1998
DOI: 10.1006/bbrc.1998.9294
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Osteoclastogenesis Inhibitory Factor Suppresses Osteoclast Survival by Interfering in the Interaction of Stromal Cells with Osteoclast

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Cited by 114 publications
(94 citation statements)
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“…These results suggest that OPG affects the later unknown stage of osteoclast differentiation. In this regards, Akatsu et al (1998) reported that OPG inhibited the survival of osteoclasts formed in mouse marrow cultures in a dose-and timedependent manner, and suggested that OPG affected the osteoclast number by promoting apoptosis. also reported that apoptosis of osteoclasts was mediated by up-regulation of OPG, and that this phenomenon was induced by TGF-␤1.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These results suggest that OPG affects the later unknown stage of osteoclast differentiation. In this regards, Akatsu et al (1998) reported that OPG inhibited the survival of osteoclasts formed in mouse marrow cultures in a dose-and timedependent manner, and suggested that OPG affected the osteoclast number by promoting apoptosis. also reported that apoptosis of osteoclasts was mediated by up-regulation of OPG, and that this phenomenon was induced by TGF-␤1.…”
Section: Discussionmentioning
confidence: 99%
“…OPG appears to locally and/or systemically inhibit the differentiation of osteoclast precursors into mature osteoclasts, by interrupting the osteoblast-osteoclast precursor interaction (Simonet et al, 1997;Akatsu et al, 1998;Yasuda et al, 1998a, b). OPG also inhibits in vitro osteoclastogenesis elicited through distinct signaling pathways stimulated by 1,25(OH)2D3, PTH, or IL-11 (Simonet et al, 1997;Tsuda et al, 1997;Matsuzaki et al, 1998;Yasuda et al, 1998a).…”
mentioning
confidence: 99%
“…Akatsu et al (1998) reported that OPG inhibited the survival of OCs formed in mouse marrow cultures in a doseand time-dependent manner, and suggested that OPG reduced the number of OCs by promoting apoptosis. Murakami et al (1998) also reported that apoptosis of OCs was mediated by up-regulation of OPG.…”
Section: Discussionmentioning
confidence: 99%
“…Osteoprotegerin (OPG) is a novel secreted member of the tumor necrosis factor (TNF) receptor superfamily that negatively regulates osteoclastogenesis (Simonet et al, 1997;Tsuda et al, 1997;Buccay et al, 1998;Mizuno et al, 1998;Yasuda et al, 1998a, b;Bateman et al, 2000). OPG inhibits, locally or systemically, the differentiation of OC precursors into mature OCs by interrupting osteoblast-OC precursor interaction and decreases ovariectomy-induced bone loss in rats (Simonet et al, 1997; Akatsu et al, 1998;Yasuda et al, 1998a, b). OPG also inhibits in vitro osteoclastogenesis elicited through distinct signaling pathways stimulated by 1,25(OH) 2 D 3 , parathyroid hormone (PTH), or interleukin (IL)-11 (Simonet et al, 1997;Tsuda et al, 1997;Matsuzaki et al, 1998;Yasuda et al, 1998a).…”
mentioning
confidence: 99%
“…In vitro, OPG inhibits osteoclastogenesis, (9,14) blocks bone resorption by mature osteoclasts, (15,16) and promotes apoptosis of osteoclasts. (17)(18)(19) In vivo, treatment of tumor-bearing mice with OPG, given either at the onset of hypercalcemia or after it had occurred, resulted in a dose-dependent inhibition of tumor-induced increases in bone resorption and hypercalcemia and rapidly normalized blood ionized calcium. (20) Previously, we reported that the appearance of anti-gp46-197 Ab, an antibody recognizing the Asp197 to region, was synchronized with the deterioration of ATL, (21) and proposed that the antibody possibly cross-reacted with human cellular component(s) and that the interaction might be associated with the pathogenesis.…”
mentioning
confidence: 99%