Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

Alemán-Meza, Lucía; Gómez‐Macías, Gabriela Sofía; Barboza-Quintana, Oralia; Garza‐Guajardo, Raquel; Loya-Solis, Abelardo

doi:10.1155/2014/415328

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Carcinomas with reactive MGC have been reported in many other organs, such as the pancreas, breast and skin 6–11 . Only five cases of uterine cervical SCC with reactive MGC have been reported so far, 4,12–14 and this was the sixth such case (Table 1).…”

Section: Discussionmentioning

confidence: 89%

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Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Dejima

Hashimoto

Sasajima

et al. 2020

J of Obstet and Gynaecol

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Uterine cervical squamous cell carcinoma (SCC) with reactive multinucleated giant cells (MGC) is extremely rare. Here we present the case of a 49-year-old woman treated with radical hysterectomy, bilateral adnexectomy and lymph node dissection. Histologically, the cervical tumor was diagnosed as nonkeratinizing SCC of pT1b1N0M0, with negative surgical margin. Many MGC including osteoclast-like giant cells with immunohistochemical expression of cluster of differentiation 204, a marker for the M2 macrophage, were present around the tumor nests. The patient received postoperative radiation therapy and achieved 22 months of disease-free survival after the surgery. M2 macrophages promote aggressiveness of the carcinoma and it is suggested that SCC of the cervix with reactive MGC might have poor prognosis; however, our case paradoxically showed a favorable course. From literature review of six cases, including our case, the effect of MGC-reaction may vary with respect to other factors, such as age, cancer stage or histological type.

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Section: Discussionmentioning

confidence: 89%

“… 4 Our patient was a 49‐year‐old post‐menopausal woman, who was relatively younger patients in previously reported cases. Another patient below 50 years of age is also a disease‐free survivor 14 . Tumor immunity may be influenced by age.…”

Section: Discussionmentioning

confidence: 99%

Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Dejima

Hashimoto

Sasajima

et al. 2020

J of Obstet and Gynaecol

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“…On immunohistochemistry, CK and P63 were strongly positive in the squamous component and negative in osteoclastic giant cells. 12,23 David Thomas et al investigated the potential therapeutic effect of Denosumab, a fully human monoclonal antibody against RANKL, on tumor-cell survival and growth in patients with GCT. Thirty-seven patients with recurrent or unresectable GCT were enrolled and received subcutaneous Denosumab 120 mg monthly (every 28 days), with loading doses on days 8 and 15 of month 1.…”

Section: Malignant Giant Cell Tumor Of the Uterusmentioning

confidence: 99%

Malignant giant cell tumor of the uterus: a case report

Oliveira¹,

Stecca²,

Silva³

et al. 2021

BJOncology

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This report describes a rare case of malignant extraosseous giant cell tumor (GCT). It refers to a patient with an initial diagnosis of a locally advanced malignant GCT of the uterus, with disease progression to lung and mediastinum seven months after the diagnosis, requiring first line treatment with chemotherapy. Extraosseous presentation of GCT with early distant dissemination is unusual and the role of systemic cytotoxic treatment remains unclear.

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“…Despite their rarity, these unique cells have captured attention due to their potential diagnostic significance and implications for tumor biology. To the best of our knowledge, only six cases of SCCs with OGCs in the uterine cervix have been reported to date (4)(5)(6)(7)(8). This limited incidence underscores the importance of meticulous observation and thorough histopathological examination to identify and characterize such atypical tumor features within the cervix.…”

Section: Introductionmentioning

confidence: 98%

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

Castillo,

Perelló‑Fabregat,

García‑Gómez

et al. 2024

Mol Clin Oncol

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Squamous cell carcinoma (SCC) is a common tumor of the uterine cervix, usually related to human papillomavirus (HPV). While osteoclast-like giant cells (OGCs) have been reported to be associated with tumors at various locations, to the best of our knowledge, only six cases have been reported in the cervix to date. The present study describes the case of a 38-year-old woman with a medical history of ectopic pregnancy and vaginal childbirth, who presented with coitorrhagia. On physical examination, a mass of ~4 cm was found in the uterine cervix. A biopsy of this lesion revealed infiltrating SCC, leading to a radical hysterectomy 2 months later. The surgical specimen displayed an exophytic lesion with a maximum diameter of 3.5 cm confined to the uterine cervix, histologically consistent with an infiltrating non-keratinizing SCC. There was a prominent intra- and peritumoral chronic inflammatory reaction, and a high number of OGCs. Immunohistochemically, tumoral cells were positive for cytokeratin βE12, epithelial membrane antigen, p40, p63 and p16, and negative for CD68, vimentin and CD163. OGCs exhibited an inverted expression pattern, with positivity only for histiocytic markers. PCR for HPV detection revealed a HPV 34 genotype (probable high oncogenic risk). This profile suggests the non-neoplastic nature of OGCs, i.e. they should be considered as part of the immune response to the tumor. To the best of our knowledge, this case is the seventh instance of SCC with OGCs in the uterine cervix. Similar findings in other organs, such as the breast, pancreas or stomach, have been associated with a favorable prognosis. While two of the three reported cases with poor outcomes in the uterine cervix had an associated sarcomatoid component, the limited number of cases described to date in this location does not yet allow for an accurate prediction of behavior.

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Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

Cited by 4 publications

References 10 publications

Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Malignant giant cell tumor of the uterus: a case report

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

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