002/1097-0142(197303)31:3<621::aid-cncr2820310319>3.0.co;2-n

Cited by 66 publications

(17 citation statements)

References 12 publications

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“…Occurrence of the tumors with the same histology is also known in visceral organs, such as the liver, gall bladder, pancreas, salivary gland, thyroid, skin, heart, lung, breast, intestine, larynx, and female genital tract, where they have been termed 'osteoclastoma-like giant-cell tumor' or 'giant-cell tumor.' [1][2][3][4][5][6][7][8][9] To the best of our knowledge, less than 20 case reports (maximum two cases per report) of osteoclast-like giant-cell tumor of the urothelial tract have been published in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Our study is the largest series in the literature of osteoclast-like giant-cell tumors arising in the urinary tract, and includes six patients.…”

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confidence: 99%

Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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Osteoclast-like giant-cell neoplasms of the urinary tract are rare. They are composed of ovoid or spindle-shaped mononuclear cells with evenly spaced osteoclast-like giant cells. Terminology, histogenesis, and biologic behavior of these tumors remain controversial. Six cases of osteoclast-like giant-cell neoplasms of the urinary tract were identified from the consultation files of two of the authors. Patients were all male and elderly (range 65-82), with the exception of one 39-year-old male. In all, 3/6 tumors developed in the bladder and 3/6 in the renal pelvis. Size ranged from 5 to 11 cm. One bladder and three renal pelvis tumors were high stage (pT3) at time of presentation. Adjacent to the osteoclast-like giant-cell neoplasm in the same specimen, all patients had urothelial carcinoma in situ and/or high-grade papillary urothelial carcinoma. Multinucleated cells had identical morphological and immunohistochemical properties of osteoclasts; positive for CD-68, LCA, CD51 and CD54, and negative for cytokeratins and EMA. Varying percentages of mononuclear cells expressed a-smooth muscle actin (4/6), desmin (1/6), S-100 (4/6), LCA (2/6) and CD68 (6/6). However, mononuclear cells were also positive for epithelial markers in 4/6 tumors (cytokeratins AE-1/AE-3, Cam 5.2, CK7 and/or EMA). p53 stained mononuclear tumor cells in three cases, paralleling the staining on the accompanying urothelial carcinoma. Ki-67 stained mononuclear tumor cells, but not osteoclast-like giant cells. Follow-up data were available in five cases. One patient developed recurrence of noninvasive urothelial carcinoma and is still alive. Four patients were dead due to disease within 15 months, three with distant metastases. The intimate association of these tumors with urothelial carcinoma along with their immunohistochemical profile supports an epithelial origin for the mononuclear cells and non-neoplastic reactive histiocytic lineage for the osteoclast-like giant cells.

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confidence: 99%

Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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“…Although the neoplasm had a predominantly giant cell pattern, there were also areas of spindled (Figure 2(c)) and epidermoid (Figure 2(d)) histology. These were not osteoclast-like giant cells as seen in a previously reported case of ATC with long survival of the patient [1]. Focally admixed with the undifferentiated tumor was also a well-differentiated oncocytic component (Figure 2(e)), which was localized centrally in the middle of the tumor, accounting for about 10% of the entire tumor.…”

Section: Case Reportmentioning

confidence: 55%

A Large Nonmetastatic Anaplastic Thyroid Cancer with Complete Thyroidal Confinement

Xing

Bishop

Mathioudakis

et al. 2011

Case Reports in Medicine

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Anaplastic thyroid cancer (ATC) is rare but extremely aggressive, which accounts for about 2% of all thyroid cancers yet nearly 50% of thyroid-cancer-associated deaths in the United States. The median survival time from diagnosis is 5 months, with a 1-year survival rate of only 20%. We report here a case of ATC in a 56-year-old man who survived a large ATC. Preoperative fine-needle aspiration biopsy study to a large right thyroid mass suggested ATC. Total thyroidectomy with radical lateral neck and central neck dissection removed a well-circumscribed 9.5 cm tumor without extrathyroidal extension or lymphovascular invasion. All 73 lymph nodes removed were negative for metastasis. The tumor consisted of highly pleomorphic, undifferentiated cells with large zones of necrosis and loss of thyroid transcription factor-1 and thyroglobulin expression. A focal well-differentiated component and PAX8 expression confirmed its thyroid follicular cell origin. Nine months after postsurgical adjuvant concurrent radiation therapy and chemotherapy, the patient remained well without clinical, biochemical, and radiographical evidence for cancer recurrence. This is an unusual case of ATC in that it is one of the largest ATC tumors reported to display mild pathologic behavior and relatively long-term patient survival.

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“…While usually benign, GCT is locally aggressive and most commonly occurs in the epiphysis of long bones. GCT of soft parts are very rare, but have been described [25,26], as have GCT of the thyroid [27] and pancreas [28,29]. …”

Section: Resultsmentioning

confidence: 99%